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Kaneshima, Hiroshi ; Miyazato, Akiko ; Oshiro, Hajime ; Toyoda, Kazumasa ; Miyaguni, Takahiko ; Kakazu, Tomokazu ; Saito, Atushi ; Shiroma, Yoshiyuki
出版情報: 琉球医学会誌 = Ryukyu Medical Journal.  17  pp.69-72,  1997.  琉球医学会 — Ryukyu Medical Association
URL: http://hdl.handle.net/20.500.12000/0002015995
概要: Case 1 is a 61 year old male. He was admitted to Ginowan Hospital with productive cough and was thought to haveabnormal shadow on chest x-ray. He visited our hospital for further examination. We suspected thymoma and diffuse panbronchiolitis (DPB) by findings of antenor mediastinal tumor and small nodular shadow on centrilobular distribution on chest define CT. He underwent resection of mediasinal tumor and left S_10 lung biopsy. Pathological findings were thymoma and chronic bronchiolitis with infilative lymphocyte which is not compatible with DPB. Case 2 is 73 year old female, she was admitted to Izumisaki Hospital with hemosputum. Chest X-ray and CT revealed a mass in the anterior mediastinum and diffuse bronchiectasis. We could not get her permission to do further examination. We diagnosed thymoma and chronic bronchial tract infection. It is already known that thymoma complicated altered immunological response, for example myasthenia gravis and aplasticanemia. We think that immunological response with thymoma induced bronchial infection like a follicular bronchiolitis with rheumatic arthritis, might explain her condition.
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2.

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Nakasone, Hiroki ; Sgkuawa, Hiroshi ; Nakayoshi, Tmofumi ; Kawakami, Yuko ; Kinjo, Fukunori ; Saito, Atushi ; Yamashiro, Akiko ; Nakayoshi, Tmokuni ; Ikema, Minoru ; Hirayama, Yoshikatsu
出版情報: 琉球医学会誌 = Ryukyu Medical Journal.  16  pp.117-121,  1996.  琉球医学会 — Ryukyu Medical Association
URL: http://hdl.handle.net/20.500.12000/0002016002
概要: The present study examined the efficacy and the predicting factors of response to interferon (IFN) alpha in patients wit h liver cirrhosis associated with hepatitis type C virus infection (LC type C). Sixty-seven patients were treated with IFN alpha and were classified into 2 Groups. Group 1 : Patients with liver cirrhosis, showing histological liver cirrhosis or chronic active hepatitis with lobular disorganization. Group 2 : Patients with chronic hepatitis, showing histological chronic persistent hepatitis or chronic active hepatitis without lobular disorganization. Sustained response to IFN was obtained in 5/17 (29.4%) and 24/50 (48%) of patients in Group 1 and Group 2, respectively. However, the difference was not significant. All patients in Group 2 showed a significant decrease in alanine aminotransferase (ALT) levels during the treatment, whereas 5 of the 17 patients in Group 1 showed no response. All sustained responders in Group 1 who were tested for serum HCV-RNA titer showed low serum HCV-RNA titer, which was less than 10^7 copies/ml, while all except one patient of the non-responders of Group 1 showed above 10^8 copies/ml. It is said that patients with LC type C are more resistant to IFN treatment compared to those with chronic hepatitis type C. However, our findings suggest that even in patients with LC type C, low serum HCV-RNA levels might be associated with better response to IFN.
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3.

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仲吉, 朝邦 ; 池間, 稔 ; 大湾, 朝尚 ; 平山, 良克 ; 山城, 章裕 ; 前原, 信人 ; 佐久川, 廣 ; 親川, 富憲 ; 金城, 福則 ; 斎藤, 厚 ; Nakayoshi, Tomokuni ; Ikema, Minoru ; Ohwan, Tomohisa ; Hirayama, Yoshikatsu ; Yamashiro, Akihiro ; Maehara, Nobuto ; Sakugawa, Hiroshi ; Oyakawa, Tominori ; Kinjo, Fukunori ; Saito, Atushi
出版情報: 琉球医学会誌 = Ryukyu Medical Journal.  12  pp.389-393,  1992.  琉球医学会 — Ryukyu Medical Association
URL: http://hdl.handle.net/20.500.12000/0002015878
概要: A plasma concentration of PIVKA-II was measured in 19 patients with hepatocellular carcinoma (HCC), 44 with liver cirrho sis, 16 with chronic hepatitis, 11 with other benign liver diseases and 10 with other extrahepatic carcinoma. An abnormal high value of PIVKA-II was seen in 73.7% of the patients with HCC, and 40% of the patients with extrahepatic carcinoma. On the other hand, only 4.5% of patients with liver cirrhosis showed an elevated valueof PIVKA-II, and none of the patientswith both chronic hepatitis and other benign liver diseaes showed an abnormal value of PIVKA-II. Sensitivity and specificity of PIVKA-II in HCC were 73.7%, and 92.6%, respectively. Finally, we suggest that PIVKA-II would be unuseful for screening test in the early detection of HCC, because of its relatively low sensitivity against HCC. However, the test would be useful for the differencial diagnosis of the patients having space-occupying lesion in the liver.
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4.

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下地, 克佳 ; 金城, 勇徳 ; 宮城, 睦子 ; 山城, 章裕 ; 嘉数, 朝一 ; 玉城, 和則 ; 普久原, 浩 ; 中村, 浩明 ; 兼島, 洋 ; 伊良部, 勇栄 ; 重野, 芳輝 ; 斎藤, 厚 ; Shimoji, Katsuyoshi ; Kinjyo, Yutoku ; Miyagi, Mutsuko ; Yamashiro, Akihiro ; Kakazu, Tomokazu ; Tamaki, Kazunori ; Fukuhara, Hiroshi ; Nakamura, Hiroaki ; Kaneshima, Hiroshi ; Irabu, Yuei ; Shigeno, Yoshiteru ; Saito, Atushi
出版情報: 琉球大学医学会雑誌 : 医学部紀要 = Ryukyu medical journal.  11  pp.96-99,  1989.  琉球大学医学部 — Faculty of Medicine, University of the Ryukyus
URL: http://hdl.handle.net/20.500.12000/0002015786
概要: We investigated the significance of air-borne sugar cane pollen as an allergen from Sept. 1985 through Mar. 1987. The po llen from sugar cane and miscarUhus sinensis are experimentally indistinguishable under the microscope. The combined pollen count was measured, and is referred to as graminae pollen in this study. The peak pollen count for graminae was observed in late Oct. , 1985 and 1986. This coincided with the peak flowering of miscanthus sinensis. The peak flowering of sugar cane was observed from Dec. to Jan. at which time there was only a very low pollen count for graminae. Even when the pollen-collecting slides were put at two points adjacent to a sugar cane field, the pollen count was still low. Also pollen did not fall from an ear of sugar cane placed in a vase over a period of one day. The reason is that the pollen-filled sugar cane anther had not broken, and is physically difficult to break. From the above, we concluded that sugar cane pollen was not responsible as an allergen.
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