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図書 |
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木村靖二, 岸本美緒, 小松久男監修
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天児, 慧(1947-)
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現代行政法講座編集委員会編
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Michael Dine
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edited and introduced by Peter Catapano and Rosemarie Garland-Thomson ; foreword by Andrew Solomon
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雑誌 |
雑誌
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杏林大学 [編] = Kyorin University
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池澤夏樹編
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[紫式部著] ; 角田光代訳
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岸本誠司, 村上信五, 春名眞一編集
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Jennifer L. Eberhardt
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Carol Gilligan, David A.J. Richards
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図書
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松本伊智朗編集代表
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オウィディウス [著] ; 高橋宏幸訳
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松尾葦江編
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K. P. C. Vollhardt, N. E. Schore [著] ; 大嶌幸一郎 [ほか] 訳
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土居英二, 浅利一郎, 中野親徳編著
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図書
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田上智宜, 松田康博編
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雑誌 |
雑誌
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海洋研究開発機構
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雑誌
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ピエール・ブルデュー編
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平野裕之著
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| 25.
論文（リポジトリ） |
論文（リポジトリ）
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髙良, 美沙希 ; 大田, 伊久雄 ; 木島, 真志 ; Takara, Misaki ; Ota, Ikuo ; Konoshima, Masashi
概要:
木育とは2004年に北海道で誕生した「日常に木を取り入れる」取組である．沖縄県では，2014年に策定された「沖縄県森林・林業アクションプラン」において県産材の利用促進という観点から木育を推進しており，県内各地で様々な木育活動が展開されている
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．本研究では，県内で木育活動を実施している様々な団体への聞き取り調査と，木育イベントへの参加者などに対するアンケート調査をもとに，県内の木育活動の現状と課題を明らかにし，今後の沖縄県に必要な木育の展開について考察することを目的とした．聞き取り調査の結果から県内の木育活動の目的は林業振興・環境教育・幼少教育の3つに分類できることが分かった．また，木育講座の要望は増加傾向にあるものの，木育を担う人材が不足していることが明らかになった．木育イベント参加者へのアンケート調査の結果からは，森林散策や動植物の観察会等，森林を活用したイベントなどが望まれていることが明らかになり，現状の木工体験を中心とした木育活動に加えて新たなメニュー開発が課題であることが分かった．
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| 26.
論文（リポジトリ） |
論文（リポジトリ）
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金城, 光菜野 ; 木島, 真志 ; 大田, 伊久雄 ; Kinjo, Hinano ; Konoshima, Masashi ; Ota, Ikuo
概要:
日本国内における戸建住宅の多くは木造であるが，沖縄県だけは例外的にRC造が主流であり，木造住宅は極めて少ない．しかし，近年では県内でも木造住宅の着工戸数が増加してきており，2017年には1,000戸を超え，戸建て住宅における木造率も35％に
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まで増加している．そこで本研究では，沖縄県における木造住宅生産者を探し出して聞き取り調査を行い，誰がどのような工法でどれだけの木造住宅を建てているのかの実態を把握した．その結果，沖縄県内の木造住宅生産者は大別して県内の建築業者と県外の建築業者に分けられ，どちらも同程度の建築戸数実績となっていることがわかった．ただし，県内業者では年間建築戸数が20戸以下の比較的小規模な業者と20戸以上の大規模業者が拮抗しているのに対し，県外業者では圧倒的に大規模業者による建築実績が大きいことが判明した．さらに，多くの生産者が2008年以降に木造住宅の建築を開始しており，木造住宅建築に関わる業者数が急激に増加していることがわかった．現状における木造住宅の普及に関する問題点としては，人材不足，施工側の取り組み意識の消極性，消費者側の木造に対する不信感の払拭などが挙げられる．今後も沖縄県における木造住宅木造着工数は増加を続けることが見込まれるが，木造住宅を支える人材の育成や沖縄仕様の家づくりの研究，さらに木造住宅の安全性についての積極的なPR等が必要である．
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| 27.
