1.

論文(リポジトリ)

論文(リポジトリ)
Imura, Yoshimi ; Nakamura, Ichiro ; Juntasin, Weenaporn ; Hossain, Mohammad Amzad ; Thaikua, Sarayut ; Poungkaew, Rattikan ; Kawamoto, Yasuhiro
出版情報: Agronomy.  14  pp.1-14,  2024-02-29.  © 2024 by the authors. Licensee MDPI, Basel, Switzerland.
概要: Two field trials were conducted in Northern Thailand from 2018 to 2020 to determine the best manual harvesting method fo r maximizing seed yield and seed quality of two Urochloa ruziziensis cultivars, cv. OKI-1 and cv. Br-203. Four manual seed harvesting methods were implicated in a randomized complete block design with four replicates. The four methods were as follows: knocking seeds from seedheads into a nylon net receptacle and collecting them once every day (T1); knocking seeds from seedheads into a nylon net receptacle and collecting them once every three days (T2); allowing ripe seeds to fall into a nylon net sheet that was stretched as a receptacle beneath the seedheads and collecting seeds once every five days (T3); and covering the tied seedheads with a nylon net bag and collecting seeds once every five days (T4). The highest pure seed yield was obtained from T3 in cv. Br-203 (333.11 kg/ha), as well as the highest trend in cv. OKI-1 (534.67 kg/ha). T3 produced 22–46% and 11–27% more pure germinated seed yields than the other methods in cv. Br-203 and cv. OKI-1, respectively. As a result, T3 was recommended for higher seed yield, convenient seed harvest, and reduced manual seed harvest time. 続きを見る
2.

論文(リポジトリ)

論文(リポジトリ)
Farooqi, Javed Ahmad ; Ono, Hiroko
出版情報: Japan Architectural Review.  7  pp.1-15,  2024-01-03.  Japan Architectural Review published by John Wiley & Sons Australia, Ltd on behalf of Architectural Institute of Japan.
概要: This study evaluates land use transformation in Kandahar’s old city, also known as Ahmad Shahi city, the birthplace and first capital of modern Afghanistan. The city consists of four rectangular quarters and is surrounded by a high strong mud wall, entrance gates, and a moat. In the early 20th century, the city experienced significant and arbitrary expansion, which certainly affected the urban fabric of the area, the streets were widened, and the city wall, towers, and gates were demolished, and the area was added to the construction of new government buildings, commercial establishments, and residential plots. This study aims to evaluate the alterations in the old city’s urban morphology, culture, and sociology by conducting a comparative analysis of three maps from different time periods and considering various factors within the target area. 続きを見る
3.

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論文(リポジトリ)
宮国, 薫子 ; Miyakuni, Kaoruko
出版情報: 琉球大学経営研究 — University of the Ryukyus Management Research.  pp.1-15,  2024-01.  国際地域創造学部 経営プログラム — Faculty of Global and Regional Studies, Management Program
概要: Tourism is one of the major economic drivers of small island developing nations (SIDs). Republic of Palau is one of the countries which depends heavily on tourism for their economy. In 2015, United Nations adopted Sustainable Development Goals (SDGs) and required member nations to submit Voluntary National Review (VNR) to develop their economies guided by SDGs. This thesis aims to clarify the relationship between tourism and SDGs by introducing history, culture, tourism, and VNR of Republic of Palau regarding SDGs 8 (Decent Work and Economic Growth), 12 (Responsible Production and Consumption), and 14 (Life below Water) . 続きを見る
4.

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論文(リポジトリ)
Ito, Masahiko
出版情報: Ryukyu Mathematical Journal.  36  pp.1-47,  2023-12-28.  琉球大学理学部数理科学教室
概要: We provide explicit expressions for two types of first order q-difference systems for the Jackson integral of symmetric Selberg type. One is the q- difference system known to be the q-KZ equation and the other is the q-difference system for parameters different from the q-KZ equation. We use a basis of the systems introduced by Matsuo in his study of the q-KZ equation. As a result, the similarity of these two systems is discussed by concrete calculations. Interme- diate calculations are made use of the Riemann-Hilbelt method for q-difference equation from connection matrix established by Aomoto. 続きを見る
5.

論文(リポジトリ)

論文(リポジトリ)
Kimoto, Kazufumi
出版情報: Ryukyu Mathematical Journal.  36  pp.49-68,  2023-12-28.  琉球大学理学部数理科学教室
概要: We establish a formula for the two-variable zeta functions for graphs introduced by Lorenzini, and use it to give explicit formulas of the zeta functions for dipole graphs, doubled trees and friendship graphs. We observe that the two-variable zeta functions for these graphs have a unified formula expressed using the Tutte polynomials. 続きを見る
6.

論文(リポジトリ)

論文(リポジトリ)
Sudo, Takahiro
出版情報: Ryukyu Mathematical Journal.  36  pp.69-112,  2023-12-28.  琉球大学理学部数理科学教室
概要: We study the entire cyclic cohomology theory for Banach algebras by following a part of the noncommutative geometric theory invented by Connes.
7.

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論文(リポジトリ)
Toda, Kei ; Obolkin, Vladimir ; Ohira, Shin-Ichi ; Saeki, Kentaro
出版情報: communications biology.  pp.1-10,  2023-11-24.  Springer Nature
概要: Phytoplanktonic dinoflagellates form colonies between vertical ice crystals during the icemelting season in Lake Baikal, but how the plankton survive the freezing conditions is not known. Here we show that the phytoplankton produces large amounts of dimethylsulfoniopropionate (DMSP), which is best-known as a marine compound. Lake-water DMSP concentrations in the spring season are comparable with those in the oceans, and colony water in ice exhibits extremely high concentrations. DMSP concentration of surface water correlates with plankton density and reaches a maximum in mid-April, with temperature-dependent fluctuations. DMSP is released from plankton cells into water in warm days. DMSP is a characteristic osmolyte of marine algae; our results demonstrate that freshwater plankton, Gymnodinium baicalense, has DMSP-producing ability, and efficiently uses the limited sulfur resource (only 1/500 of sea sulfate) to survive in freshwater ice. Plankton in Lake Baikal do not need an osmolyte, and our results clearly indicate that DMSP plays a cryoprotective role. DMSP, although a characteristic marine compound, could also be an important zwitterion for algae of other boreal lakes, alpine snow, and glaciers. 続きを見る
8.

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論文(リポジトリ)
Hanzawa, Eiko ; Sasaki, Kazuhiro ; Nagai, Shinsei ; Obara, Mitsuhiro ; Fukuta, Yoshimichi ; Uga, Yusaku ; Miyao, Akio ; Hirochika, Hirohiko ; Higashitani, Atsushi ; Maekawa, Masahiko ; Sato, Tadashi
出版情報: Rice.  6  2023-11-11.  Springer
URL: http://hdl.handle.net/20.500.12000/0002019894
概要: Background: Root system architecture is an important trait affecting the uptake of nutrients and water by crops. Shallower root systems preferentially take up nutrients from the topsoil and help avoid unfavorable environments in deeper soil layers. We have found a soil-surface rooting mutant from an M2 population that was regenerated from seed calli of a japonica rice cultivar, Nipponbare. In this study, we examined the genetic and physiological characteristics of this mutant. Results: The primary roots of the mutant showed no gravitropic response from the seedling stage on, whereas the gravitropic response of the shoots was normal. Segregation analyses by using an F2 population derived from a cross between the soil-surface rooting mutant and wild-type Nipponbare indicated that the trait was controlled by a single recessive gene, designated as sor1. Fine mapping by using an F2 population derived from a cross between the mutant and an indica rice cultivar, Kasalath, revealed that sor1 was located within a 136-kb region between the simple sequence repeat markers RM16254 and 2935-6 on the terminal region of the short arm of chromosome 4, where 13 putative open reading frames (ORFs) were found. We sequenced these ORFs and detected a 33-bp deletion in one of them, Os04g0101800. Transgenic plants of the mutant transformed with the genomic fragment carrying the Os04g0101800 sequence from Nipponbare showed normal gravitropic responses and no soil-surface rooting. Conclusion: These results suggest that sor1, a rice mutant causing soil-surface rooting and altered root gravitropic response, is allelic to Os04g0101800, and that a 33-bp deletion in the coding region of this gene causes the mutant phenotypes. 続きを見る
9.

