1.

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佐久川, 廣 ; 仲宗根, 啓樹 ; 仲吉, 朝史 ; 川上, 祐子 ; 諸喜田, 林 ; 新村, 政昇 ; 照屋, 寛 ; 前原, 信人 ; 金城, 渚 ; 外間, 昭 ; 大城, 淳一 ; 金城, 福則 ; 斎藤, 厚 ; 山城, 章裕 ; 上地, 博之 ; 親泊, 康朝 ; 石原, 昌清 ; 嘉手納, 啓三 ; 大湾, 朝二 ; 宮平, 守博 ; 池間, 稔 ; 仲吉, 朝邦 ; 与儀, 裕 ; 小波津, 寛 ; 中村, 博 ; 城間, 健治 ; 比嘉, 昌文 ; 平山, 良克 ; 上原, 剛 ; Sakugawa, Hiroshi ; Nakasone, Hiroki ; Nakayoshi, Tomofumi ; Kawakami, Yuko ; Shokita, Hayashi ; Niimura, Seisho ; Teruya, Hiroshi ; Maehara, Nobuto ; Kinjo, Nagisa ; Hokama, Akira ; Ohshiro, Junichi ; Kinjo, Fukunori ; Saito, Atsushi ; Yamashiro, Akihiro ; Uechi, Hiroyuki ; Oyadomari, Yasutomo ; Ishihara, Masakiyo ; Kadena, Keizo ; Ohwan, Choji ; Miyahira, Morihiro ; Ikema, Minoru ; Nakayoshi, Tomokuni ; Yogi, Yutaka ; Kohatsu, Hiroshi ; Nakamura, Hiroshi ; Shiroma, Kenji ; Higa, Masafumi ; Hirayama, Yoshikatsu ; Uehara, Takeshi
出版情報: 琉球医学会誌 = Ryukyu Medical Journal.  16  pp.71-74,  1996.  琉球医学会 — Ryukyu Medical Association
URL: http://hdl.handle.net/20.500.12000/0002015950
概要: Five different dosage regimens of recombinant interferon ($ \gamma $IFN) alfa-2 b were compared in patients with chronic hepatitis C. Ninety-four patients were assigned to one of five groups: group 1, 2 and 3 were given 3, 6 and 10 million units (MU) , respectively, of $ \gamma $IFN alfa-2b daily for 2 weeks, followed by thrice weekly for 22 weeks (total dose: 240, 480 and 800 MU) , respectively. Group 4 and 5 were given 10 MU of $ \gamma $IFN alfa-2b daily for 2 weeks, followed by 10 MU thrice weekly for 12 weeks (group 4) or 6 MU thrice weekly for 22 weeks (group 5), with a total dose of480 and 536 MU, respectively. Sustained response to $ \gamma $IFN was seen in 7.7% (1/13) of patients in group 1. The rate was significantly lower than that of either group 2 or 3 (p<0. 05 in each comparison). There was no difference in the sustained response rate between group 2 and 3 (38.0%vs 44.0%). Comparison of the efficacy of group 4 or 5 with those of the other groups was not appropriate because of the small number of patients assigned in group 4 or 5. When the sustained response rate of patients infected with genotype 1b, which was known to be resistent to IFN treatment, is compared between group 2 and 3, higher response rate was seen in group 3 (26.3% in group 2 vs 42.1% in group 3), although not significantly.
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2.

