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山崎亮一著
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浦上家史編纂委員会
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二宮周平編集代表
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論文（リポジトリ） |
論文（リポジトリ）
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M. M. Emam Ahmed, ; M. Ashik Iqbal Khan ; Md. Shahjahan Kabir ; Fukuta, Yoshimichi ; Obara, Mitsuhiro
概要:
Genetic variations in the root traits of rice remain unexplored in relation to varietal groups and diverse ecosystems. Therefore, we evaluated 257 Bangladeshi accessions, which included landraces and improved varieties belonging to four
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ecotypes (Aus, Aman, Boro and Jhum), to understand genetic variations in the total root length (TRL), maximum root length and root number under different concentrations of ammonium and nitrate nitrogen in hydroponic culture. There were large variations in all traits across all nitrogen levels. Active elongation of individual roots of the landrace type across all nitrogen conditions suggested a higher potential for the uptake of nutrients by extending roots distribution in any nitrogen environment, while the active development of primary root primordia in the improved type in the presence of nitrate suggested a higher potential for the uptake of nitrate from the soil surface by extending roots distribution around soil surface. Cluster analysis classified the examined accessions into two groups according to their TRL: cluster I with a longer TRL and cluster II with a shorter TRL across all nitrogen conditions. Each of these groups was further divided into two subclusters: sub-cluster Ia, in which the longer TRL resulted from active development of primary root primordia, sub-cluster Ib, in which the longer TRL resulted from active elongation of individual roots, subcluster IIa, in which the shorter TRL resulted from severe reduction of the elongation of individual roots, and sub-cluster IIb, in which the shorter TRL resulted from a moderate reduction in the elongation of individual roots. Further investigation revealed a difference in the composition of these four sub-clusters among the four ecotypes, indicating that Aman was the most diverse ecotype, followed by Aus. The root traits of these promising accessions could be exploited in the future to understand genetic and physiological mechanism(s) of adaptation to diverse ecosystems.
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Nakamura, Hideta ; Miyagi, Kazuya ; Otsuki, Mariko ; Higure, Yuuri ; Nishiyama, Naoya ; Kinjo, Takeshi ; Nakamatsu, Masashi ; Haranaga, Shusaku ; Tateyama, Masao ; Fujita, Jiro
概要:
Treatment with tocilizumab (TCZ) to block interleukin-6 (IL-6) signalling is predicted to mitigate cytokine release synd
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rome (CRS) caused by coronavirus disease 2019 (COVID-19). However, the adverse effects of TCZ on patients with COVID-19 remain unclear. We herein report a patient with COVID-19 treated with TCZ who developed acute hypertriglyceridaemia. Despite favipiravir treatment, acute respiratory distress syndrome developed in a 45-year-old patient with COVID-19; thus, TCZ was initiated. The triglyceride levels greatly increased after TCZ administration. Physicians should consider the negative impact of TCZ on the lipid profile in patients with COVID-19, although COVID-19-induced CRS itself may be an aggravating factor.
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Saleh, Ayat Ali ; Senjyu, Tomonobu ; Alkhalaf, Salem ; Alotaibi, Majed A. ; Hemeida, Ashraf M.
概要:
This work introduces multi-objective water cycle algorithm (MOWCA) to find the accurate location and size of distributed
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energy resource (DERs) considering different load models for two seasons (winter, and summer). The impact of uncertainties produced from load and renewable energy resource (RES) such as wind turbine (WT) and photovoltaic (PV) on the performance of the radial distribution system (RDS) are covered as this is closer to the real operation condition. The point estimate method (PEM) is applied for modeling the RES uncertainties. An optimization technique is implemented to find the multi-objective optimal allocation of RESs in RDSs considering uncertainty effect. The main objectives of the work are to maximize the technical, economic and environmental benefits by minimizing different objective functions such as the dissipated power, the voltage deviation, DG cost and total emissions. The proposed multi-objective model is solved by using multi-objective water cycle algorithm (MOWCA), considering the Pareto criterion with nonlinear sorting based on fuzzy mechanism. The proposed algorithm is carried out on different IEEE power systems with various cases.