論文(リポジトリ)

論文(リポジトリ)
Osada, Yohei ; 長田, 庸平
出版情報: Fauna Ryukyuana.  68  pp.27-28,  2023-10-12.  琉球大学資料館 (風樹館)
URL: http://hdl.handle.net/20.500.12000/0002020042
概要: Tornodoxa paraleptopalta Ueda is newly recorded from Yakushima Island, Kagoshima Prefecture. The specimen of adult and t he male genitalia are shown. This species is recorded from the Ryukyu Islands for the first time.
ヒメハイジロキバガは大阪府産の標本に基づいて記載され, これまで日本 (本州, 九州) および台湾から知られていた. 大阪市立自然史博物館での標本調査において, 屋久島産の本種の標本が確認されたので, ここに記録する. 琉球列島では初記録である.
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10.

論文(リポジトリ)

論文(リポジトリ)
Osada, Yohei ; 長田, 庸平
出版情報: Fauna Ryukyuana.  68  pp.29-30,  2023-10-12.  琉球大学資料館 (風樹館)
URL: http://hdl.handle.net/20.500.12000/0002020043
概要: Lopharcha psathyra Diakonoff is newly recorded from Yakushima Island. The specimen and female genitalia are shown. This species is recorded from the Ryukyu Islands for the first time.
スジケマダラハマキはこれまで日本の本州, 四国, 九州から知られていた.寄主植物は, クスノキ科のシロダモとクスノキである. 大阪市立自然史博物館での標本調査において, 屋久島産の本種の標本が確認されたので, 琉球列島初記録としてここに記録する.
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11.

論文(リポジトリ)

論文(リポジトリ)
Osada, Yohei ; 長田, 庸平
出版情報: Fauna Ryukyuana.  68  pp.31-32,  2023-10-12.  琉球大学資料館 (風樹館)
URL: http://hdl.handle.net/20.500.12000/0002020044
概要: Caloptilia zachrysa (Meyrick) is newly recorded from Yakushima Island. A female adult of the species and female genitali a are shown.
リンゴの害虫として知られるリンゴハマキホソガは日本, 台湾, 韓国, 中国, インド, スリランカに分布し, 日本国内では本州, 四国, 九州, 沖縄島から知られていた. 大阪市立自然史博物館での標本調査において, 屋久島産の本種の標本が確認されたので, ここに記録する.屋久島では初記録である.
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12.

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論文(リポジトリ)
Karasawa, Shigenori ; 唐沢, 重考 ; Nagata, Satomi ; 長田, 諭実 ; Honda, Masanao ; 本多, 正尚
出版情報: Fauna Ryukyuana.  68  pp.35-40,  2023-10-12.  琉球大学資料館(風樹館)
URL: http://hdl.handle.net/20.500.12000/0002020046
概要: Adult female and immature specimens of Typopeltis crucifer Pocock, 1894, were collected from Taramajima Island, Sakishim a Islands, southwestern Japan. A phylogenetic tree built using the mitochondrial COI gene (620 bp) of T. crucifer from Sakishima Islands revealed that specimens from Ishigakijima Island comprised two genetic groups. One of these groups formed a clade with specimens from Taramajima Island, and the other group was closely related to specimens from Iriomotejima Island. Our finding indicates that phylogeographic analyses on soil-dwelling invertebrates are expected to provide new insights into the paleogeographic processes that have shaped the Ryukyu Islands.
多良間島から雌成体と幼体のタイワンサソリモドキを採集した. ミトコンドリアCOI遺伝子 (620 bp) を用いた系統解析の結果, 石垣島には2つの遺伝グループがあり, そのうちの一つは多良間島の個体とクレードを構成することが分かった. また, もう一つのグループは西表島の個体とクレードを構成した. 本研究の結果, 土壌性無脊椎動物の系統地理学的研究は, 先島諸島の系統地理学に新たな知見をもたらすことを示唆する.
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13.

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論文(リポジトリ)
Nomura, Keiichi ; 野村, 恵一 ; Baird, Andrew H. ; Suzuki, Go ; 鈴木, 豪
出版情報: Fauna Ryukyuana.  68  pp.41-51,  2023-10-12.  琉球大学資料館(風樹館)
URL: http://hdl.handle.net/20.500.12000/0002020047
概要: A survey of Montipora corals fauna was conducted around Minami-Daitojima Island in June 2022 and a total of eight specie s (Montipora nodosa, Montipora sp. OKINAWATOGE, M. peltiformis, M. sinensis, M. stalagmites, M. turgescens, M. venosa and Montipora sp.) were recorded. Of these species, M. stalagmites was recorded for the first time in the 135 years since it was originally described. The species richness of the Montipora of Minami-Daito Island is very low when compared to other islands of the Ryukyu Archipelago. This is presumably because of the severe habitat environment of this oceanic island which has a steeply sloping bathymetry, little reef development, and extremely high wave energy.
2022年6月に南大東島でコモンサンゴ類相の調査が行われ, 合計8種(イワトゲコモンサンゴMontipora nodosa, オキナワトゲコモンサンゴMontipora sp. OKINAWATOGE, ムラサキコモンサンゴM. peltiformis, ナンサコモンサンゴM. sinensis, ダイトウコモンサンゴ (新称) M. stalagmites, ホンアバタコモンサンゴM. turgescens, フカアナコモンサンゴM. venosaならびにコモンサンゴ類の一種Montipora sp.)が記録された. これらの種のうち, ダイトウコモンサンゴは, タヒチからの原記載以来135年ぶりに記録された. 南大東島のコモンサンゴ類の種の豊富さは, 他の琉球列島の島々と比較して非常に低い. これは, この海洋島が急傾斜でサンゴ礁が発達せず, 波当たりが非常に強いという厳しい生息環境のためであると推察された.
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14.

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論文(リポジトリ)
Shinzato, Yuki ; Zamami, Ryo ; Oshiro, Nanako ; Nakamura, Takuto ; Ishida, Akio ; Ohya, Yusuke ; Kohagura, Kentaro
出版情報: Biomedicines.  11  2023-07-21.  © 2023 by the authors. Licensee MDPI, Basel, Switzerland.
URL: http://hdl.handle.net/20.500.12000/0002020000
概要: The combination effects of smoking (SMK) and hyperuricemia (HU) on renal arteriolosclerosis in patients with IgA nephrop athy remain unknown. We examined the cross-sectional association between smoking (current or former) and renal arteriolar hyalinosis and wall thickening with or without HU [uric acid (UA) level 7 and 5 mg/dL in men and women] in 87 patients with IgA nephropathy who underwent renal biopsy. Arteriolar hyalinosis and wall thickening were assessed by the semiquantitative grading of arterioles. The SMK/HU subgroup showed the highest indices for hyalinosis and wall thickening, followed by the non-SMK/HU, SMK/non-HU, and non- SMK/non-HU subgroups. Multiple logistic analysis showed that SMK/HU, but not SMK/non-HU, was significantly associated with an increased risk of higher-grade renal arteriolar wall thickening. However, this did not occur with hyalinosis compared to non-SMK/non-HU. The adjusted odds ratio (95% confidence interval, p value) for SMK/HU was 12.8 (1.36–119, p < 0.05) for wall thickening. An association between SMK and renal arteriolar wall thickening might be prevalent only among patients with HU and in patients with IgA nephropathy. Further prospective studies are needed to determine whether patients with HU and SMK history exhibit rapid eGFR deterioration. 続きを見る
15.