論文（リポジトリ） |
論文（リポジトリ）
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芝, 正己 ; Shiba, Masami
概要:
Der Schlüssel zur Forstästhetik liegt in der Idee, die Holzproduktionsaktivitäten mit der Schaffung wunderschöner Wälder
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in Einklang zu bringen, d. h. "Harmonie zwischen Wirtschaftlichkeit und Schönheit von Bewirtschaftungsforst".Dieser Gedanke wird im Kontext sozioökonomischer und kultureller Fragestellungen zum Umgang mit Wäldern diskutiert, die im Laufe der 100-jährigen deutschen Waldentwicklung einen hohen ökonomischen Stellenwert haben und die dadurch verloren gegangene Schönheit der regionalen Landschaft widerspiegeln. Es wurde von Riches Buch und seiner tatsächlichen Waldschöpfung genährt. Schließlich wird die Forstästhetik von der Gesellschaft durch die Heimatschutzbewegung bewertet und akzeptiert, eine sogenannte lokale Landschaft, die sich aus deutschem Naturschutz, Ackerland und Wäldern zusammensetzt. In diesem Aufsatz habe ich zunächst den Hintergrund der Entstehung der Forstästhetik in Bezug auf den Entwicklungsprozess der deutschen Forstwirtschaft und verwandter Gebiete wie Aufklärung und Romantik erörtert, die sich zu dieser Zeit hauptsächlich in Europa entwickelten. Insbesondere durch Goethes Amtsgeschäfte als Gerichtsberater während der Weimarer Zeit verwies er auf den Austausch mit Forstklassiker „ Cotta“ und „König“ sowie anderen wichtigen Oberforestmeister, Wildmeister und Hofjäger, und auf Verbindungen zu Ausschüssen für Forst- und Jagdwirtschaft.Schließlich betrachte ich entstand 1902 das Buch『Forstästhetik』von Salish und 2005 das Buch 『Waldästhetik über Forstwirtschaft, Naturschuzt und die Menschenseele』 von Stölb, aus der Perspektive einer inhaltlichen Neufassung－Umschrift oder Transkription.
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| 28.
論文（リポジトリ） |
論文（リポジトリ）
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仲間, 勇栄 ; Nakama, Yuei
概要:
The campus of the University of the Ryukyus is approximately 1.26 million square meters at present. It spans three admin
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istrative districts: Nishihara Town, Nakagusuku Village, and Ginowan City. Before relocation, the area was a forest mainly owned by Nishihara Town and Nakagusuku Village. The Nishihara forest was called “Tanabaruyama” during the Ryukyu Kingdom period, and it was a “Somayama” where tea gardens and trees planted exclusively for the Kingdom were cared by the Imperial Palace of Shuri. “Somayama” means the mountain that provided the kingdom with wood. Since the Senbaru campus stratum contained old formations such as old Yanbaru-type Nago and Kayo strata, plants like Itajii (Castanopsis sieboldii), Okinawa Urajirogashi (Quercus miyagii), etc. found in acidic soils of Yambaru were used to be growing. However, due to topographical changes, the Itajii trees have now disappeared and only a few Okinawa Urajirogashi can be seen around Senbaru Pond. In this Senbaru district, the mountain managers began to live during the period of the Ryukyu Kingdom, and many migrants from Shuri have settled in since Meiji era. These settlers used to live along the river in Senbaru, making use of the blessings bestowed by the rivers and mountains until around the late 1960s before the University of the Ryukyus moved. They lived mainly by growing sugarcane. Even now, the Ryukyu Kingdom’s tea garden, wells, sacred places, tombs, ruins, and the many traces of life the people who settled there in later years are still left behind in this Senbaru campus. Now, few people know the historical sites still there. I believe that restoring the history and culture of our roots and conveying these to students will be a place for rediscovering living science and also a fundamental part of university education.
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| 29.
論文（リポジトリ） |
論文（リポジトリ）
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新里, 孝和 ; 陳, 碧霞 ; 芝, 正巳 ; Shinzato, Takakazu ; Chen, Bixia ; Shiba, Masami
概要:
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| 30.