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Miyagi, Yoshihiro ; Kinjo, Tatsuya ; Yoshizumi, Tomoharu ; Harada, Noboru ; Arakaki, Shingo ; Kinjo, Tetsu ; Hokama, Akira ; Takatsuki, Mitsuhisa
概要:
Background: Primary sclerosing cholangitis (PSC) is a well-known complication of ulcerative colitis (UC), but it is rare
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to encounter patients requiring both living donor liver transplantation (LDLT) and proctocolectomy. We report a case of elective two-stage surgery involving proctocolectomy performed after LDLT for a patient with early colon cancer concurrent with PSC-related UC. To our knowledge, this is the first report of concurrent cancer successfully treated with both LDLT and proctocolectomy. Case presentation: A 32-year-old Japanese man with colon cancer associated with UC underwent restorative proctocolectomy at 3 months after living donor liver transplantation (LDLT) for PSC. He was diagnosed with PSC and UC when he was a teenager. Conservative therapy was initiated to treat both PSC and UC. He had experienced recurrent cholangitis for years; therefore, a biliary stent was placed endoscopically. However, his liver function progressively deteriorated. Colonoscopic surveillance revealed early colon cancer; hence, surgical treatment was considered. PSC progressed to cirrhosis and portal hypertension; hence, LDLT was performed before restorative proctocolectomy. Three months after LDLT, we performed restorative proctocolectomy with ileal pouch–anal anastomosis. The postoperative course was uneventful. The patient was well, with good liver and bowel functions and without tumor recurrence, more than 1 year after proctocolectomy. Conclusions: With strict patient selection and careful patient management and follow-up, elective proctocolectomy may be performed safely and effectively after LDLT for concurrent early colon cancer with PSC-related UC. There are no previous reports of the use of both LDLT and proctocolectomy for the successful treatment of PSC-related UC and concurrent cancer.
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| 11.
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Ihara, Kensuke ; Sasano, Tetsuo ; Hiraoka, Yuichi ; Togo-Ohno, Marina ; Soejima, Yurie ; Sawabe, Motoji ; Tsuchiya, Megumi ; Ogawa, Hidesato ; Furukawa, Tetsushi ; Kuroyanagi, Hidehito
概要:
Dilated cardiomyopathy (DCM) is a fatal heart disease characterized by left ventricular dilatation and cardiac dysfuncti
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on. Recent genetic studies on DCM have identified causative mutations in over 60 genes, including RBM20, which encodes a regulator of heart-specific splicing. DCM patients with RBM20 mutations have been reported to present with more severe cardiac phenotypes, including impaired cardiac function, atrial fibrillation (AF), and ventricular arrhythmias leading to sudden cardiac death, compared to those with mutations in the other genes. An RSRSP stretch of RBM20, a hotspot of missense mutations found in patients with idiopathic DCM, functions as a crucial part of its nuclear localization signals. However, the relationship between mutations in the RSRSP stretch and cardiac phenotypes has never been assessed in an animal model. Here, we show that Rbm20 mutant mice harboring a missense mutation S637A in the RSRSP stretch, mimicking that in a DCM patient, demonstrated severe cardiac dysfunction and spontaneous AF and ventricular arrhythmias mimicking the clinical state in patients. In contrast, Rbm20 mutant mice with frame-shifting deletion demonstrated less severe phenotypes, although loss of RBM20-dependent alternative splicing was indistinguishable. RBM20^
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Nakamura, Hideta ; Tateyama, Masao ; Tasato, Daisuke ; Haranaga, Shusaku ; Higa, Futoshi ; Matsuzaki, Akiko ; Yoshimi, Naoki ; Fujita, Jiro
概要:
Asymptomatic pulmonary sarcoidosis can develop after starting antiretroviral therapy. The decision on whether to treat sarcoidosis with corticosteroids should be based on the disease severity.
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| 13.
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Akamine, Kozue ; Mekaru, Keiko ; Gibo, Keiya ; Nagata, Chinatsu ; Nakamura, Rie ; Oishi, Sugiko ; Miyagi, Maho ; Heshiki, Chiaki ; Aoki, Yoichi
概要:
Purpose: To investigate impact of the one‐carbon metabolism (OCM) on oocyte maturity and embryo development.\nMethods: T
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his prospective study analyzed 18 women who agreed to participate. We measured the OCM biomarkers’ concentrations including Vitamin B12 (VB12), folic acid (FA), and homocysteine (Hcy) in serum and follicular fluid (FF), and assessed their correlation. We also evaluated the influence of such OCM biomarker concentrations in mono‐FF on oocyte maturation, fertilization, embryo quality, and consequent pregnancy after embryo transfers.\nResults: All biomarkers showed a high concentration variability in different follicles of each woman, but their mean levels correlated with the serum levels. Among the 106 collected oocytes, 92 were mature, 59 were fertilized, and 16 yielded good‐quality embryos. We performed 26 single embryo transfers, and 7 patients achieved clinical pregnancies. VB12 concentration (FF) was significantly lower in fertilized than unfertilized oocytes by univariate analysis. In multivariate logistic analysis, a significant correlation was found between FA concentration (FF) <14.25 ng/mL and good‐quality embryos and between Hcy concentration (FF) <4.9 nmol/mL and clinical pregnancy.\nConclusion: OCM in FF may affect fertilization, embryo quality, and clinical pregnancy.
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| 14.