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論文(リポジトリ)
Aoki, Yumi ; Takaesu, Yoshikazu ; Matsui, Kentaro ; Tokumasu, Takahiro ; Tani, Hideaki ; Takekita, Yoshiteru ; Kanazawa, Tetsufumi ; Kishimoto, Taishiro ; Tarutani, Seiichiro ; Hashimoto, Naoki ; Takeuchi, Hiroyoshi ; Mishima, Kazuo ; Inada, Ken
出版情報: Neuropsychopharmacology Reports.  2023-07-14.  © 2023 The Authors. Neuropsychopharmacology Reports published by John Wiley & Sons Australia, Ltd on behalf of the Japanese Society of Neuropsychopharmacology.
URL: http://hdl.handle.net/20.500.12000/0002019998
概要: Aim: Continued antipsychotic treatment is the key to preventing relapse. Maintenance antipsychotic monotherapy and optimal dose use are recommended for individuals with stable schizophrenia because of their undesirable effects. Decision aids (DAs) are clinical conversation tools that facilitate shared decision-making (SDM) between patients and health-care providers. This study aimed to describe the development process and results of acceptability testing of a DA for individuals with stable schizophrenia, considering (i) whether to continue high-dose antipsychotics or reduce to the standard dose and (ii) whether to continue two antipsychotics or shift to monotherapy. Methods: A DA was developed according to the guidelines for the appropriate use of psychotropic medications and International Patient Decision Aid Standards (IPDAS). First, a DA prototype was developed based on a previous systematic review and meta-analysis conducted for identifying the effects of continuing or reducing antipsychotic treatment. Second, mixed-method survey was performed among individuals with schizophrenia and health-care providers to modify and finalize the DA. Results: The DA consisted of an explanation of schizophrenia, options to continue high-dose antipsychotics or reduce to the standard dose, options to continue two antipsychotics or shift to monotherapy, pros and cons of each option, and a value-clarification worksheet for each option. The patients (n = 20) reported acceptable language use (75%), adequate information (75%), and well-balanced presentation (79%). Health-care providers (n = 20) also provided favorable overall feedback. The final DA covered six IPDAS qualifying criteria. Conclusion: A DA was successfully developed for schizophrenia, considering whether to reduce antipsychotics, which can be used in the SDM process. 続きを見る
16.

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論文(リポジトリ)
Kitajima Eiji ; Sato Takashi ; Kurata Koji ; Miyata Ryota
出版情報: PLOS ONE.  18  2023-06-23.  © 2023 Kitajima et al.
URL: http://hdl.handle.net/20.500.12000/0002019996
概要: We propose a framework to analyze the relationship between the movement features of a wheel gymnast around the mounting phase of Unit 2 of the vault event and execution (Escore) deductions from a machine-learning perspective. We first developed an automation system from a video of a wheel gymnast performing a tuck-front somersault to extract the four frames highlighting its Unit 2 performance of the vault event, such as take-off, pikemount, the starting point of time on the wheel, and final position before the thrust. We implemented this automation using recurrent all-pairs field transforms (RAFT) and XMem, i.e., deep network architectures respectively for optical flow estimation and video object segmentation. We then used a markerless pose-estimation system called OpenPose to acquire the coordinates of the gymnast’s body joints, such as shoulders, hips, and knees then calculate the joint angles at the extracted video frames. Finally, we constructed a regression model to estimate the E-score deductions during Unit 2 on the basis of the joint angles using an ensemble learning algorithm called Random Forests, with which we could automatically select a small number of features with the nonzero values of feature importances. By applying our framework of markerless motion analysis to videos of male wheel gymnasts performing the vault, we achieved precise estimation of the E-score deductions during Unit 2 with a determination coefficient of 0.79. We found the two movement features of particular importance for them to avoid significant deductions: time on the wheel and angles of knees at the pike-mount position. The selected features well reflected the maturity of the gymnast’s skills related to the motions of riding the wheel, easily noticeable to the judges, and their branching conditions were almost consistent with the general vault regulations. 続きを見る
17.

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論文(リポジトリ)
Futenma, Kunihiro ; Takaesu, Yoshikazu ; Komada, Yoko ; Shimura, Akiyoshi ; Okajima, Isa ; Matsui, Kentaro ; Tanioka, Kosuke ; Inoue, Yuichi
出版情報: Frontiers in Psychiatry.  14  2023-05-19.  © 2023 Futenma, Takaesu, Komada, Shimura, Okajima, Matsui, Tanioka and Inoue.
URL: http://hdl.handle.net/20.500.12000/0002019997
概要: Delayed sleep–wake phase disorder (DSWPD) is a sleep disorder in which the habitual sleep–wake timing is delayed, result ing in difficulty in falling asleep and waking up at the desired time. Patients with DSWPD frequently experience fatigue, impaired concentration, sleep deprivation during weekdays, and problems of absenteeism, which may be further complicated by depressive symptoms. DSWPD is typically prevalent during adolescence and young adulthood. Although there are no studies comparing internationally, the prevalence of DSWPD is estimated to be approximately 3% with little racial differences between Caucasians and Asians. The presence of this disorder is associated with various physiological, genetic and psychological as well as behavioral factors. Furthermore, social factors are also involved in the mechanism of DSWPD. Recently, delayed sleep phase and prolonged sleep duration in the young generation have been reported during the period of COVID-19 pandemic-related behavioral restrictions. This phenomenon raises a concern about the risk of a mismatch between their sleep–wake phase and social life that may lead to the development of DSWPD after the removal of these restrictions. Although the typical feature of DSWPD is a delay in circadian rhythms, individuals with DSWPD without having misalignment of objectively measured circadian rhythm markers account for approximately 40% of the cases, wherein the psychological and behavioral characteristics of young people, such as truancy and academic or social troubles, are largely involved in the mechanism of this disorder. Recent studies have shown that DSWPD is frequently comorbid with psychiatric disorders, particularly mood and neurodevelopmental disorders, both of which have a bidirectional association with the pathophysiology of DSWPD. Additionally, patients with DSWPD have a strong tendency toward neuroticism and anxiety, which may result in the aggravation of insomnia symptoms. Therefore, future studies should address the effectiveness of cognitive-behavioral approaches in addition to chronobiological approaches in the treatment of DSWPD. 続きを見る
18.

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論文(リポジトリ)
Hayward, Philip ; Kearney, Christine
出版情報: Okinawan Journal of Island Studies.  4  pp.1-18,  2023-05-15.  Research Institute for Islands and Sustainability
19.

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論文(リポジトリ)
Albert, Patrick Donald ; Purifoy, Matthew
出版情報: Okinawan Journal of Island Studies.  4  pp.19-34,  2023-05-15.  Research Institute for Islands and Sustainability
20.