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Nakasone, Hiroki ; Sgkuawa, Hiroshi ; Nakayoshi, Tmofumi ; Kawakami, Yuko ; Kinjo, Fukunori ; Saito, Atushi ; Yamashiro, Akiko ; Nakayoshi, Tmokuni ; Ikema, Minoru ; Hirayama, Yoshikatsu
出版情報: 琉球医学会誌 = Ryukyu Medical Journal.  16  pp.117-121,  1996.  琉球医学会 — Ryukyu Medical Association
URL: http://hdl.handle.net/20.500.12000/0002016002
概要: The present study examined the efficacy and the predicting factors of response to interferon (IFN) alpha in patients wit h liver cirrhosis associated with hepatitis type C virus infection (LC type C). Sixty-seven patients were treated with IFN alpha and were classified into 2 Groups. Group 1 : Patients with liver cirrhosis, showing histological liver cirrhosis or chronic active hepatitis with lobular disorganization. Group 2 : Patients with chronic hepatitis, showing histological chronic persistent hepatitis or chronic active hepatitis without lobular disorganization. Sustained response to IFN was obtained in 5/17 (29.4%) and 24/50 (48%) of patients in Group 1 and Group 2, respectively. However, the difference was not significant. All patients in Group 2 showed a significant decrease in alanine aminotransferase (ALT) levels during the treatment, whereas 5 of the 17 patients in Group 1 showed no response. All sustained responders in Group 1 who were tested for serum HCV-RNA titer showed low serum HCV-RNA titer, which was less than 10^7 copies/ml, while all except one patient of the non-responders of Group 1 showed above 10^8 copies/ml. It is said that patients with LC type C are more resistant to IFN treatment compared to those with chronic hepatitis type C. However, our findings suggest that even in patients with LC type C, low serum HCV-RNA levels might be associated with better response to IFN.
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3.

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Sakugawa, Hiroshi ; Nakasone, Hiroki ; Kawakami, Yuko ; Nakayoshi, Tomofumi ; Kinjo, Fukunori ; Saito, Atsushi ; Ikema, Minoru ; Yamashiro, Akihiro ; Nakayoshi, Tomokuni
出版情報: 琉球医学会誌 = Ryukyu Medical Journal.  15  pp.133-137,  1995.  琉球医学会 — Ryukyu Medical Association
URL: http://hdl.handle.net/20.500.12000/0002015946
概要: To compare the clinical utility of type IV collagen 7S domain and hyaluronate, as markers in the evaluation of liver fib rosis, 184 patients with biopsy-proven chronic viral liver disease (32; type B, 152; type C) were involved in this study. The two markers correlated well with the grade of liver fibrosis. The correlation coefficients of 7S-collagen and hyaluronate with the extent of fibrosis were 0.747 and 0.813, respectively. Very high values were seen more frequently in hyaluronate than in 7S-collagen, particularly in patients with moderate and severe fibrosis. Both markers also correlated strongly with conventional liver function tests except for alanine aminotransferase. In conclusion, serum hyaluronate was a more sensitive marker and seemed to more strongly correlate with the degree of hepatic fibrosis than type IV collagen 7S domain.
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4.

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佐久川, 廣 ; 仲吉, 朝邦 ; 平山, 良克 ; 池間, 稔 ; 大湾, 朝尚 ; 山城, 章裕 ; 上地, 博之 ; 金城, 福則 ; 斎藤, 厚 ; Sakugawa, Hiroshi ; Nakayoshi, Tomokuni ; Hirayama, Yoshikatsu ; Ikema, Minoru ; Ohwan, Tomohisa ; Yamashiro, Akihiro ; Uechi, Hiroyuki ; Kinjo, Fukunori ; Saito, Atsushi
出版情報: 琉球医学会誌 = Ryukyu Medical Journal.  13  pp.173-180,  1993.  琉球医学会 — Ryukyu Medical Association
URL: http://hdl.handle.net/20.500.12000/0002015852
概要: It has been recently reported that primary Budd-Chiari syndrome (BC-S), obstruction of the hepatic portion of the inferi or vena cava, can be cured by surgical treatment, while at the same time a relatively high occurrence rate of primary hepatocellular carcinoma in BC-S has also been reported. Hence, early detection of BC-S may lead to good prognosis. To elucidate clinical characteristics of BC-S, 13 consecutive patients with the disease were investigated. The diagnosis of the syndrome was made by ultrasound, and subsequently comfirmed by cavography. Their demographic and clinical data were compared with those of patients with liver cirrhosis associated with other etiology (alcohol consumption: 25 patients, hepatitis B and/or C virus infection: 85, cryptogenic: 15). The mean age at diagnosis of the 13 patients with BC-S was $45.3 \pm 9.5$, and significantly younger than both that of patients with virus related and cryptogenic liver cirrhosis. On admission.7 of the 13 showed normal value of transaminases, and 5 0f the remaining 6 showed a slight elevation. Mean values of transaminases (GOT and GPT) on admission of patients with BC-S were significantly lower than those of each of the 3 other subgroups. Serum albumin concentrations were normal in 8 of the 13 patients, whereas all but one (who showed a very high value of serum bilirubin) had a slightly elevated value of serum bilirubin (less than 3 g/dl) on admission. Clinical features suggestive of BC-S include relatively younger age, and normal or nearly normal liver biochemical tests except for indirect domimant hyperbihrubinemia.
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5.