論文（リポジトリ） |
論文（リポジトリ）
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Horie, Miki ; Takaragawa, Hiroo ; Kawamitsu, Yoshinobu
概要:
In order to shorten the cultivation period of pineapple, a crassulacean acid metabolism (CAM) plant, it is important to
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increase the rate of CO2 exchange rate and improve dry matter production, especially at the early growth stage. When plants are grown under hydroponic conditions, absorption of nutrients and plant water availability are generally increased, and in the case of CAM plants, hydroponics could be expected to improve growth rate through promoting stomatal open during daytime. The objective of this study was to examine the effect of culture method (hydroponic and soil culture) on diurnal changes in gas exchange rate and CO2 balance in pineapple. The daily CO2 balance under hydroponics tended to be higher than under soil culture, especially in Phase-4. This was due to a shortened Phase-3 and a prolonged Phase-4 under hydroponics compared to soil culture. In Phase-4, the CO2 exchange rate was significantly correlated with stomatal conductance, indicating CO2 balance was affected by stomatal activity. Rubisco consumption activated under hydroponic culture may have shortened the duration of Phase-3 when stomatal opening was suppressed. The CO2 balance tended to be increased because of the shortening of Phase-3, resulting in higher dry matter productivity. From these results, it is suggested that hydroponic culture could promote growth in pineapple. However, net assimilation rate under soil culture was equivalent to that under hydroponics. Further study is needed to reveal the relationship between hydroponic cultivation and whole-plant photosynthetic ability.
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| 31.
論文（リポジトリ） |
論文（リポジトリ）
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関根, 健太郎 ; 綱取, 汐音 ; 斎藤, 明莉 ; 諏訪, 竜一 ; 田場, 聡 ; Sekine, Ken-Taro ; Tsunatori, Shion ; Saito, Akari ; Suwa, Ryuichi ; Taba, Satoshi
概要:
Agriculture in Okinawa, an area located in the subtropical climate zone, is pest prone owing to the warm and humid clima
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te of the region. While it is possible to produce crops with high market demand using differences in climatic zones—cultivated products varying regionally—, the cultivation system in each location is unique. In addition, there is a paucity of basic academic knowledge to facilitate improvements in agricultural productivity. In order to promote regional agriculture, it is essential to gather technologies and knowledge from universities, national and prefectural research institutions, and private companies, to work together to solve the problems and meet the needs of local producers. It is also crucial to develop leaders to promote regional agriculture development. Therefore, the University of the Ryukyus has established the Okinawa Crop Protection Network, to share information on agricultural issues among industry, academia, and the private sector. The aim is to build a collaborative research network that contributes to regional development, and to use this network as a basis for human resource development to groom local leaders. This paper describes the history and future prospects of this vital network
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| 32.
論文（リポジトリ） |
論文（リポジトリ）
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谷口, 真吾 ; 松本, 一穂 ; Bam, Razafindrabe ; 亀山, 統一 ; Taniguchi, Shingo ; Matumoto, Kazuho ; Kameyama, Norikazu
概要:
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| 33.
論文（リポジトリ） |
論文（リポジトリ）
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酒井, 一人 ; 仲村渠, 将 ; Sakai, Kazuhito ; Nakandakari, Tamotsu
概要:
利水工学研究室の赤土流出研究は名誉教授吉永安俊先生の取組みに端を発している．本報告では，その当時から今日に至るまでの赤土流出を研究する取組みを紹介した．
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| 34.
論文（リポジトリ） |
論文（リポジトリ）
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木村, 匠 ; Kimura, Sho
概要:
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| 35.
論文（リポジトリ） |
論文（リポジトリ）
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平良, 英三 ; 鹿内, 健志 ; Taira, Eizo ; Shikanai, Takeshi
概要:
バイオシステム工学分野では，農業機械学，農業情報工学，農産施設工学を基礎とする講義科目を提供している．亜熱帯島嶼環境に適した機械化と情報化を核とする高度農業生産技術，バイオマス利用技術，農産物などの加工・高付加価値化技術の研究開発を行ってお
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り，近年は，スマート農業やスマート・フードチェーンシステムとして注目されている．
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| 36.
論文（リポジトリ） |
論文（リポジトリ）
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波平, 知之 ; 陳, 碧霞 ; モハメドアムザド, ホサイン ; 赤嶺, 光 ; 高嶋, 敦史 ; Namihira, Tomoyuki ; Chen, Bixia ; Mohammad Amzad, Hossain ; Akamine, Hikaru ; Takashima, Atsushi
概要:
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| 37.
論文（リポジトリ） |
論文（リポジトリ）
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Sudo, Takahiro
概要:
We would like to review and study the basic noncommutative geometry by Khalkhali, but only partially as contained in the first chapter.
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| 38.