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論文(リポジトリ)
Hinekura, Smith
出版情報: Okinawan Journal of Island Studies.  4  pp.89-90,  2023-05-15.  Research Institute for Islands and Sustainability
21.

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論文(リポジトリ)
Naputi, Francine M.S.N.
出版情報: Okinawan Journal of Island Studies.  4  pp.91-93,  2023-05-15.  Research Institute for Islands and Sustainability
22.

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論文(リポジトリ)
Robie, David
出版情報: Okinawan Journal of Island Studies.  4  pp.94-96,  2023-05-15.  Research Institute for Islands and Sustainability
23.

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論文(リポジトリ)
Vunidilo, Tarisi
出版情報: Okinawan Journal of Island Studies.  4  pp.97-99,  2023-05-15.  Research Institute for Islands and Sustainability
24.

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論文(リポジトリ)
Barnett, Samantha
出版情報: Okinawan Journal of Island Studies.  4  pp.100-101,  2023-05-15.  Research Institute for Islands and Sustainability
25.

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論文(リポジトリ)
Harris, Usha Sundar
出版情報: Okinawan Journal of Island Studies.  4  pp.102-103,  2023-05-15.  Research Institute for Islands and Sustainability
26.

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論文(リポジトリ)
Papoutsaki, Evangelia
出版情報: Okinawan Journal of Island Studies.  4  pp.104-105,  2023-05-15.  Research Institute for Islands and Sustainability
27.

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論文(リポジトリ)
Johnson, Henry
出版情報: Okinawan Journal of Island Studies.  4  pp.106-108,  2023-05-15.  Research Institute for Islands and Sustainability
28.

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論文(リポジトリ)
Kirk, Gwyn
出版情報: Okinawan Journal of Island Studies.  4  pp.109-116,  2023-05-15.  Research Institute for Islands and Sustainability
29.

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論文(リポジトリ)
Espina, Tabitha ; Ong, Josephine Faith
出版情報: Okinawan Journal of Island Studies.  4  pp.117-121,  2023-05-15.  Research Institute for Islands and Sustainability
30.

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論文(リポジトリ)
Laclé, Francielle
出版情報: Okinawan Journal of Island Studies.  4  pp.122-129,  2023-05-15.  Research Institute for Islands and Sustainability
31.

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論文(リポジトリ)
Kelman, Ilan
出版情報: Okinawan Journal of Island Studies.  4  pp.130-143,  2023-05-15.  Research Institute for Islands and Sustainability
32.

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論文(リポジトリ)
Frain, Sylvia C.
出版情報: Okinawan Journal of Island Studies.  4  pp.144-155,  2023-05-15.  Research Institute for Islands and Sustainability
33.

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論文(リポジトリ)
Vaughn, Kēhaulani ; Reilly, Brandon J. ; Flores, Alfred Peredo ; Anesi, Juliann
出版情報: Okinawan Journal of Island Studies.  4  pp.156-162,  2023-05-15.  Research Institute for Islands and Sustainability
34.

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論文(リポジトリ)
Cangah, Brenda
出版情報: Okinawan Journal of Island Studies.  4  pp.163-173,  2023-05-15.  Research Institute for Islands and Sustainability
35.

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論文(リポジトリ)
Hermes, Karin Louise
出版情報: Okinawan Journal of Island Studies.  4  pp.174-181,  2023-05-15.  Research Institute for Islands and Sustainability
36.

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論文(リポジトリ)
Fuste-Forne, Francesc
出版情報: Okinawan Journal of Island Studies.  4  pp.182-188,  2023-05-15.  Research Institute for Islands and Sustainability
37.

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論文(リポジトリ)
Karides, Marina ; Rodríguez-Coss, Noralis
出版情報: Okinawan Journal of Island Studies.  4  pp.189-197,  2023-05-15.  Research Institute for Islands and Sustainability
概要: The following is a curated conversation between Marina Karides and Noralis Rodríguez-Coss, who together founded the Isla nd Feminisms Project and continue to advance feminist, decolonial, and social justice approaches in island studies. With the publication of “Why Island Feminism?” (Karides 2017), conference sessions, and the establishment of the Island Feminisms Spring Series, begun in 2020, the co-founders suggest that the field of island studies was guided towards gender and women (see Gender and Island Communities 2020, edited by Gaini and Nielsen as an example). However, they argue that the field continues to struggle to incorporate feminist and intersectional frameworks analytically. Karides and Rodríguez-Coss explore the paucity of feminist grounding in island studies, which tends towards the approach of “add women and stir.” Their dialogue reveals grassroots island activism as the core of island feminisms, which they identify as a social justice project. 続きを見る
38.

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論文(リポジトリ)
Wheeler, Vehia ; Duong-Pedica, Anaïs
出版情報: Okinawan Journal of Island Studies.  4  pp.198-219,  2023-05-15.  Research Institute for Islands and Sustainability
39.

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論文(リポジトリ)
Forsyth, Meghan C.
出版情報: Okinawan Journal of Island Studies.  4  pp.1-26,  2023-05-15.  Research Institute for Islands and Sustainability
概要: The year 2020 marked the tricentennial of Acadian and French presence on Prince Edward Island, Canada’s smallest provinc e, located in the Gulf of Saint Lawrence on the Atlantic coast. Despite historical traumas and the pressures exerted by a majority Anglophone environment, the small Island Acadian population has persisted and thrived. Nevertheless, the process of anglicization that began in earnest in the 1860s continues to the present day. This article examines the goals, production, and reception of a mini web-documentary series about living in French on Prince Edward Island that aims to encourage the intergenerational transmission of the French language and foster a sense of legitimization and cultural pride. Complementing a long history of community activism around the Island’s French language and Acadian culture, the documentary project uses music, storytelling, and technology to promote cultural and linguistic sustainability. This article explores the role of music in the contemporary dynamics of sustaining, celebrating, and advocating for the French language and Francophone Acadian culture in this small island community. 続きを見る
40.

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論文(リポジトリ)
Robie, David
出版情報: Okinawan Journal of Island Studies.  4  pp.27-52,  2023-05-15.  Research Institute for Islands and Sustainability
概要: For more than a decade, the pioneering Pacific Media Centre at Aotearoa’s Auckland University of Technology led the way in journalism research and publication, publishing the globally ranked peer-reviewed journal Pacific Journalism Review, monographs, and a series of media and social justice books and documentaries. Perhaps even more important was the centre’s role in nurturing young and challenging Asia-Pacific student journalists and communicators seeking social change and providing them with the opportunity, support, and encouragement to enable them to become confident changemakers and community advocates. This article is a case study of a style of academic advocacy and activism that was characterised by its own multiethnic stakeholders’ advisory board as “the voice of the voiceless.” A feature was the “Talanoa journalism” model (Robie 2014), focused more on grassroots people and community resilience, especially faced with the global COVID-19 pandemic and climate crisis. The inspired initiative ended with a change of management to a more neoliberal approach to education at the university with scant appreciation for the vision. 続きを見る
41.

