1.

論文(リポジトリ)

論文(リポジトリ)
佐久川, 廣 ; 仲宗根, 啓樹 ; 仲吉, 朝史 ; 川上, 祐子 ; 諸喜田, 林 ; 新村, 政昇 ; 照屋, 寛 ; 前原, 信人 ; 金城, 渚 ; 外間, 昭 ; 大城, 淳一 ; 金城, 福則 ; 斎藤, 厚 ; 山城, 章裕 ; 上地, 博之 ; 親泊, 康朝 ; 石原, 昌清 ; 嘉手納, 啓三 ; 大湾, 朝二 ; 宮平, 守博 ; 池間, 稔 ; 仲吉, 朝邦 ; 与儀, 裕 ; 小波津, 寛 ; 中村, 博 ; 城間, 健治 ; 比嘉, 昌文 ; 平山, 良克 ; 上原, 剛 ; Sakugawa, Hiroshi ; Nakasone, Hiroki ; Nakayoshi, Tomofumi ; Kawakami, Yuko ; Shokita, Hayashi ; Niimura, Seisho ; Teruya, Hiroshi ; Maehara, Nobuto ; Kinjo, Nagisa ; Hokama, Akira ; Ohshiro, Junichi ; Kinjo, Fukunori ; Saito, Atsushi ; Yamashiro, Akihiro ; Uechi, Hiroyuki ; Oyadomari, Yasutomo ; Ishihara, Masakiyo ; Kadena, Keizo ; Ohwan, Choji ; Miyahira, Morihiro ; Ikema, Minoru ; Nakayoshi, Tomokuni ; Yogi, Yutaka ; Kohatsu, Hiroshi ; Nakamura, Hiroshi ; Shiroma, Kenji ; Higa, Masafumi ; Hirayama, Yoshikatsu ; Uehara, Takeshi
出版情報: 琉球医学会誌 = Ryukyu Medical Journal.  16  pp.71-74,  1996.  琉球医学会 — Ryukyu Medical Association
URL: http://hdl.handle.net/20.500.12000/0002015950
概要: Five different dosage regimens of recombinant interferon ($ \gamma $IFN) alfa-2 b were compared in patients with chronic hepatitis C. Ninety-four patients were assigned to one of five groups: group 1, 2 and 3 were given 3, 6 and 10 million units (MU) , respectively, of $ \gamma $IFN alfa-2b daily for 2 weeks, followed by thrice weekly for 22 weeks (total dose: 240, 480 and 800 MU) , respectively. Group 4 and 5 were given 10 MU of $ \gamma $IFN alfa-2b daily for 2 weeks, followed by 10 MU thrice weekly for 12 weeks (group 4) or 6 MU thrice weekly for 22 weeks (group 5), with a total dose of480 and 536 MU, respectively. Sustained response to $ \gamma $IFN was seen in 7.7% (1/13) of patients in group 1. The rate was significantly lower than that of either group 2 or 3 (p<0. 05 in each comparison). There was no difference in the sustained response rate between group 2 and 3 (38.0%vs 44.0%). Comparison of the efficacy of group 4 or 5 with those of the other groups was not appropriate because of the small number of patients assigned in group 4 or 5. When the sustained response rate of patients infected with genotype 1b, which was known to be resistent to IFN treatment, is compared between group 2 and 3, higher response rate was seen in group 3 (26.3% in group 2 vs 42.1% in group 3), although not significantly.
論文
続きを見る
2.

論文(リポジトリ)