論文（リポジトリ） |
論文（リポジトリ）
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Kise, Yuya ; Kuniyoshi, Yukio ; Ando, Mizuki ; Maeda, Tatuya ; Inafuku, Hitoshi ; Yamashiro, Satoshi
概要:
Deep hypothermia in thoracoabdominal aortic aneurysm operations is considered extremely useful for ensuring sufficient time to reconstruct the segmental arteries feeding the spinal cord. However, because the amplitude of motor evoked
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potentials (MEPs) decrease or disappear during deep hypothermia, feasible methods for assessing spinal cord circulation have not yet been reported. Performing additional segmental arterial reconstructions that rely on MEPs is also impractical. In the present case, to ascertain spinal cord circulation under deep hypothermia, we intraoperatively measured the reconstructed segmental arterial pressure in real time and investigated whether sufficient spinal cord blood flow had been attained.
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| 39.
学位論文（リポジトリ） |
学位
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Abe, Norie ; 阿部, 典恵
概要:
As visual quantification of the density of tumor-infiltrating lymphocytes (TILs) lacks in precision, digital image analy
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sis (DIA) approach has been applied in order to improve. In several studies, TIL density has been examined on hematoxylin and eosin (HE)-stained sections using DIA. The aim of the present study was to quantify TIL density on HE sections of core needle biopsies using DIA and investigate its association with clinicopathological parameters and pathological response to neoadjuvant chemotherapy in human epidermal growth factor receptor 2 (HER2)-positive breast cancer. The study cohort comprised of patients with HER2-positive breast cancer, all treated with neoadjuvant anti-HER2 therapy. DIA software applying machine learning-based classification of epithelial and stromal elements was used to count TILs. TIL density was determined as the number of TILs per square millimeter of stromal tissue. Median TIL density was 1287/mm^2 (range, 123–8101/mm^2). A high TIL density was associated with higher histological grade (P = 0.02), estrogen receptor negativity (P = 0.036), and pathological complete response (pCR) (P < 0.0001). In analyses using receiver operating characteristic curves, a threshold TIL density of 2420/mm^2 best discriminated pCR from non-pCR. In multivariate analysis, high TIL density (> 2420/mm^2) was significantly associated with pCR (P < 0.0001). Our results indicate that DIA can assess TIL density quantitatively, machine learning-based classification algorithm allowing determination of TIL density as the number of TILs per unit area, and TIL density established by this method appears to be an independent predictor of pCR in HER2-positive breast cancer.
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| 40.
論文（リポジトリ） |
論文（リポジトリ）
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Rosenberg, Yael ; Doniger, Tirza ; Harii, Saki ; Sinniger, Frederic ; Levy, Oren
概要:
Life on earth has evolved under constant environmental changes; in response to these changes, most organisms have develo
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ped an endogenous clock that allows them to anticipate daily and seasonal changes and adapt their biology accordingly. Light cycles synchronize biological rhythms and are controlled by an endogenous clock that is entrained by environmental cues. Light is known to play a key role in the biology of symbiotic corals as they exhibit many biological processes entrained by daily light patterns. In this study, we aimed at determining the effect of constant dim light on coral's perception of diel and monthly cycles. Our results show that under constant dim light corals display a loss of rhythmic processes and constant stimuli by light, which initiates signal transduction that results in an abnormal cell cycle, cell proliferation, and protein synthesis. The results emphasize how constant dim light can mask the biological clock of Acropora digitifera.
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| 41.
学位論文（リポジトリ） |
学位
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Nagata, Masashi ; 永田, 仁
概要:
Background: Our previous report described how postoperative progression of sarcopenia predicted longterm prognosis after
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complete resection of non-small cell lung cancer (NSCLC) in heavy smokers. However, there are currently no effective means to treat progressive sarcopenia. In this study, we aimed to confirm our previous findings in a larger population and to identify factors associated with postoperative progression of sarcopenia to propose possible preventative measures.Methods: This retrospective study analyzed the data of 1,095 patients who underwent curative lobar resection for NSCLC at Kanagawa Cancer Center. We divided patients into four groups according to sex and Brinkman index (BI) above or below 600. Six-month postoperative changes in the skeletal muscle index (SMI) were calculated and associations between clinicopathological factors including changes in SMI and mortality from postoperative 6 months were examined. Only in groups in which postoperative depletion of SMI was shown to be associated with the prognosis, we identified clinicopathological factors associated with depletive SMI.Results: The overall survival rates of 1,095 patients were 89.8% and 82.5% at 3 and 5 years, respectively. The median 6-month change in SMI was –3.4% (range, −22.3% to +17.9%). Multivariate analysis revealed that poor prognosis was independently predicted by a large reduction in the SMI (cut-off value: −10%) in males with a BI ≥600. In 391 heavy-smoking males, factors associated with a postoperative change in SMI ≤−10% were history of other cancers (including gastric cancer) low forced expiratory volume in one second (FEV 1.0, cut-off value: 1,870 mL), and prolonged operation time (cut-off value: 200 minutes).Conclusions: Perioperative measures to prevent postoperative sarcopenia are appropriate for heavy smokers. We obtained some clues regarding countermeasures, one of which may be avoiding long-time operation. Further studies including clinical trials to assess perioperative anti-sarcopenia treatments, are needed.