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論文(リポジトリ)
Bomai, Dick Witne ; Thomas, Verena ; Kauli, Jackie ; Spurgeon, Christina
出版情報: Okinawan Journal of Island Studies.  4  pp.53-70,  2023-05-15.  Research Institute for Islands and Sustainability
概要: This article examines the role of women in peacebuilding and in reducing accusations of sorcery and related violence amo ng the Yuri tribe in Papua New Guinea (PNG). The formation of the community-led peace movement YAKA (Yuri Alaiku Kuikane Association) in 2013 led to a stop of the tribal fights that frequently occurred among the Yuri people over several decades. Accusations of sorcery, previously related to tribal fights and contemporary forms of violent accusations, disproportionately affect women in the patriarchal PNG highland society. However, less documented are women’s roles in addressing sorcery accusation-related violence. Building on women’s agency and involvement in local peacebuilding, this paper investigates the contribution of women in mitigating sorcery accusations and related violence. The action research project discussed in this article included the local storytelling approach kapori and incorporated photovoice for participants to share their lived experiences. We examine the gendered dynamics in local activism and the cultural context of Yuri with regards to community well-being and leadership to inform future violence prevention strategies. Our research investigates the strategies of Yuri women to meaningfully contribute to peacebuilding and social cohesion to inform future violence prevention strategies. We demonstrate how Yuri women enact their agency in both private and public spaces, informed by empathy, traditional and Church values, family, and relational concepts. 続きを見る
42.

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Duong-Pedica, Anaïs
出版情報: Okinawan Journal of Island Studies.  4  pp.71-88,  2023-05-15.  Research Institute for Islands and Sustainability
概要: “La Pause Décoloniale” is a radio show and podcast from Kanaky/New Caledonia that explores women’s reflections, formulat ions of, and contributions to decolonization. Created in February 2022, it operates in a context of ongoing French settler colonialism and through a formal decolonization process. However, this formal decolonization process has been questioned and critiqued, especially when it comes to France’s interest to maintain its sovereignty in Kanaky/New Caledonia and in the Pacific region more generally. This paper explores “La Pause Décoloniale” as a feminist intervention by women to resist the despair and disappointment generated by the current political context. It discusses how the radio program came about, presents the members of the team and how they work collaboratively, and their vision of the relation between feminism and decolonization. The paper also reflects on the episodes produced and the importance of translation. It does so by connecting the practice of “La Pause Décoloniale” to the history of women’s political action in the Pacific and in Kanaky/New Caledonia and making visible the constellation of relations to people, to place(s), and to struggles that are necessary to meaningfully do the work of decolonization. 続きを見る
43.

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論文(リポジトリ)
Na’puti, Tiara R. ; Karides, Marina ; Ginoza, Ayano ; Papoutsaki, Evangelia
出版情報: Okinawan Journal of Island Studies.  4  pp.ⅰ-ⅴ,  2023-05-15.  Research Institute for Islands and Sustainability
44.

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論文(リポジトリ)
Aoki, Yumi ; Takaesu, Yoshikazu ; Inada, Ken ; Yamada, Hiroki ; Murao, Tomohiko ; Kikuchi, Toshiaki ; Takeshima, Masahiro ; Tani, Masayuki ; Mishima, Kazuo ; Otsubo, Tempei
出版情報: Frontiers in Psychiatry.  14  2023-05-12.  © 2023 Aoki, Takaesu, Inada, Yamada, Murao, Kikuchi, Takeshima, Tani, Mishima and Otsubo.
URL: http://hdl.handle.net/20.500.12000/0002019930
概要: Aim: We aimed to develop a decision aid (DA) for individuals with anxiety disorders who consider tapering benzodiazepine (BZD) anxiolytics, and if tapering, tapering BZD anxiolytics with or without cognitive behavioral therapy (CBT) for anxiety. We also assessed its acceptability among stakeholders. Methods: First, we conducted a literature review regarding anxiety disorders to determine treatment options. We cited the results of the systematic review and meta-analysis, which we conducted previously, to describe the related outcomes of two options: tapering BZD anxiolytics with CBT and tapering BZD anxiolytics without CBT. Second, we developed a DA prototype in accordance with the International Patient Decision Aid Standards. We carried out a mixed methods survey to assess the acceptability among stakeholders including those with anxiety disorders and healthcare providers. Results: Our DA provided information such as explanation of anxiety disorders, options of tapering or not tapering BZD anxiolytics (if tapering, the options of tapering BZD anxiolytics with or without CBT) for anxiety disorder, benefits and risks of each option, and a worksheet for value clarification. For patients (n = 21), the DA appeared to be acceptable language (86%), adequate information (81%), and well-balanced presentation (86%). The developed DA was also acceptable for healthcare providers (n = 10). Conclusion: We successfully created a DA for individuals with anxiety disorders who consider tapering BZD anxiolytics, which was acceptable for both patients and healthcare providers. Our DA was designed to assist patients and healthcare providers to involve decision-making about whether to taper BZD anxiolytics or not. 続きを見る
45.

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Takaesu, Yoshikazu ; Sakurai, Hitoshi ; Aoki, Yumi ; Takeshima, Masahiro ; Ie, Kenya ; Matsui, Kentaro ; Utsumi, Tomohiro ; Shimura, Akiyoshi ; Okajima, Isa ; Kotorii, Nozomu ; Yamashita, Hidehisa ; Suzuki, Masahiro ; Kuriyama, Kenichi ; Shimizu, Eiji ; Mishima, Kazuo ; Watanabe, Koichiro ; Inada, Ken
出版情報: Frontiers in Psychiatry.  14  2023-05-09.  © 2023 Takaesu, Sakurai, Aoki, Takeshima, Ie, Matsui, Utsumi, Shimura, Okajima, Kotorii, Yamashita, Suzuki, Kuriyama, Shimizu, Mishima, Watanabe and Inada.
URL: http://hdl.handle.net/20.500.12000/0002019971
概要: Purpose: There is a lack of evidence regarding answers for clinical questions about treating insomnia disorder. This stu dy aimed to answer the following clinical questions: (1) how to use each hypnotic and non-pharmacological treatment differently depending on clinical situations and (2) how to reduce or stop benzodiazepine hypnotics using alternative pharmacological and nonpharmacological treatments. Methods: Experts were asked to evaluate treatment choices based on 10 clinical questions about insomnia disorder using a nine-point Likert scale (1 = “disagree” to 9 = “agree”). The responses of 196 experts were collected, and the answers were categorized into first-, second-, and third-line recommendations. Results: The primary pharmacological treatment, lemborexant (7.3 2.0), was categorized as a first-line recommendation for sleep initiation insomnia, and lemborexant (7.3 1.8) and suvorexant (6.8 1.8) were categorized as the first-line recommendations for sleep maintenance insomnia. Regarding nonpharmacological treatments for primary treatment, sleep hygiene education was categorized as the first-line recommendation for both sleep initiation (8.4 1.1) and maintenance insomnia (8.1 1.5), while multicomponent cognitive behavioral therapy for insomnia was categorized as the second-line treatment for both sleep initiation (5.6 2.3) and maintenance insomnia (5.7 2.4). When reducing or discontinuing benzodiazepine hypnotics by switching to other medications, lemborexant (7.5 1.8) and suvorexant (6.9 1.9) were categorized as first-line recommendations. Conclusion: Expert consensus indicates that orexin receptor antagonists and sleep hygiene education are recommended as first-line treatments in most clinical situations to treat insomnia disorder. 続きを見る
46.