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Nakagawa, Tessui ; Uesato, Hiroki ; Burrell, Anthony K. ; Ichikawa, Takayuki ; Miyaoka, Hiroki ; Davis, Benjamin L. ; Kojima, Yoshitsugu
概要:
“One-pot regeneration”, which is simple regneneration method of ammonia borane (AB) using hydrazine and liquid ammonia,
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enables conversion of AB from hexagonal boron nitride (h-BN) after milling hydrogenation. Solution ^<11>B-NMR revealed the presence of AB after NH_3/N_2H_4 treatment of milled h-BN (BNH_x) although the yield of AB was less than 5%. The conversion mechanism was clarified as B-H bonds on the h-BN surface created by ball-milling under hydrogen pressure have an ability to form AB, which was confirmed by Thermogravimetry-Residual Gas Analysis (TG-RGA) and Infrared (IR) analysis. The reaction routes are also the same as regeneration route of polyborazylene because intermediates of AB such as (B(NH_2)_3 and hydrazine borane were found by solution ^<11>B-NMR after soaking BNH_x in liquid NH_3 and hydrazine, respectively. Because of the fact that all reactions proceed on the h-BN surface and no reaction proceeds when neat h-BN is treated, breaking of B_3N_3 ring structure and then creation of B-H bond is the key issue to increase conversion yield of AB.
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大島, 千幸 ; 林, 幸希 ; 寺井, 純汰 ; 工藤, 翔里 ; Oshima, Kazuyuki ; Hayashi, Koki ; Terai, Junta ; Kudo, Shori
概要:
This study records six Mantodea species from several islands in the Miyako Islands, including first records from some is
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lands. Of the six Mantodea species, four species, i.e. Statilia nemoralis (Saussure, 1870), Tenodera fasciata (Olivier, 1792), T. angustipennis Saussure, 1869 and Hierodula patellifera (Audinet-Serville, 1839), are newly recorded from some adjacent islands of Miyako-jima Island, and two species, i.e. Mantis religiosa (Linnaeus, 1758) and Amantis nawai (Shiraki, 1908), were collected from previously recorded islands in the Miyako Is. Mantis religiosa and T. fasciata were primarily observed in open grasslands, and in contrast, T. angustipennis was mainly found around forest edges on Tarama-jima I. Few nymphs and an ootheca of S. nemoralis were found in grasslands on Ikema-jima I. and Kurima-jima I. Hierodula patellifera was the most abundant among mantis species during these surveys; a number of adults and a few nymphs of this species were observed in our expedition. For Amantis nawai, specimens of only the adult stage were observed, on the dried leaf litter of the forest floor on Miyako-jima I. In addition, three Mantodea species, M. religiosa, T. angustipennis and H. patellifera, were collected from UV-LED light trap set as a counterplan against Anomala albopilosa (Hope, 1839) (Coleoptera: Scarabaeidae) on Tarama-jima I.
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Yamasako, Junsuke ; Kuroda, Keita ; 山迫, 淳介 ; 黒田, 圭太
概要:
Cophinopoda chinensis (Fabricius, 1794) is newly recorded from the Miyako Islands, the Ryukyus, Japan, with DNA barcode
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data.
東南アジアに広く分布するアオメアブCophinopoda chinensisを池間島,伊良部島,宮古島,来間島にて採集された標本に基づいて宮古諸島より初めて記録し,来間島の１個体より得たDNAバーコード配列の登録情報を記した. 論文 続きを見る |
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石田, 憲 ; Ishida, Akira
概要:
Two sesarmid crab species, Circulium scandens (Ng & Liu, 2003), and Chiromantes ryukyuanum Naruse & Ng, 2008, are newly recorded from Kohama-jima Island, Ryukyu Archipelago, southwestern Japan.
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Okuno, Junji ; Naruse, Tohru ; 奥野, 淳兒 ; 成瀬, 貫
概要:
A bizarre crab of the family Leucosiidae, Oreotlos pala Tan & Ng, 1996 is redescribed on the basis of four specimens, in
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cluding three males and one female, collected from the Ryukyu Islands. This species was known only by the female holotype from Guam, the Mariana Islands. Our material from the Ryukyus enable us to describe the morphology of taxonomically important male characters (abdomen, telson, and gonopods) of this poorly known species for the first time. The assignment of the species to Oreotlos is fully confirmed.
久米島および宮古群島の伊良部島より採集された4個体の標本に基づき,コブシガニ科ツノカルイシコブシ属Oreotlos Ihle, 1918 のOreotlos pala Tan & Ng, 1996を再記載した.本種は,マリアナ諸島グアム島で採集された雌1個体に基づいて記載され,その後,川本・奥野(2003)による一般向けのガイドブックに久米島で撮影された個体の水中写真が掲載されているにすぎない稀種であった.本種の雄の形態はこれまで知られておらず,またホロタイプは鉗脚と歩脚を欠いているが,本研究の検討標本は原記載にも示されている頭胸甲背面の肝域後方,側方突出部,鰓域後方にそれぞれ1個大きく深いくぼみを有することにより,同種であると判断した.本種には標準和名が与えられていなかったため,頭胸甲背面に月面のクレーターを彷佛させる顕著なくぼみを有することから,ゲツメンカルイシコブシの新称を提唱する. 論文 続きを見る |
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Yamasaki, Hideo
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Salatkiewicz, Michal Mateusz
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Yoneda, Susumu ; 米田, 晋
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Millman, Jasmine
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Okitsu, Shiho ; 澳津, 志帆
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学位論文
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Sinzato, Hotaka ; Zamami, Yu ; Kondo, Tsuyoshi
概要:
For simultaneous screening of mixed features (MF) by DSM-5 and mixed depression (MD) by Benazzi, useful symptoms were ex
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tracted from our 12-item dimensional scale for depressive mixed state (DMX-12). Subjects were 190 consecutive cases with major depressive episode (MDE) who visited our clinic. Associations between symptomatological combinations of the DMX-12 and MF or MD were analyzed using receiver operating characteristic (ROC). The rate of MF was 4.2% while that of MD was 22.6%. Eight symptoms (overreactivity, inner tension, racing/crowded thought, impulsivity, irritability, aggression, risk-taking behavior, and dysphoria) with their AUC > 0.6 for ROC curves were specially focused on distinguishing patients with MF or MD from non-mixed patients. By using these 8 symptoms, 40.5% of the overall patients were screened as positive at the same cut-off value (≥13) for both MD and MF. The AUC of ROC curve and sensitivity/specificity were well balanced together with sufficient negative predictive values. The abovementioned 8 symptoms seem to be helpful for primary screening and negative check of DMX with considerable severity during MDE.