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諸喜田, 林 ; 平山, 良克 ; 山城, 章裕 ; 大城, 淳一 ; 池間, 稔 ; 佐久川, 廣 ; 親川, 富憲 ; 金城, 福則 ; 斎藤, 厚 ; 戸田, 隆義 ; Syokita, Hayashi ; Hirayama, Yoshikatu ; Yamashiro, Akihiro ; Ohshiro, Junichi ; Ikema, Minoru ; Sakugawa, Hiroshi ; Oyakawa, Tominori ; Kinjo, Fukunori
出版情報: 琉球医学会誌 = Ryukyu Medical Journal.  13  pp.77-82,  1993.  琉球医学会 — Ryukyu Medical Association
URL: http://hdl.handle.net/20.500.12000/0002015877
概要: Lupoid hepatitis (LH) is known as autoimmune type of chronic active hepatitis with hyper-gamma-globulinemia. However, it has recently been reported that some cases in the early phase of LH had neither hyper-gamma-globu-linemia or chronic active hepatitis of the liver. Two interesting cases with LH were presented here, who had been observed from the onsets of the diseases. One case, a 69-year-old female visited our hospital, complaining of general malaise and jaundice. On admission, liver biochemical tests showed very high value of serum transaminases and slightly elevated gamma globulin (but less than 2.0 g/dl). The initially biopsied specimen of the liver showed focal necrosis and ballooning liver cells in the lobule but no evidence of piece-meal necrosis in the portal area of the liver. These findings were not compatible with those of LH. Then, she was diagnosed as having acute hepatitis associated with hepatitis infected with non A non B virus. Her serum transaminases subsequently fell into normal range. However, she suffered from the recurrence of hepatitis and was admitted to our hospital again. The second liver biopsy showed the findings of intensive piece-meal necrosis which were consistent with those of LH. The other case was a 54-year-old woman. At first, she was pointed out abnormal liver function tests through medical exanimation and referred to our hospital for further examination. Her laboratory findings on admission showed moderately elevated transaminases. but negative reaction of anti-nuclear antibody. She underwent liver biopsy that revealed findings being consistent with chronic persistent hepatitis. After six month, she was admitted our hospital again for elevation of serum transaminases. The second liver biopsy was performed and showed severe piece-meal necrosis of the liver.
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6.

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仲吉, 朝邦 ; 池間, 稔 ; 大湾, 朝尚 ; 平山, 良克 ; 山城, 章裕 ; 前原, 信人 ; 佐久川, 廣 ; 親川, 富憲 ; 金城, 福則 ; 斎藤, 厚 ; Nakayoshi, Tomokuni ; Ikema, Minoru ; Ohwan, Tomohisa ; Hirayama, Yoshikatsu ; Yamashiro, Akihiro ; Maehara, Nobuto ; Sakugawa, Hiroshi ; Oyakawa, Tominori ; Kinjo, Fukunori ; Saito, Atushi
出版情報: 琉球医学会誌 = Ryukyu Medical Journal.  12  pp.389-393,  1992.  琉球医学会 — Ryukyu Medical Association
URL: http://hdl.handle.net/20.500.12000/0002015878
概要: A plasma concentration of PIVKA-II was measured in 19 patients with hepatocellular carcinoma (HCC), 44 with liver cirrho sis, 16 with chronic hepatitis, 11 with other benign liver diseases and 10 with other extrahepatic carcinoma. An abnormal high value of PIVKA-II was seen in 73.7% of the patients with HCC, and 40% of the patients with extrahepatic carcinoma. On the other hand, only 4.5% of patients with liver cirrhosis showed an elevated valueof PIVKA-II, and none of the patientswith both chronic hepatitis and other benign liver diseaes showed an abnormal value of PIVKA-II. Sensitivity and specificity of PIVKA-II in HCC were 73.7%, and 92.6%, respectively. Finally, we suggest that PIVKA-II would be unuseful for screening test in the early detection of HCC, because of its relatively low sensitivity against HCC. However, the test would be useful for the differencial diagnosis of the patients having space-occupying lesion in the liver.
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