[原著]Predicting factors and efficacy of interferon alpha therapy in patients with liver cirrhosis associated with HCV infection

資料種別:
論文(リポジトリ)
責任表示:
Nakasone, Hiroki ; Sgkuawa, Hiroshi ; Nakayoshi, Tmofumi ; Kawakami, Yuko ; Kinjo, Fukunori ; Saito, Atushi ; Yamashiro, Akiko ; Nakayoshi, Tmokuni ; Ikema, Minoru ; Hirayama, Yoshikatsu
言語:
英語
出版情報:
琉球医学会 — Ryukyu Medical Association, 1996
著者名:
Nakasone, Hiroki
Sgkuawa, Hiroshi
Nakayoshi, Tmofumi
Kawakami, Yuko
Kinjo, Fukunori
Saito, Atushi
Yamashiro, Akiko
Nakayoshi, Tmokuni
Ikema, Minoru
Hirayama, Yoshikatsu
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掲載情報:
琉球医学会誌 = Ryukyu Medical Journal
ISSN:
1346888X  CiNii Research  Webcat Plus  JAIRO
0289-1530  CiNii Research  Webcat Plus  JAIRO
巻:
16
通号:
3
開始ページ:
117
終了ページ:
121
バージョン:
VoR
概要:
The present study examined the efficacy and the predicting factors of response to interferon (IFN) alpha in patients with liver cirrhosis associated with hepatitis type C virus infection (LC type C). Sixty-seven patients were treated with I FN alpha and were classified into 2 Groups. Group 1 : Patients with liver cirrhosis, showing histological liver cirrhosis or chronic active hepatitis with lobular disorganization. Group 2 : Patients with chronic hepatitis, showing histological chronic persistent hepatitis or chronic active hepatitis without lobular disorganization. Sustained response to IFN was obtained in 5/17 (29.4%) and 24/50 (48%) of patients in Group 1 and Group 2, respectively. However, the difference was not significant. All patients in Group 2 showed a significant decrease in alanine aminotransferase (ALT) levels during the treatment, whereas 5 of the 17 patients in Group 1 showed no response. All sustained responders in Group 1 who were tested for serum HCV-RNA titer showed low serum HCV-RNA titer, which was less than 10^7 copies/ml, while all except one patient of the non-responders of Group 1 showed above 10^8 copies/ml. It is said that patients with LC type C are more resistant to IFN treatment compared to those with chronic hepatitis type C. However, our findings suggest that even in patients with LC type C, low serum HCV-RNA levels might be associated with better response to IFN.
論文
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URL:
http://hdl.handle.net/20.500.12000/0002016002
電子版
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