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| 25.
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齋藤, 将人 ; Saito, Masato
概要:
筆者らは，これまで，Single-Input Multiple-Output (SIMO) や Multiple-Input Multiple-Output (MIMO)および大規模MIMOにおける受信アンテナのハードウェアコスト削減法とし
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てアンテナパターン多重 (Antenna Pattern Multiplexing; APM) 技術に着目して研究を行ってきた．本稿では，APMの原理について時変指向性利得として，周波数分割多重および符号分割多重に基づく周期波形を用いて説明を試み，単一のアンテナ系統から，複数の分離可能なアンテナ出力が得られることを示す．
We have been studied Antenna Pattern Multiplexing (APM) technique suitable for receivers of Single-Input Multiple-Output (SIMO), Multiple-Input Multiple-Output (MIMO), and massive MIMO systems. APM technique has potential to reduce the hardware cost of the receivers, for example, size of antenna, the number of required cables, cabling cost, calibration cost, maintenance cost, etc. In this paper, we try to explain the principle of APM with time-variable directional gain designed based on Frequency Division Multiplexing (FDM) and Code Division Multiplexing (CDM). Through the paper, we show how to obtain multiple distinguishable antenna outputs from a single Radio Frequency (RF) front-end. 論文 続きを見る |
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| 26.
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Iwamoto, Kensuke ; Chang, Chin-Wei ; Imai, Hideyuki
概要:
Studies have suggested that fishes with broad distribution ranges, long pelagic duration, and great mobility in their ea
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rly life histories may have an advantage in their ability to return to their natal reef habitats. Siganus spinus is a siganid fish with a broad dispersal strategy, which may also exploit its great mobility to enhance self-recruitment. Variations in mitochondrial DNA sequences were analysed to estimate the genetic structure and demographic history of Siganus spinus in the West Pacific. In total, 446 nucleotide sequences, including the tRNAThr gene, the tRNAPro gene, and the first half of the control region, were analysed from 240 individuals sampled at five sites spanning the West Pacific Ocean; 37 haplotypes were identified. Our results showed significant geographic genetic structure as well as isolation by distance. Both neutrality tests and mismatch distribution indicated that the population expansion of S. spinus through the study area may have occurred in the late Quaternary. A dispersal strategy characterised by large juveniles and open-sea distribution may have contributed to a sudden population expansion after the last glacial period, along with an expansion of distribution.
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Li, Yilin ; 李, 益玲
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Adrianus, Bannepading
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Adewuyi, Oludamilare Bode
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Koswatta, Anupa
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Mizuyama, Masaru ; 水山, 克
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相澤, 正隆
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Biondi, Piera
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Angka, Mahardini
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太田, 格
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Selma, Bouchekioua
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| 37.
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Okuyama, Momoko ; 奥山, 桃子
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| 38.
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Okuma, R. ; Ueta, D. ; Kuniyoshi, S. ; Fujisawa, Y. ; Smith, B. ; Hsu, C. H. ; Inagaki, Y. ; Si, W. ; Kawae, T. ; Lin, H. ; Chuang, F. C. ; Masuda, T. ; Kobayashi, R. ; Okada, Y.
概要:
CeTe_3 is a unique platform to investigate the itinerant magnetism in a van der Waals (vdW) coupled metal. Despite chemi
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cal pressure being a promising route to boost quantum fluctuation in this system, a systematic study on the chemical pressure effect on Ce^<3+>(4f^1) states is absent. Here, we report on the successful growth of a series of Se doped single crystals of CeTe_3. We found a fluctuation driven exotic magnetic rotation from the usual easy-axis ordering to an unusual hard-axis ordering. Unlike in localized magnetic systems, near-critical magnetism can increase itinerancy hand-in-hand with enhancing fluctuation of magnetism. Thus, seemingly unstable hard-axis ordering emerges through kinetic energy gain, with the self-consistent observation of enhanced magnetic fluctuation (disorder). As far as we recognize, this order-by-disorder process in fermionic system is observed for the first time within vdW materials. Our finding opens a unique experimental platform for direct visualization of the rich quasiparticle Fermi surface deformation associated with the Fermionic order-by-disorder process. Also, the search for emergent exotic phases by further tuning of quantum fluctuation is suggested as a promising future challenge.