論文(リポジトリ)
Nakasone, Hiroki ; Sgkuawa, Hiroshi ; Nakayoshi, Tmofumi ; Kawakami, Yuko ; Kinjo, Fukunori ; Saito, Atushi ; Yamashiro, Akiko ; Nakayoshi, Tmokuni ; Ikema, Minoru ; Hirayama, Yoshikatsu
出版情報: 琉球医学会誌 = Ryukyu Medical Journal.  16  pp.117-121,  1996.  琉球医学会 — Ryukyu Medical Association
URL: http://hdl.handle.net/20.500.12000/0002016002
概要: The present study examined the efficacy and the predicting factors of response to interferon (IFN) alpha in patients wit h liver cirrhosis associated with hepatitis type C virus infection (LC type C). Sixty-seven patients were treated with IFN alpha and were classified into 2 Groups. Group 1 : Patients with liver cirrhosis, showing histological liver cirrhosis or chronic active hepatitis with lobular disorganization. Group 2 : Patients with chronic hepatitis, showing histological chronic persistent hepatitis or chronic active hepatitis without lobular disorganization. Sustained response to IFN was obtained in 5/17 (29.4%) and 24/50 (48%) of patients in Group 1 and Group 2, respectively. However, the difference was not significant. All patients in Group 2 showed a significant decrease in alanine aminotransferase (ALT) levels during the treatment, whereas 5 of the 17 patients in Group 1 showed no response. All sustained responders in Group 1 who were tested for serum HCV-RNA titer showed low serum HCV-RNA titer, which was less than 10^7 copies/ml, while all except one patient of the non-responders of Group 1 showed above 10^8 copies/ml. It is said that patients with LC type C are more resistant to IFN treatment compared to those with chronic hepatitis type C. However, our findings suggest that even in patients with LC type C, low serum HCV-RNA levels might be associated with better response to IFN.
論文
続きを見る
3.

論文(リポジトリ)

論文(リポジトリ)
山城, 章裕 ; 佐久川, 廣 ; 平山, 良克 ; 大湾, 朝尚 ; 仲吉, 朝邦 ; 池間, 稔 ; 親川, 富憲 ; 嘉手納, 啓三 ; 金城, 福則 ; 斎藤, 厚 ; Yamashiro, Akihiro ; Sakugawa, Hiroshi ; Hirayama, Yoshikatsu ; Ohwan, Tomohisa ; Nakayoshi, Tomokuni ; lkema, Minoru ; Oyakawa, Tominori ; Kadena, Keizo ; Kinjo, Fukunori ; Saito, Atsushi
出版情報: 琉球医学会誌 = Ryukyu Medical Journal.  13  pp.55-61,  1993.  琉球医学会 — Ryukyu Medical Association
URL: http://hdl.handle.net/20.500.12000/0002015844
概要: Two cases of Wilson's disease in sibrings were reported. On admission, their general conditions were quite well and they had mild symptoms suggesting chronic liver disease. They underwent ultrasound (US), computed tomography (CT), laparoscopy and liverbiopsy. In these examinations, no characteristic findings for the diagnosis of Wilson's disease was obtained. US showed relatively hypoechoic liver parenchyma and several echogenic linear shadow, which might present the walls of the peripheral portal branches or peripheral portal area, in the parenchyma of both cases. CT showed several high density nodules in the parenchyma of both of the livers, which were surrounded low density area. From these US and CT findings, they were suspected as having severe or advanced liver cirrhosis unless they had mild symptoms and well condition. Subsequently, laparoscopy and liver biopsy revealed advanced cirrhotic lesion in their liver.
論文
続きを見る
4.

論文(リポジトリ)

論文(リポジトリ)
佐久川, 廣 ; 仲吉, 朝邦 ; 平山, 良克 ; 池間, 稔 ; 大湾, 朝尚 ; 山城, 章裕 ; 上地, 博之 ; 金城, 福則 ; 斎藤, 厚 ; Sakugawa, Hiroshi ; Nakayoshi, Tomokuni ; Hirayama, Yoshikatsu ; Ikema, Minoru ; Ohwan, Tomohisa ; Yamashiro, Akihiro ; Uechi, Hiroyuki ; Kinjo, Fukunori ; Saito, Atsushi
出版情報: 琉球医学会誌 = Ryukyu Medical Journal.  13  pp.173-180,  1993.  琉球医学会 — Ryukyu Medical Association
URL: http://hdl.handle.net/20.500.12000/0002015852
概要: It has been recently reported that primary Budd-Chiari syndrome (BC-S), obstruction of the hepatic portion of the inferi or vena cava, can be cured by surgical treatment, while at the same time a relatively high occurrence rate of primary hepatocellular carcinoma in BC-S has also been reported. Hence, early detection of BC-S may lead to good prognosis. To elucidate clinical characteristics of BC-S, 13 consecutive patients with the disease were investigated. The diagnosis of the syndrome was made by ultrasound, and subsequently comfirmed by cavography. Their demographic and clinical data were compared with those of patients with liver cirrhosis associated with other etiology (alcohol consumption: 25 patients, hepatitis B and/or C virus infection: 85, cryptogenic: 15). The mean age at diagnosis of the 13 patients with BC-S was $45.3 \pm 9.5$, and significantly younger than both that of patients with virus related and cryptogenic liver cirrhosis. On admission.7 of the 13 showed normal value of transaminases, and 5 0f the remaining 6 showed a slight elevation. Mean values of transaminases (GOT and GPT) on admission of patients with BC-S were significantly lower than those of each of the 3 other subgroups. Serum albumin concentrations were normal in 8 of the 13 patients, whereas all but one (who showed a very high value of serum bilirubin) had a slightly elevated value of serum bilirubin (less than 3 g/dl) on admission. Clinical features suggestive of BC-S include relatively younger age, and normal or nearly normal liver biochemical tests except for indirect domimant hyperbihrubinemia.
論文
続きを見る
5.