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Ngoc B. Nguyen ; Nguyet T. M. Nguyen ; Nhai T. Nguyen ; Linh H. Le ; Nghia T. La ; Thuy T. T. Nguyen ; Mary Jeany Yanoria ; Hayashi, Nagao ; Saito, Hiroki ; Obara, Mitsuhiro ; Sato, Tadashi ; Fukuta, Yoshimichi
出版情報: Breeding Science.  73  pp.193-203,  2023-04-25.  © 2023 Japanese Society of Breeding.
URL: http://hdl.handle.net/20.500.12000/0002019904
概要: A unique genetic variation with respect to blast resistance was clarified in 201 rice accessions from Vietnam. These acc essions were classified into three clusters—A, B1, and B2—based on their reactions to 26 standard differential blast isolates selected in Vietnam. Cluster A was the dominant cultivar group in Vietnam and the most susceptible of the three clusters. Cluster B1 was the smallest group and the most resistant. Cluster B2 was the second-most dominant group and of intermediate resistance between clusters A and B1. The percentages of accessions comprising each cluster varied by region and area. Accessions in cluster A were distributed widely throughout Vietnam and had the highest frequencies in both the Central and North regions. Accessions in cluster B2 were found with highest frequencies in the mountainous and intermediate areas of the North region. Accessions in cluster B1 were found with highest frequencies in the Central region and Red River Delta area (North region). These results suggest that rice accessions in Vietnam were basically susceptible (cluster A) or of intermediate resistance (cluster B2), and that high-resistance cultivars were mainly distributed in the low altitude areas, such as the Red River Delta area and Central region. 続きを見る
47.

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論文(リポジトリ)
Inagawa, Michiyo ; Nakao, Tatsuma
出版情報: Humanities and Social Sciences Communications.  10  2023-04-22.  © The Author(s) 2023
URL: http://hdl.handle.net/20.500.12000/0002019911
概要: Obtaining data from non-Western cultural contexts is essential for enhancing the crosscultural validity of attachment th eory. This study investigated the associations among maternal attachment style, maternal willingness to serve as an attachment figure, and children’s attachment security in middle childhood in Japan. Sample 1 included a nationwide web survey of 104 dyads of fifth and sixth graders and their mothers. Sample 2 included 53 dyads in an in-person questionnaire survey conducted in Kyoto. In both Samples 1 and 2, the results revealed (1) negative Spearman’s rank correlation coefficients between maternal attachment anxiety and children’s attachment security, (2) positive Pearson’s product-moment correlation coefficients between maternal willingness to serve as an attachment figure and children’s attachment security, and (3) negative Pearson’s product-moment correlation coefficients between maternal attachment anxiety and maternal willingness to serve as an attachment figure. Our data could enhance the cross-cultural validity of attachment in fifth and sixth graders, and suggest that the influence of maternal attachment styles on parental responsiveness changes in middle childhood. 続きを見る
48.

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論文(リポジトリ)
Higa, Sho ; Yamada, Koji ; Kamisato, Shihoko
出版情報: Sensors.  23  2023-04-16.  © 2023 by the authors. Licensee MDPI, Basel, Switzerland.
URL: http://hdl.handle.net/20.500.12000/0002019951
概要: When an electric wheelchair is operated using gaze motion, eye movements such as checking the environment and observing objects are also incorrectly recognized as input operations. This phenomenon is called the “Midas touch problem”, and classifying visual intentions is extremely important. In this paper, we develop a deep learning model that estimates the user’s visual intention in real time and an electric wheelchair control system that combines intention estimation and the gaze dwell time method. The proposed model consists of a 1DCNN-LSTM that estimates visual intention from feature vectors of 10 variables, such as eye movement, head movement, and distance to the fixation point. The evaluation experiments classifying four types of visual intentions show that the proposed model has the highest accuracy compared to other models. In addition, the results of the driving experiments of the electric wheelchair implementing the proposed model show that the user’s efforts to operate the wheelchair are reduced and that the operability of the wheelchair is improved compared to the traditional method. From these results, we concluded that visual intentions could be more accurately estimated by learning time series patterns from eye and head movement data. 続きを見る
49.

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Aoki, Yumi ; Takeshima, Masahiro ; Tsuboi, Takashi ; Katsumoto, Eiichi ; Udagawa, Ken ; Inada, Ken ; Watanabe, Koichiro ; Mishima, Kazuo ; Takaesu, Yoshikazu
出版情報: International Journal of Environmental Research and Public Health.  20  pp.5373-,  2023-04-03.  © 2023 by the authors. Licensee MDPI, Basel, Switzerland.
URL: http://hdl.handle.net/20.500.12000/0002019895
概要: Background: Although long-term use of benzodiazepines and z-drugs (BZDs) is not recommended, little is known about the s takeholders’ perceptions. This study aimed to assess and compare the perceptions of BZD use and decision making regarding its discontinuation between psychiatric outpatients and psychiatrists. Methods: A cross-sectional survey was conducted. Results: Of 104 outpatients, 92% were taking hypnotics and 96% were taking anxiolytics for a year, while 49% were willing to taper hypnotic/anxiolytics within a year of starting. Most psychiatrists felt that “patient and psychiatrist make the decision together on an equal basis” compared to patients (p < 0.001), while more patients felt that “the decision is (was) made considering the psychiatrists’ opinion” compared to psychiatrists (p < 0.001). Of 543 psychiatrists, 79% reported “patients were not willing to discontinue hypnotic/anxiolytic” whereas a certain number of patients conveyed “psychiatrists did not explain in enough detail about hypnotic/anxiolytic discontinuation such as procedure (18.3%), timing (19.2%), and appropriate condition (14.4%)”. Conclusion: The results suggest that the majority of psychiatric outpatients were taking hypnotic/anxiolytics for a long time against their will. There might be a difference in perceptions toward hypnotic/anxiolytic use and decision making for its discontinuation between psychiatric outpatients and psychiatrists. Further research is necessary to fill this gap. 続きを見る
50.

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論文(リポジトリ)
Iha, Takumi ; Tanaka, Junichi ; Nakata, Junichi
出版情報: 琉球大学理学部紀要.  pp.11-7,  2023-03-31.  琉球大学理学部
概要: As part of our project searching for antiviral molecules, a lipophilic extract of a sponge Amphimedon sp. collected at Iriomote Island was found to show antiviral activity against HCV. After bioassay-guided chromatographic separation, two pigments from the extract, mytiloxanthin (1) and chlorophyllone a (2), were identified as possible antiviral agents. 続きを見る
51.

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論文(リポジトリ)
Sua, Irene Yap ; Higa, Tatuso ; Tanaka, Junichi
出版情報: 琉球大学理学部紀要.  pp.17-13,  2023-03-31.  琉球大学理学部
概要: Five steroids 1-5 were isolated from a sponge Geodia sp. collected in the East China Sea. The structures were elucidated to be ergosterol analogs by analyzing spectroscopic data and identified by comparing the data with those published.
52.

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論文(リポジトリ)
Onaga, Shoki ; Nicole J, de Voogd ; Tanaka, Junichi
出版情報: 琉球大学理学部紀要.  pp.19-21,  2023-03-31.  琉球大学理学部
概要: A new mycalenitrile 1 was isolated from a lipophilic extract of the sponge Mycale sp. The structure of 1 was elucidated to be an analog of mycalenitriles by analyzing spectroscopic data and by comparing them with those reported. The olefinic position was estimated by observing a product ion in the MS/MS spectrum. 続きを見る
53.