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| 39.
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Chen, Bixia
概要:
Urban trees are under unprecedented pressure and competition worldwide with other land uses. Homestead windbreaks in urb
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an areas are an important part of urban forests because of their proximity to settlements. To aid in the conservation of old-growth homestead trees in the urban setting on Ryukyu Archipelago, Japan, this article surveys the dimensions and spatial distribution of century-old trees planted as windbreaks along homestead borderlines on Ishigaki Island in the Ryukyu Archipelago and the historical change caused by urban sprawl. The homesteads studied in this article do not match the scale of a traditional Western context and usually consist of an area of less than 200 square meters on Okinawa. A combined approach consisting of field surveys and the study of aerial photos was applied to identify changes in spatial distribution of tree lines surrounding the houses in 1945, 1972 and the present. We measured the dimensions of 1659 Fukugi trees with a minimum diameter at breast height (DBH) of 5 cm. The mean tree height, mean DBH and mean estimated tree age were 7.3 m, 26.9 cm and 107.5 years, respectively. Homestead trees are not only useful as windbreaks, timber sources and musical instruments, but have also been historically resilient in the face of strong typhoons and catastrophic tsunamis in the region. Over 60% of the surveyed trees were planted on the east and north sides of homesteads as protection from typhoons and monsoonal winds in the winter. In addition to G. subelliptica, other tree species, namely Podocarpus macrophyllus and Diospyros egbert-walkeri, have been commonly used as homestead windbreaks. However, homestead windbreaks in highly urbanized regions are generally declining and have experienced fragmentation, lower tree density and shorter tree height than those in rural areas. Because of the small number of trees older than 200 years, we assume that high urbanization has jeopardized old-growth trees. The demand for settlement land dramatically increases as the population increases and household-size decreases, creating more households. Therefore, a conservation project involving multiple stakeholders must be developed to conserve old-growth trees in urban settings.
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| 40.
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Tomita, Asami ; Nashir, Uddin ; Obara, Mitsuhiro ; Saito, Hiroki ; Fukuta, Yoshimichi
概要:
Wide variations of typhoon-induced spikelet sterility and days to heading (DH) were found among 317 introgression lines (INLs) originating from new-plant-type varieties with a genetic background of Indica Group rice variety IR 64.
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Sterility was induced by continuous dry winds from the typhoon. The most seriously affected were 194 INLs with DH ranging from 83 to 86 days. Positive correlations with the spikelet sterility score (SSS) were found for culm length (CL), panicle length (PL), and panicle weight (PW). Based on these traits and DH, the 194 INLs were classified into three groups: A1, A2, and B. The means of SSS and four traits (CL, PL, culm and leaf weight (CW), and panicle weight (PW)) were the lowest in group A1, and highest in group B. PN was significantly higher in group B than those in the others. Seven quantitative trait loci (QTL) for SSS were detected on chromosomes (chr.) 1, 2, 4, 7 (two), 8, and 11. Among them, the QTL of chr. 4 was located in the same regions as those of DH, CL, PL, CW, and panicle number (PN). Thus, the region on chr.4 might induce sterility in the INLs by modifying plant architecture, such as large panicles or high plant height with the minor effect of many tillers. The relationships among traits, and the QTLs will be useful information for genetic improvement of tolerance to typhoon damage in rice.
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| 41.
論文（リポジトリ） |
論文（リポジトリ）
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Tokuyama, Takenobu ; Shy, Jhy-Yun ; Lin, Hui-Chen ; Henmi, Yasuhisa ; Mather, Peter ; Hughes, Jane ; Tsuchiya, Makoto ; Imai, Hideyuki
概要:
The fiddler crab, Austruca lactea inhabits tidal flat areas and is widely distributed across Japan, the Korean Peninsula
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, China, Taiwan and northern Vietnam. Fiddler crab habitat is being lost rapidly due to human impacts and this species is currently listed as endangered in Japan. We studied the population genetic structure of A. lactea using mitochondrial DNA control region markers to define management units. A. lactea individuals were sampled from Osaka, Hiroshima and Kumamoto in Japan, and from Taichung and the Penghu Islands in Taiwan. All local samples exhibited high levels of genetic diversity, and no sampled populations showed evidence for a significant decline in effective population size that can result from population bottleneck effects. Pairwise FST estimates distinguished three discrete A. lactea populations corresponding with, the Seto Inland Sea (Osaka and Hiroshima), Kyushu (Kumamoto) and Taiwan. The three populations showed clear differences in historical population expansion times and their population dynamics after expansion. Results of the study indicate that A. lactea dispersal is limited geographically and that high levels of genetic diversity are maintained both within and among populations.