論文(リポジトリ)

論文(リポジトリ)
佐久川, 廣 ; 山城, 章裕 ; 大湾, 朝尚 ; 平山, 良克 ; 上地, 博之 ; 親川, 富憲 ; 上原, 剛 ; 志喜屋孝伸 ; 新垣, 民樹 ; 金城, 福則 ; 斎藤, 厚 ; Sakugawa, Hiroshi ; Yamashiro, Akihiro ; Oowan, Tomohisa ; Hirayama, Yoshikatsu ; Uechi, Hiroyuki ; Oyakawa, Tominori ; Uehara, Tsuyoshi ; Shikiya, Koushin ; Arakaki, Tamiki ; Kinjo, Fukunori ; Saito, Atsushi
出版情報: 琉球医学会誌 = Ryukyu Medical Journal.  12  pp.142-148,  1992.  琉球医学会 — Ryukyu Medical Association
URL: http://hdl.handle.net/20.500.12000/0002015858
概要: It is recently said that ultrasonography (US) has been useful for the diagnosis of several liver disease including liver cirrhosis and fatty liver. In order to evaluate objectively the degree of progression of long-standing liver disease by US, the findings of portal hypertension were assessed. The subjects of this study consisted of 93 healthy controls, 89 asymptomatic hepatitis B virus carriers, 41 patients with fatty liver, 42 chronic hepatitis or liver fibrosis and 72 liver cirrhosis. To evaluate the degree of portal hypertension, several measurements were carried out , which included the diameter of portal vein and splenic vein, and the size of the spleen. In addition, theprCsence of portosystemic collateral veins were assessed. In the patients with liver cirrhosis , splenomegaly was the leading abnormality with being found in 75% of them, and secondly excess size of the diameter of the splenic vein at the hilum of the spleen was seen in52.8% of them. The other findings (i. e. excess size of the diameter of the portal main trunk, left side splenic vein and splenic vein in the intrasplenic portion) were less frequent. Among the other clinical groups, these abnormal findings were found in few cases. Splenomegaly, the excess size of the diameter of the splenic vein at the hilum of the spleen and the presence of portosystemic collateral veins were considered to be useful for the diagnosis both of portal hypertension and liver cirrhosis. In this study, 86.1% of the patients with liver cirrhosis showed one or more of the such abnormalities.
論文
続きを見る
6.

論文(リポジトリ)

論文(リポジトリ)
仲吉, 朝邦 ; 諸喜田, 林 ; 平敷, 健 ; 平山, 良克 ; 大城, 淳一 ; 佐久川, 廣 ; 金城, 福則 ; 斎藤, 厚 ; Nakayoshi, Tomokuni ; Syokita, Hayashi ; Heshiki, Takeshi ; Hirayama, Yoshikatsu ; Oshiro, Junichi ; Sakugawa, Hiroshi ; Kinjo, Fukunori ; Saito, Atsushi
出版情報: 琉球医学会誌 = Ryukyu Medical Journal.  12  pp.395-399,  1992.  琉球医学会 — Ryukyu Medical Association
URL: http://hdl.handle.net/20.500.12000/0002015860
概要: Serum alpha-fetoprotein(AFP) is generally recognized to be useful as a tumor marker for hepatocellular carcinoma. But th e fact that some cases of benign liver diseases (eg.chronic active hepatitis, liver cirrhosis, etc), or some of extra hepatic malignancies show high serum level of AFP is also well known. We presented here a case of 60-year-old female, who showed very high value of serum AFP, and no evidence of hepatocellular carcinoma. She admitted our hospital for further examination of abnormal increasing of serum AFP. Her serum AFP concentration subsequently increased up to 1359 ng/ml following with high elevated serum transaminase, and the both decreased after treatment. Ultrasonography, computed tomography, drip infusion chorangigraphy, and abdominal arteriography showed no space-occupying-lesion in the liver. Gastroduodenal endoscopy and barium enema were also carried out and no tumorous lesion was detected. These studies denied presence of hepatocellular carcinoma, or ectopic AFP producing tumors. She was received liver biopsy, and was diagnosed as having chronic aggresive hepatitis. Lectin affinities of the increased AFP showed concanavalin A(conA)-reactive, and lentil lectin(LCA)- non reactive. These findings suggested that the increased AFP would be caused by regeneration process of hepatic cells after the necrosis of unknown etiology.
論文
続きを見る
7.