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| 42.
論文（リポジトリ） |
論文（リポジトリ）
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Naito, Tadasuke ; Ushirogawa, Hiroshi ; Fukushima, Takuya ; Tanaka, Yuetsu ; Saito, Mineki
概要:
Background: EOS plays an important role in maintaining the suppressive function of regulatory T cells (Tregs), and induc
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es a regulated transformation of Tregs into T helper-like cells, which are capable of secreting proinflammatory cytokines in response to specific inflammatory signals. Meanwhile, significant reduction in Treg activity along with production of proinflammatory cytokines has been reported in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP).\nMethods: In this study, to examine whether there is an alteration in EOS expression in peripheral blood mononuclear cells (PBMCs) derived from HTLV-1-infected individuals especially HAM/TSP, we investigated the expression of HTLV-1 tax genotype, proviral load (PVL), and the mRNA expression of tax, HBZ and EOS in HTLV-1 infected individuals including adult T-cell leukemia/lymphoma (ATL), HAM/TSP, or asymptomatic carriers. The expression levels of EOS mRNA and protein in various HTLV-1-infected or uninfected human T-cell lines were also investigated.\nResults: EOS was highly expressed at the protein level in most HTLV-1 infected T-cell lines, and was augmented after the HTLV-1 regulatory factor Tax was induced in a Tax-inducible JPX-9 cell line. Immunoprecipitation experiments demonstrated a physical interaction between EOS and the viral regulatory protein Tax, but not HBZ. Meanwhile, there was a significant decrease in EOS mRNA levels in PBMCs of HTLV-1 infected individuals irrespective of their clinical statuses. We found an inverse correlation between EOS mRNA levels and HTLV-1 PVL in ATL patients, and positive correlations between both EOS mRNA load and PVL, and EOS and HBZ mRNA load in HAM/TSP patients, whereas this correlation was not observed in other clinical statuses.\nConclusions: These findings suggest that both Tax and HBZ can alter the expression of EOS through undetermined mechanisms, and dysregulated expression of EOS in PBMCs of HTLV-1 infected individuals may contribute to the pathological progression of HTLV-1-associated diseases, such as ATL and HAM/TSP.
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| 43.
論文（リポジトリ） |
論文（リポジトリ）
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西山, 桂一 ; 島田, 拓 ; 吉田, 譲 ; 田村, 常雄 ; Nishiyama, Keiichi ; Shimada, Taku ; Yoshida, Yuzuru ; Tamura, Hisao
概要:
The harvestman species, Parabeloniscus caudatus Suzuki, 1973 (Opiliones, Epedanidae), has been recorded from Okinawa-jim
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a Island, Miyagi-jima Island and Ikei-jima Island of the central Ryukyus, Japan. This species is considered to be highly dependent on cave environments (Shimojana 1978; 1979). Our survey found new habitats of P. caudatus from Amami-oshima, Tokunoshima and Okinawa-jima islands in the central Ryukyus, Japan. An unidentified Parabeloniscus species has previously been reported from Amami-oshima and Tokunoshima islands, and our study confirmed for the first time that P. caudatus is distributed on these islands. We also found the species under stones in the forests outside caves. A previous study reported the presence of eyeless individuals (Shimojana 1979). The current study also found eyeless individuals from two separate caves.
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| 44.