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| 42.
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論文（リポジトリ）
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Iida, Hitoshi ; Iga, Junichi ; Hasegawa, Naomi ; Yasuda, Yuka ; Yamamoto, Tomoya ; Miura, Kenichiro ; Matsumoto, Junya ; Murata, Atsunobu ; Ogasawara, Kazuyoshi ; Yamada, Hisashi ; Hori, Hikaru ; Ichihashi, Kayo ; Hashimoto, Naoki ; Ohi, Kazutaka ; Yasui-Furukori, Norio ; Tsuboi, Takashi ; Nakamura, Toshinori ; Usami, Masahide ; Furihata, Ryuji ; Takaesu, Yoshikazu ; Iwamoto, Kunihiro ; Sugiyama, Nobuhiro ; Kishimoto, Taishiro ; Tsujino, Naohisa ; Yamada, Hiroki ; Hishimoto, Akitoyo ; Nemoto, Kiyotaka ; Atake, Kiyokazu ; Muraoka, Hiroyuki ; Katsumoto, Eiichi ; Oishi, Satoru ; Inagaki, Takahiko ; Ito, Fumiaki ; Imamura, Yayoi ; Kido, Mikio ; Nagasawa, Tatsuya ; Numata, Shusuke ; Ochi, Shinichiro ; Iwata, Masaaki ; Yamamori, Hidenaga ; Fujita, Junichi ; Onitsuka, Toshiaki ; Yamamura, Satoshi ; Makinodan, Manabu ; Fujimoto, Michiko ; Takayanagi, Yoichiro ; Takezawa, Kenji ; Komatsu, Hiroshi ; Fukumoto, Kentaro ; Tamai, Shinichiro ; Yamagata, Hirotaka ; Kubota, Chika ; Horai, Tadasu ; Inada, Ken ; Watanabe, Koichiro ; Kawasaki, Hiroaki ; Hashimoto, Ryota
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| 43.
論文（リポジトリ） |
論文（リポジトリ）
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尾方, 隆幸
概要:
論文
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| 44.
論文（リポジトリ） |
論文（リポジトリ）
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Matsushita, Madoka ; Muramoto, Akiko ; Nomura, Eri ; Eguchi, Yukari ; Kato, Ayako ; Sano, Yoshiko ; Kabayama, Mai ; Arakawa, Masashi ; Oguma, Yuko ; Yabe, Daisuke ; Matsunaga, Masaaki ; Yatsuya, Hiroshi ; Arima, Hiroshi ; Tsushita, Kazuyo
概要:
Background: The aim of this study was to determine the effectiveness of the Smart Life Stay (SLS) program, which is an e
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xperience-oriented stayover program, in combination with health tourism and mandatory health guidance on glucose metabolism after 2 years. Methods: The participants of the SLS program (n = 792) were recruited from a database of 23 medical insurers. They underwent a mandatory health examination termed Specific Health Checkups in 2014. The participants were included if they had diabetes or were at a high risk of diabetes and if they satisfied the following inclusion criteria: (1) body mass index (BMI; kg/m^2 ) > 25, or (2) waist circumference (WC; cm) > 85 for men and > 90 for women, or (3) hemoglobin A1c (HbA1c; %) > 5.6, or (4) fasting plasma glucose (FPG; mg/dl) > 100. Individuals who corresponded to one or more items were included as study participants. The control subjects (n = 3645) were nonparticipants of the program who were selected from the database and met the inclusion criteria. The lifestyle changes and changes in mean BMI, WC, FPG, and HbA1c in both groups from baseline to 2-year follow-up were compared by inverse probability weighting of a propensity score. Results: The percentage of people who exercised regularly increased significantly in the SLS group compared with the control group. In the SLS group, BW, BMI, and WC significantly decreased by 1.75 kg, 0.60 kg/m^2 , and 1.45 cm, respectively, whereas in the control group, WC, FPG, and HbA1c increased significantly by 0.38 cm, 3.37 mg/dl, and 0.12%, respectively. The comparison between groups revealed that the BW, BMI, WC, FPG, and HbA1c improved significantly in the SLS group. Conclusions: The SLS program is suggested to help improve glucose metabolism. This program could be a feasible option as a lifestyle intervention program for diabetes.
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| 45.