論文(リポジトリ)

論文(リポジトリ)
仲吉, 朝邦 ; 池間, 稔 ; 大湾, 朝尚 ; 平山, 良克 ; 山城, 章裕 ; 前原, 信人 ; 佐久川, 廣 ; 親川, 富憲 ; 金城, 福則 ; 斎藤, 厚 ; Nakayoshi, Tomokuni ; Ikema, Minoru ; Ohwan, Tomohisa ; Hirayama, Yoshikatsu ; Yamashiro, Akihiro ; Maehara, Nobuto ; Sakugawa, Hiroshi ; Oyakawa, Tominori ; Kinjo, Fukunori ; Saito, Atushi
出版情報: 琉球医学会誌 = Ryukyu Medical Journal.  12  pp.389-393,  1992.  琉球医学会 — Ryukyu Medical Association
URL: http://hdl.handle.net/20.500.12000/0002015878
概要: A plasma concentration of PIVKA-II was measured in 19 patients with hepatocellular carcinoma (HCC), 44 with liver cirrho sis, 16 with chronic hepatitis, 11 with other benign liver diseases and 10 with other extrahepatic carcinoma. An abnormal high value of PIVKA-II was seen in 73.7% of the patients with HCC, and 40% of the patients with extrahepatic carcinoma. On the other hand, only 4.5% of patients with liver cirrhosis showed an elevated valueof PIVKA-II, and none of the patientswith both chronic hepatitis and other benign liver diseaes showed an abnormal value of PIVKA-II. Sensitivity and specificity of PIVKA-II in HCC were 73.7%, and 92.6%, respectively. Finally, we suggest that PIVKA-II would be unuseful for screening test in the early detection of HCC, because of its relatively low sensitivity against HCC. However, the test would be useful for the differencial diagnosis of the patients having space-occupying lesion in the liver.
論文
続きを見る
8.

論文(リポジトリ)

論文(リポジトリ)
平山, 良克 ; 外間, 昭 ; 澤岻, 安教 ; 上地, 博之 ; 志喜星, 孝伸 ; 佐久川, 廣 ; 嘉手納, 啓三 ; 金城, 福則 ; 斎藤, 厚 ; 戸田, 隆義 ; Hirayama, Yoshikatsu ; Hokama, Akira ; Takushi, Yasunori ; Shikiya, Kohshin ; Sakugawa, Hiroshi ; Kadena, Keizo ; Kinjo, Fukunori ; Saito, Atsushi ; Toda, Takayoshi
出版情報: 琉球大学医学会雑誌 : 医学部紀要 = Ryukyu medical journal.  11  pp.108-112,  1989.  琉球大学医学部 — Faculty of Medicine, University of the Ryukyus
URL: http://hdl.handle.net/20.500.12000/0002015788
概要: A 69-year old female was complaint with high fever, cough, anorexia and general malaise. At admission, her liver functio n tests showed elevated s-GOT and s-GPT, and she was suspected to have acute hepatitis. Serological examination showed negative for both IgM-anti-HA and IgM-anti-HBc, high value of $ \gamma $-globulin and positive test for autoantibodies which suggested chronic active hepatitis such as lupoid hepatitis. However, histologically, the liver tissue did not show piecemeal necrosis or fibrosis which are compatible for diagnosis of chronic active lupoid hepatitis. There was no history of alcoholism nor drug ingestion. Therefore, non A non B type of acute hepatitis with high value of $ \gamma $-globulin and positive tests for autoantibodies was most likely in this case.
論文
続きを見る