1.

論文(リポジトリ)

論文(リポジトリ)
Nakasone, Hiroki ; Sgkuawa, Hiroshi ; Nakayoshi, Tmofumi ; Kawakami, Yuko ; Kinjo, Fukunori ; Saito, Atushi ; Yamashiro, Akiko ; Nakayoshi, Tmokuni ; Ikema, Minoru ; Hirayama, Yoshikatsu
出版情報: 琉球医学会誌 = Ryukyu Medical Journal.  16  pp.117-121,  1996.  琉球医学会 — Ryukyu Medical Association
URL: http://hdl.handle.net/20.500.12000/0002016002
概要: The present study examined the efficacy and the predicting factors of response to interferon (IFN) alpha in patients wit h liver cirrhosis associated with hepatitis type C virus infection (LC type C). Sixty-seven patients were treated with IFN alpha and were classified into 2 Groups. Group 1 : Patients with liver cirrhosis, showing histological liver cirrhosis or chronic active hepatitis with lobular disorganization. Group 2 : Patients with chronic hepatitis, showing histological chronic persistent hepatitis or chronic active hepatitis without lobular disorganization. Sustained response to IFN was obtained in 5/17 (29.4%) and 24/50 (48%) of patients in Group 1 and Group 2, respectively. However, the difference was not significant. All patients in Group 2 showed a significant decrease in alanine aminotransferase (ALT) levels during the treatment, whereas 5 of the 17 patients in Group 1 showed no response. All sustained responders in Group 1 who were tested for serum HCV-RNA titer showed low serum HCV-RNA titer, which was less than 10^7 copies/ml, while all except one patient of the non-responders of Group 1 showed above 10^8 copies/ml. It is said that patients with LC type C are more resistant to IFN treatment compared to those with chronic hepatitis type C. However, our findings suggest that even in patients with LC type C, low serum HCV-RNA levels might be associated with better response to IFN.
論文
続きを見る
2.

論文(リポジトリ)

論文(リポジトリ)
Sakugawa, Hiroshi ; Nakasone, Hiroki ; Kawakami, Yuko ; Nakayoshi, Tomofumi ; Kinjo, Fukunori ; Saito, Atsushi ; Ikema, Minoru ; Yamashiro, Akihiro ; Nakayoshi, Tomokuni
出版情報: 琉球医学会誌 = Ryukyu Medical Journal.  15  pp.133-137,  1995.  琉球医学会 — Ryukyu Medical Association
URL: http://hdl.handle.net/20.500.12000/0002015946
概要: To compare the clinical utility of type IV collagen 7S domain and hyaluronate, as markers in the evaluation of liver fib rosis, 184 patients with biopsy-proven chronic viral liver disease (32; type B, 152; type C) were involved in this study. The two markers correlated well with the grade of liver fibrosis. The correlation coefficients of 7S-collagen and hyaluronate with the extent of fibrosis were 0.747 and 0.813, respectively. Very high values were seen more frequently in hyaluronate than in 7S-collagen, particularly in patients with moderate and severe fibrosis. Both markers also correlated strongly with conventional liver function tests except for alanine aminotransferase. In conclusion, serum hyaluronate was a more sensitive marker and seemed to more strongly correlate with the degree of hepatic fibrosis than type IV collagen 7S domain.
論文
続きを見る