論文（リポジトリ） |
論文（リポジトリ）
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Shimada, Masaru ; Yamashita, Akio ; Saito, Manami ; Ichino, Motohide ; Kinjo, Takao ; Mizuki, Nobuhisa ; Klinman, Dennis M. ; Okuda, Kenji
概要:
Oncoprotein E6 of high-risk human papillomavirus (HPV) plays a critical role in inducing cell immortalization and malign
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ancy. E6 downregulates caspase-dependent pathway through the degradation of p53. However, the effect of HPV E6 on other pathways is still under investigation. In the present study, we found that HPV E6 directly binds to all three forms (precursor, mature, and apoptotic) of apoptosis-inducing factor (AIF) and co-localizes with apoptotic AIF. This binding induced MG132-sensitive reduction of AIF expression in the presence of E6 derived from HPV16 (16E6), a cancer-causing type of HPV. Conversely, E6 derived from a non-cancer-causing type of HPV, HPV6 (6E6), did not reduce the levels of AIF despite its interaction with AIF. Flow cytometric analysis revealed that 16E6, but not 6E6, suppressed apoptotic AIF-induced chromatin degradation (an indicator of caspase-independent apoptosis) and staurosporine (STS, a protein kinase inhibitor)-induced apoptosis. AIF knockdown reduced STS-induced apoptosis in both of 16E6-expressing and 6E6-expressing cells; however, the reduction in 16E6-expressing cells was lower than that in 6E6-expressing cells. These findings indicate that 16E6, but not 6E6, blocks AIF-mediated apoptosis, and that AIF may represent a novel therapeutic target for HPV-induced cervical cancer.
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| 46.
論文（リポジトリ） |
論文（リポジトリ）
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Gakuhari, Takashi ; Nakagome, Shigeki ; Rasmussen, Simon ; Allentoft, Morten E. ; Sato, Takehiro ; Korneliussen, Thorfinn ; Chuinneagain, Blanaid Ni ; Matsumae, Hiromi ; Koganebuchi, Kae ; Schmidt, Ryan ; Mizushima, Souichiro ; Kondo, Osamu ; Shigehara, Nobuo ; Yoneda, Minoru ; Kimura, Ryosuke ; Ishida, Hajime ; Masuyama, Tadayuki ; Yamada, Yasuhiro ; Tajima, Atsushi ; Shibata, Hiroki ; Toyoda, Atsushi ; Tsurumoto, Toshiyuki ; Wakebe, Tetsuaki ; Shitara, Hiromi ; Hanihara, Tsunehiko ; Willerslev, Eske ; Sikora, Martin ; Oota, Hiroki
概要:
Anatomically modern humans reached East Asia more than 40,000 years ago. However, key questions still remain unanswered
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with regard to the route(s) and the number of wave(s) in the dispersal into East Eurasia. Ancient genomes at the edge of the region may elucidate a more detailed picture of the peopling of East Eurasia. Here, we analyze the whole-genome sequence of a 2,500-year-old individual (IK002) from the main-island of Japan that is characterized with a typical Jomon culture. The phylogenetic analyses support multiple waves of migration, with IK002 forming a basal lineage to the East and Northeast Asian genomes examined, likely representing some of the earliest-wave migrants who went north from Southeast Asia to East Asia. Furthermore, IK002 shows strong genetic affinity with the indigenous Taiwan aborigines, which may support a coastal route of the Jomon-ancestry migration. This study highlights the power of ancient genomics to provide new insights into the complex history of human migration into East Eurasia.
論文 続きを見る |
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| 47.
論文（リポジトリ） |
論文（リポジトリ）
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Gakuhari, Takashi ; Nakagome, Shigeki ; Rasmussen, Simon ; Allentoft, Morten E. ; Sato, Takehiro ; Korneliussen, Thorfinn ; Chuinneagain, Blanaid Ni ; Matsumae, Hiromi ; Koganebuchi, Kae ; Schmidt, Ryan ; Mizushima, Souichiro ; Kondo, Osamu ; Shigehara, Nobuo ; Yoneda, Minoru ; Kimura, Ryosuke ; Ishida, Hajime ; Masuyama, Tadayuki ; Yamada, Yasuhiro ; Tajima, Atsushi ; Shibata, Hiroki ; Toyoda, Atsushi ; Tsurumoto, Toshiyuki ; Wakebe, Tetsuaki ; Shitara, Hiromi ; Hanihara, Tsunehiko ; Willerslev, Eske ; Sikora, Martin ; Oota, Hiroki
概要:
Anatomically modern humans reached East Asia more than 40,000 years ago. However, key questions still remain unanswered
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with regard to the route(s) and the number of wave(s) in the dispersal into East Eurasia. Ancient genomes at the edge of the region may elucidate a more detailed picture of the peopling of East Eurasia. Here, we analyze the whole-genome sequence of a 2,500-year-old individual (IK002) from the main-island of Japan that is characterized with a typical Jomon culture. The phylogenetic analyses support multiple waves of migration, with IK002 forming a basal lineage to the East and Northeast Asian genomes examined, likely representing some of the earliest-wave migrants who went north from Southeast Asia to East Asia. Furthermore, IK002 shows strong genetic affinity with the indigenous Taiwan aborigines, which may support a coastal route of the Jomon-ancestry migration. This study highlights the power of ancient genomics to provide new insights into the complex history of human migration into East Eurasia.
論文 続きを見る |
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| 48.