論文（リポジトリ） |
論文（リポジトリ）
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佐藤, 大義 ; Sato, Taigi
概要:
沖縄島の羽地内海からシマノハテマゴコロガイPeregrinamor gastrochaenans Kato & Itani, 2000を採集した.本種はミナミアナジャコUpogebia carinicauda (Stimpson, 1860
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) の頭胸甲腹面に付着して生活するチリハギ科の二枚貝であり,宿主が熱帯から亜熱帯にかけて広く分布するのに対して本種は模式産地である奄美大島のみでしか見出されていない極めて分布の狭い種として知られていた.今回,沖縄島から採集されたことによって本種の分布は沖縄島まで拡大したが,沖縄島における生息状況はよく分っておらず状況把握に向けた今後の研究が望まれる.
Peregrinamor gastrochaenans Kato & Itani, 2000, a symbiotic bivalve with Upogebia carinicauda (Stimpson, 1860), is recorded from Haneji Inland Sea, Okinawa Island, Japan. This represents the first record from Okinawa Island and the second record of the species after one from Amami-Ohshima Island. The distributional range of the species is expanded to the south. 論文 続きを見る |
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| 45.
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前之園, 唯史 ; Maenosono, Tadafumi
概要:
沖縄諸島の沿岸域からツェンナーガニ属(新称) Zehntneriana Ng & Takeda, 2010の3種[アシナガツェンナーガニ(改称)Z. miyakei (Takeda, 1972),オガサワラツェンナーガニZ. novaein
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sulicola (Takeda & Kurata, 1977),ビロードツェンナーガニZ. tadafumii Lee, Kim & Ng, 2015]の標本を採集した.これら3種のうち,アシナガツェンナーガニは沖縄島からの初記録であり,オガサワラツェンナーガニは琉球列島から初記録である.本稿ではこれら3種に加えて,琉球列島からの採集記録もあるアマクサツェンナーガニZ.amakusae (Takeda & Miyake, 1969)を含めた計4種について,分布記録,生息環境およびこれまでに提唱された和名についての情報を整理した.さらに, Z. serrata Ng & Lin, 2015も加えた日本･台湾産のツェンナーガニ属5種の検索表も与えた.
Three species of the pilumnid genus, Zehntneriana Ng & Takeda, 2010, viz. Z. miyakei (Takeda, 1972), Z. novaeinsulicola (Takeda & Kurata, 1977), Z. tadafumii Lee, Kim & Ng, 2015, were collected from the Okinawa Island Group, central Ryukyus, Japan. Zehntneriana miyakei and Z. novaeinsulicola are recorded for the first time from Okinawa Island and the Ryukyu Islands, respectively. Distributional records, habitats and standard Japanese names of the above three species and Z. amakusae (Takeda & Miyake, 1969) are summarized. An identification key to the five species of Zehntneriana in the Japan and Taiwan is also provided. 論文 続きを見る |
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| 46.
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Yamagishi, Makoto ; Hori, Makoto ; Fujikawa, Dai ; Ohsugi, Takeo ; Honma, Daisuke ; Adachi, Nobuaki ; Katano, Harutaka ; Hishima, Tsunekazu ; Kobayashi, Seiichiro ; Nakano, Kazumi ; Nakashima, Makoto ; Iwanaga, Masako ; Utsunomiya, Atae ; Tanaka, Yuetsu ; Okada, Seiji ; Tsukasaki, Kunihiro ; Tobinai, Kensei ; Araki, Kazushi ; Watanabe, Toshiki ; Uchimaru, Kaoru
概要:
Although global H3K27me3 reprogramming is a hallmark of cancer, no effective therapeutic strategy for H3K27me3-high mali
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gnancies harboring EZH2(WT/WT) has yet been established. We explore epigenome and transcriptome in EZH2(WT/WT) and EZH2(WT/Mu) aggressive lymphomas and show that mutual interference and compensatory function of co-expressed EZH1 and EZH2 rearrange their own genome-wide distribution, thereby establishing restricted chromatin and gene expression signatures. Direct comparison of leading compounds introduces potency and a mechanism of action of the EZH1/2 dual inhibitor (valemetostat). The synthetic lethality is observed in all lymphoma models and primary adult T cell leukemia-lymphoma (ATL) cells. Opposing actions of EZH1/2-polycomb and SWI/SNF complexes are required for facultative heterochromatin formation. Inactivation of chromatin-associated genes (ARID1A, SMARCA4/BRG1, SMARCB1/SNF5, KDM6A/UTX, BAP1, KMT2D/MLL2) and oncovirus infection (HTLV-1, EBV) trigger EZH1/2 perturbation and H3K27me3 deposition. Our study provides the mechanism-based rationale for chemical dual targeting of EZH1/2 in cancer epigenome.