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論文(リポジトリ)
Yamanaka, Takayuki
出版情報: 琉球大学教職センター紀要.  pp.173-182,  2023-03-31.  琉球大学教職センター
概要: Background and Objects: In 2017, MEXT revised the Course of Study which stressed on “Learning Roadmap”. Under this cours e of study, all subjects are focused on achieving the competencies which each subject has. Teachers seem to be struggling to handle the balance of “Learning” content and competencies. To solve this problem, “Roadmap-Creating by Students” might be one of the keys. Therefore, the study aims to analyze how “Roadmap- Creating by Students” effect students’ motivation and competencies. In this paper, the purpose of this study is to suggest an ideal roadmap for learning at elementary school English lessons should be designed. Research design and Method: In the first period of the lesson (What do you have on Mondays?, Junior Sunshine5, Lesson3), the teacher showed the goal of the lesson, then the students thought, talked, planned how the rest of periods of the lesson should be done. After that, the teacher created the rest period of the lesson to achieve the goal of the lesson. Therefore, this paper will show the roadmap-creating by the students. The lesson which this study shows was allocated 7 hours (1 hour-45min). Results: In the results, following and conducting the lesson based on the roadmap created by the students, they were highly motivated and participated in English lesson. In addition to this, the scores of the students’ paper tests are statistically differences in some parts of the test by using SPSS (Version 25). Discussion and Implication: As for Students’ motivation, the statistically analysis among 3 classes (including non-experimental class) indicate that there are no significant differences. As for the score of the paper test, clear differences between three classes can be observed. 続きを見る
54.

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Tomita, Rena ; Vincent Pamugas Reyes, ; Fukuta, Yoshimichi ; Emily Waringa Gichuhi, ; Kikuta, Mayumi ; Daniel Makori Menge, ; Doi, Kazuyuki ; Makihara, Daigo
出版情報: Plants.  12  pp.863-,  2023-02-24.  © 2023 by the authors. Licensee MDPI, Basel, Switzerland.
URL: http://hdl.handle.net/20.500.12000/0002019945
概要: In Kenya’s rice-growing areas, Basmati varieties have been produced in monoculture since the late 1980s. This has result ed in the breakdown of the resistance (R) gene-mediated response of the local Basmati varieties to blast disease caused by Pyricularia oryzae. To improve blast resistance in Kenyan Basmati varieties, continuous identification of R genes and suitable breeding materials for Basmati are necessary. Longistaminata chromosome segment introgression lines (LCSILs) with the Kernel Basmati genetic background, developed using a rice line called potential low-input adaptable-1 (pLIA-1) derived from a cross between Taichung 65 (T65) (a rice variety in the Japonica Group) and O. longistaminata, are expected to contain useful blast R genes derived from O. longistaminata or T65. In this study, we investigated the genetic variation of blast R genes in LCSILs and their parents by using a new international differential system for designating blast races based on the gene-for-gene theory and molecular characterization using single nucleotide polymorphism (SNP) markers. LCSILs and their parents were classified into three groups—A, B1, and B2—based on reaction patterns to the standard differential blast isolates (SDBIs). Group A, including pLIA-1, showed the highest resistance in all groups, followed by groups B1 and B2. Kernel Basmati in group B1 was considered to possess Pik-p or Pi7(t), Pi19(t), and other unknown R genes. In addition to these R genes, LCSIL 6, 12, 27, 28, and 40, in group A, were determined to possess one of Pish, Piz-t, or both genes that confer resistance to the Kenyan blast races. These lines can be used for efficiently pyramiding blast R genes in the local Basmati varieties. 続きを見る
55.

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Sakurai, Hitoshi ; Inada, Ken ; Aoki, Yumi ; Takeshima, Masahiro ; Ie, Kenya ; Kise, Morito ; Yoshida, Eriko ; Tsuboi, Takashi ; Yamada, Hisashi ; Hori, Hikaru ; Inada, Yasushi ; Shimizu, Eiji ; Mishima, Kazuo ; Watanabe, Koichiro ; Takaesu, Yoshikazu
出版情報: 43  pp.188-194,  2023-02-21.  © 2023 The Authors. Neuropsychopharmacology Reports published by John Wiley & Sons Australia, Ltd on behalf of the Japanese Society of Neuropsychopharmacology.
URL: http://hdl.handle.net/20.500.12000/0002019954
概要: Aims: Treatment guidelines with respect to unspecified anxiety disorder have not been published. The aim of this study w as to develop a consensus among field experts on the management of unspecified anxiety disorder. Methods: Experts were asked to evaluate treatment choices based on eight clinical questions concerning unspecified anxiety disorder using a nine-point Likert scale (1 = “disagree” to 9 = “agree”). According to the responses from 119 experts, the choices were categorized into first-, second-, and third-line recommendations.aResults: Benzodiazepine anxiolytic use was not categorized as a first-linearecommendationafor the primary treatment of unspecified anxiety disorder, whereas multipleanonpharmacological treatment strategies, including coping strategies (7.9 ± 1.4), psychoeducationafor anxiety (7.9 ± 1.4), lifestyle changes (7.8 ± 1.5), and relaxation techniquesa(7.4 ± 1.8), were categorized as first-linearecommendations. Various treatmentastrategies were categorized as first-linearecommendations when a benzodiazepineaanxiolytic drug did not improve anxiety symptoms, that is, differential diagnosisa(8.2 ± 1.4), psychoeducation for anxiety (8.0 ± 1.5), coping strategies (7.8 ± 1.5), lifestyleachanges (7.8 ± 1.5), relaxation techniques (7.2 ± 1.9), and switching to selectiveaserotonin reuptake inhibitors (SSRIs) (7.0 ± 1.8). These strategies were also highly endorsedawhen tapering the dosage of or discontinuing benzodiazepine anxiolytic drugs.aThere was no first-linearecommendation regarding excusable reasons for continuingabenzodiazepine anxiolytics. Conclusions: The field experts recommend that benzodiazepine anxiolytics should not be used as a first-line option for patients with unspecified anxiety disorder. Instead, several nonpharmacological interventions and switching to SSRIs were endorsed for the primary treatment of unspecified anxiety disorder and as alternatives to benzodiazepine anxiolytics. 続きを見る
56.

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Takeshima, Masahiro ; Aoki, Yumi ; Ie, Kenya ; Katsumoto, Eiichi ; Tsuru, Eiichi ; Tsuboi, Takashi ; Inada, Ken ; Kise, Morito ; Watanabe, Koichiro ; Mishima, Kazuo ; Takaesu, Yoshikazu
出版情報: Frontiers in Psychiatry.  14  2023-02-14.  © 2023 Takeshima, Aoki, Ie, Katsumoto, Tsuru, Tsuboi, Inada, Kise, Watanabe, Mishima and Takaesu.
URL: http://hdl.handle.net/20.500.12000/0002019961
概要: Introduction: Benzodiazepines and non-benzodiazepines are still widely prescribed despite safety concerns and the introd uction of novel hypnotics (orexin receptor antagonists [ORA] and melatonin receptor agonists [MRA]), which may be influenced by physicians’ attitudes toward hypnotics. Methods: A questionnaire survey was administered to 962 physicians between October 2021 and February 2022, investigating frequently prescribed hypnotics and the reasons for their selection. Results: ORA were the most frequently prescribed at 84.3%, followed by nonbenzodiazepines (75.4%), MRA (57.1%), and benzodiazepines (54.3%). Compared to non-frequent prescribers of hypnotics, a logistic regression analysis showed that frequent ORA prescribers were more concerned with efficacy (odds ratio [OR]: 1.60, 95% confidence interval [CI]: 1.01–2.54, p = 0.044) and safety (OR: 4.52, 95% CI: 2.99–6.84, p < 0.001), frequent MRA prescribers were more concerned with safety (OR: 2.48, 95% CI: 1.77–3.46, p < 0.001), frequent non-benzodiazepine prescribers were more concerned with efficacy (OR: 4.19, 95% CI: 2.91–6.04, p < 0.001), and frequent benzodiazepine prescribers were more concerned with efficacy (OR: 4.19, 95% CI: 2.91–6.04, p < 0.001) but less concerned with safety (OR: 0.25, 95% CI: 0.16–0.39, p < 0.001). Discussion: This study suggested that physicians believed ORA to be an effective and safe hypnotic and were compelled to prescribe benzodiazepine and nonbenzodiazepine frequently, choosing efficacy over safety. 続きを見る
57.