論文（リポジトリ） |
論文（リポジトリ）
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山脇, 拓実 ; Yamawaki, Takumi ; 大河内, 博 ; Okochi, Hiroshi ; 山本, 修司 ; Yamamoto, Shuji ; 山之越, 恵理 ; Yamanokoshi, Eri ; 島田, 幸治郎 ; Shimada, Kojiro ; 緒方, 裕子 ; Ogata, Hiroko ; 勝見, 尚也 ; Katsumi, Naoya ; 皆巳, 幸也 ; Minami, Yukiya ; 加藤, 俊吾 ; Kato, Shungo ; 三浦, 和彦 ; Miura, Kazuhiko ; 戸田, 敬 ; Toda, Kei ; 和田, 龍一 ; Wada, Ryuichi ; 竹内, 政樹 ; Takeuchi, Masaki ; 小林, 拓 ; Kobayashi, Hiroshi ; 土器屋, 由紀子 ; Dokiya, Yukiko ; 畠山, 史郎 ; Hatakeyama, Shiro
概要:
At the summit of Mt. Fuji in July and August from 2012 to 2018, 27 kinds of anthropogenic volatile organic compounds (AV
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OCs) and 6 types of biogenic volatile organic compounds (BVOCs) in the air and in cloud water were determined. AVOCs occupied about 90％ of the VOCs in the cloud water (volume-weighted mean VOCs concentration: 2.07 nM, n＝159) and the main component was toluene, reflecting its high concentration in the ambient air. The concentration of the AVOCs in the cloud water was high when the airmass was transported from the southern continent and was about 1.5 times higher than that when it came from the ocean. The concentration of toluene in the cloud water decreased exponentially with the increase in the total ion concentration. The concentrations of some VOCs such as chloroform, o-xylene, and limonen in the cloud water were several times higher than their Henryʼs law predicted values. Among the chlorinated hydrocarbons, highly hydrophobic chloroform was more concentrated than dichloromethane in the cloud water. Atmospheric surfactants such as HULIS (Humic-like Substances) could affect the enrichment of the VOCs in the cloud water even in the free troposphere.
2010年から2018年までの7月と8月に富士山頂（標高3,776 m）で大気および雲水を採取して、27種類の人為起源揮発性有機化合物 (AVOCs) （塩素化炭化水素16種、単環芳香族炭化水素8種、二環芳香族炭化水素3種）と6種類の生物起源揮発性有機化合物を分析した。雲水中VOCs （体積加重平均VOCs濃度： 2.07 nM、n＝159）の約9割はAVOCsであり、主成分はトルエンであった。これは富士山頂における大気中トルエン濃度が高いことを反映していた。雲水中AVOCs濃度は空気塊が大陸南部から輸送されたときに高く、最低濃度を示した海洋由来時の約1.5倍であった。雲水中トルエン濃度は総無機イオンの低下とともに指数関数的に減少した。雲水中クロロホルム、o-キシレン、リモネン濃度は大気中濃度とヘンリー定数から求めた計算値に比べて実測値は数倍高く、ヘンリー則からの予測値以上に濃縮されていた。疎水性が高いVOCsほど雲水に高濃縮されており、自由対流圏における雲水でもHULIS （フミン様物質）のような界面活性物質がVOCsの高濃縮に関与していることが示唆された。 続きを見る |
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| 49.
論文（リポジトリ） |
論文（リポジトリ）
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Omori, Yasutaka ; Hosoda, Masahiro ; Takahashi, Fumiaki ; Sanada, Tetsuya ; Hirao, Shigekazu ; Ono, Koji ; Furukawa, Masahide
概要:
The radiation doses from natural radiation sources in Japan are reviewed using the latest knowledge. The United Nations
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Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) and the Nuclear Safety Research Association report the annual effective doses from cosmic rays, terrestrial radiation, inhalation, and ingestion as natural sources. In this paper, the total annual effective dose from cosmic-ray exposure is evaluated as 0.29 mSv. The arithmetic mean of the annual effective dose from external exposure to terrestrial radiation is 0.33 mSv for the Japanese population using the data of nationwide surveys by the National Institute of Radiological Sciences. Previously in Japan, although three different groups have conducted nationwide indoor radon surveys using passive-type radon monitors, to date only the Japan Chemical Analysis Center (JCAC) has performed a nationwide radon survey using a unified method for radon measurements conducted indoor, outdoor, and in the workplace. Consequently, the JCAC results are used for the annual effective dose from radon and that for radon inhalation is estimated as 0.50 mSv using a current dose conversion factor. In this paper, UNSCEAR values are used for the mean indoor and outdoor thoron-progeny concentrations, and the annual effective dose from thoron is reported as 0.09 mSv. Thus, the annual effective dose from radon and thoron inhalation is 0.59 mSv. From a JCAC large-scale survey of foodstuffs, the committed effective dose from the main radionuclides in dietary intake is 0.99 mSv. Finally, the Japanese population dose from natural radiation is given as 2.2 mSv, which is similar to the reported global average of 2.4 mSv.
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| 50.
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論文（リポジトリ）
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Nakamura, Hideta ; Kinjo, Takeshi ; Arakaki, Wakako ; Miyagi, Kazuya ; Tateyama, Masao ; Fujita, Jiro
概要:
論文
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