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| 47.
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呉屋, 英樹 ; Goya, Hideki
概要:
According to the new Course of Study (2017, 2018) in Japan, promoting learners’ autonomous learning through Active Learn
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ing in English lessons has been gaining much attention these days. In general, pair-work or group-work application in a classroom setting is frequently utilized in actual English language teaching practices, and deeper learning outcome is expected to happen as a result of such collaborative activities. However, a simple employment of such teaching framework does not guarantee pedagogical benefits as much as expected. The present study aimed to construe how English teachers serving at public high schools perceived a principle of active learning. More specifically, the study surveyed 53 in-service English teachers to clarify how they interpreted the principle of deep learning stated in the new Course of Study, how they reflected the principle in their actual practices, what concerns they had when converting the principle into the form of teaching practices. The results gained from KH Coder indicated that despite much concern about the autonomous as well as interactive behavior of high school students, the teachers’ responses showed a lack of clear interpretation of deep leaning. With the finding in mind, the study discusses a necessity of awareness-raising activities so that ALBT can further develop theoretically and pedagogically in an EFL context.
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| 48.
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東矢, 光代 ; 當間, 千夏 ; Toya, Mitsuyo ; Toma, Chinatsu
概要:
This paper reports the results of Beliefs, Events and Values Inventory (BEVI) analyses for two groups of students at the
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University of the Ryukyus: those who began a course in a newly established minor, the Global Shinryo Program, and those who were studying Media English as part of their required coursework. The analyses produced three graphs generated by the BEVI administration system: an aggregate profile, a decile profile, and a profile contrast. The results revealed that both groups shared similar patterns: high in Self Awareness (Scale 11), Sociocultural Openness (Scale 15), and Global Resonance (Scale17). Both groups tended to be liberal in Religious and Gender Traditionalisms (Scales 13and 14). These altogether indicate that students in both groups are highly competent in dealing with cross-cultural experiences and carrying out intercultural collaboration. Conversely, the scales oriented toward inner self and core values, such as Scales 7 and 8, highlighted a difference existing in Scale 8 (Socioemotional Convergence). Their decile profiles and profile contrasts illustrated that there exists a considerable degree of variance within the same group of students. Understanding this variance and devising ways to support those who are unready for global experiences will be a critical task of instructors and administrators.
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| 49.
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鈴木, 正士 ; Suzuki, Masashi
概要:
En el episodio, Marcela aparece descrita como una mujer discreta y recatada. Sin embargo, en el cap. XII, Pedro, un cabr
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ero, dice sobre ella: “aquella endiablada moza de Marcela.” En el mundo cristiano el término “diablo” es una palabra radical. Además, en el cap. XIII, Ambrosio, un amigo de Grisóstomo, califica a Marcela de “enemiga mortal del linaje humano.” La razón por la que le dirigen a Marcela estas palabras tan severas, se debe a que Miguel de Cervantes Saavedra (1547-1616) la critica fuertemente. Cervantes, que alberga sus dudas hacia la devoción excesiva, critica veladamente a Marcela, quien desea de todo corazón el matrimonio con Dios, es decir la unión con Dios, y rechaza el matrimonio con los hombres. Para ello, describe a Grisóstomo como enamorado de Marcela y, al ser rechazado por ella, acaba suicidándose. Cervantes fue claramente influido por el pensamiento humanista de Desiderio Erasmo (1467?-1536). En el ideario humanista de Erasmo se valora mucho el matrimonio humano. En el texto de Don Quijote no aparece concretamente cómo murió Grisóstomo, pero se da a entender que se suicidó. Si así fuera, tendría que ir al infierno porque cometió un pecado mortal, el suicidio. En resumen, irónicamente Marcela se ha convertido en el diablo que hizo caer a Grisóstomo, humano, en el infierno, porque ella anhela el matrimonio con Dios y rechaza la petición de matrimonio de Grisóstomo. En el episodio del funeral de Grisóstomo, Cervantes critica la devoción fanática e intolerancia religiosa en la España del siglo XVII, a través de Marcela y Grisóstomo, que acaba muerto por la exagerada devoción religiosa de ella.
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| 50.
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Keith, Barry ; Murray, Adam
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