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Hata, Harutaka ; 畑, 晴陵 ; Sado, Tetsuya ; 佐土, 哲也 ; Hirasaka, Hiroshi ; 平坂, 寛 ; Nakae, Masanori ; 中江, 雅典
出版情報: Fauna Ryukyuana.  66  pp.3-8,  2023-01-21.  琉球大学資料館 (風樹館)
URL: http://hdl.handle.net/20.500.12000/0002019594
概要: Single specimens of the Arrowfin Bigeye Priacanthus sagittarius Starnes, 1988 (Teleostei: Priacanthidae), collected off the Pacific coast of Boso Peninsula (Chiba Prefecture) and Ishigaki-jima Island (Yaeyama Islands, Okinawa Prefecture), represent the first confirmed records of the species from those prefectures. Previous records of the species in the Pacific coast of Japanese waters have been limited to west of Kanagawa Prefecture, with records from Okinawa Prefecture being unconfirmed or lacking detailed locality data.
千葉県南房総市沖および沖縄県石垣島近海において, キントキダイ科魚類の1種, ミナミキントキPriacanthus sagittarius Starnes, 1988が1個体ずつ採集された. 本種は日本の太平洋沿岸において神奈川県以西からのみ知られていたほか, 沖縄県における証拠標本に基づく確実な記録がなかったことから, 本報告は標本に基づく本種の千葉県と沖縄県における初めての記録となる.
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58.

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論文(リポジトリ)
Tamaki, Tomoko ; Karube, Kennosuke ; Sakihama, Shugo ; Tsuruta, Yuma ; Awazawa, Ryoko ; Hayashi, Masaki ; Nakada, Norihiro ; Matsumoto, Hirofumi ; Yagi, Nobutake ; Ohshiro, Kazuiku ; Nakazato, Iwao ; Kitamura, Sakiko ; Nishi, Yukiko ; Miyagi, Takuya ; Yamaguchi, Sayaka ; Nakachi, Sawako ; Morishima, Satoko ; Masuzaki, Hiroaki ; Takahashi, Kenzo ; Fukushima, Takuya ; Wada, Naoki
出版情報: Modern Pathology.  36  pp.74-89,  2023-08.  © 2023 THE AUTHORS. Published by Elsevier Inc. on behalf of the United States & Canadian Academy of Pathology.
URL: http://hdl.handle.net/20.500.12000/0002019896
概要: Adult T-cell leukemia/lymphoma (ATLL) is a mature T-cell tumor caused by human T-lymphotropic virus type 1 (HTLV-1). The typical ATLL immunophenotypes are described in the 2017 World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues (positive: CD2, CD3, CD5, CD4, and CD25; negative: CD7, CD8, and cytotoxic markers; and partially positive: CD30, CCR4, and FOXP3). However, limited studies are available on the expression of these markers, and their mutual relationship remains unknown. Furthermore, the expression status of novel markers associated with T-cell lymphomas, including Th1 markers (T-bet and CXCR3), Th2 markers (GATA3 and CCR4), T follicular helper markers (BCL6, PD1, and ICOS), and T-cell receptor (TCR) markers, and their clinicopathologic significance is unclear. In this study, we performed >20 immunohistochemical stains in 117 ATLL cases to determine the comprehensive immunophenotypic profile of ATLL, which were compared on the basis of clinicopathologic factors, including morphologic variants (pleomorphic vs anaplastic), biopsy locations, treatments, Shimoyama classification-based clinical subtype, and overall survival. CD3þ/CD4þ/CD25þ/CCR4þ was considered a typical immunophenotype of ATLL, but approximately 20% of cases did not conform to this pattern. Simultaneously, the following new findings were obtained: (1) most cases were negative for TCR-b and TCR-d (104 cases, 88.9%), indicating the usefulness of negative conversion of TCR expression to provide differentiation from other T-cell tumors; (2) the positivity of CD30 and CD15 and the negativity of FOXP3 and CD3 were significantly associated with anaplastic morphology; and (3) atypical cases, such as T follicular helper marker-positive (12 cases, 10.3%) and cytotoxic molecule-positive cases (3 cases, 2.6%), were identified. No single markers could predict the overall survival among patients with acute/lymphoma subtypes of ATLL. The results of this study illustrate the diversity of ATLL phenotypes. In Tcell tumors occurring in HTLV-1 carriers, the possibility of ATLL should not be eliminated even when the tumor exhibits an atypical phenotype, and the confirmation of HTLV-1 in the tissue is recommended. 続きを見る
59.

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論文(リポジトリ)
Higa, Marina ; Katsuren, Eisuke ; Tayag, Jose Carlos S. ; Iwabuchi, Masashi ; Ohya, Yusuke ; Shiohira, Hideo ; Nakamura, Katsunori
出版情報: BPB Reports.  6  pp.98-102,  2023.  © 2023 The Pharmaceutical Society of Japan
URL: http://hdl.handle.net/20.500.12000/0002019975
概要: Amiodarone and tramadol are known to have drug-drug interactions that potentiate the effects of the anticoagulant warfar in. Herein we report a case which suggests increasing prothrombin time-international normalized ratio (PT-INR) and PT-INR/dose ratio due to the concomitant administration of warfarin, amiodarone (a cytochrome P450 2C9 inhibitor) and tramadol (an enhancer of anticoagulant effects of warfarin). A 72-year-old woman underwent emergency surgery following a suspected non-obstructive mesenteric ischemia, and diagnosis was confirmed. After surgery, the patient was given 2 mg/day of WF, and tramadol/acetaminophen, followed by amiodarone. After the concomitant dose of the triple combination, the PT-INR increased to over 7.02 (above the upper limit of the laboratory). The physician consulted the pharmacist for dose adjustment, and the pharmacist recommended a reduction in the dose to 0.5 mg. After restarting warfarin, PT-INR was controlled to 1.66–2.02. However, the PT-INR/dose ratio increased from 1.22 to 3.32–4.04 compared to the initial dose. The results suggest that these enhanced anticoagulant effects may be due to the inhibition of WF metabolism. Although the patient underwent resection of the small intestine, the effects of oral vitamin K1 were observed one day after administration. In conclusion, frequent PT-INR monitoring, and pharmacist intervention such as the assessment and dose adjustment in this report should be beneficial during anticoagulation therapy when multiple concomitant medications with suspected drug-drug interactions are present. 続きを見る
60.

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Yamashita, Hirotaka ; Matsuhara, Hiroki ; Tanaka, Hiroyuki ; Inagaki, Naoki ; Tsutsui, Masato
出版情報: Journal of Pharmacological Sciences.  152  pp.76-85,  2023-06.  © 2023 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.
URL: http://hdl.handle.net/20.500.12000/0002019988
概要: Food allergies (FAs) are caused by a failure of the immune system to regulate oral tolerance (OT). The use of soap conta ining hydrolyzed wheat overrides acquired OT to wheat through skin exposure. However, in mouse models, the experimental OT is robust, suggesting that acquired OT to allergens prevents the development of FAs. We aimed to analyze the mechanisms and developed a mouse model of FA that overrides acquired OT via skin exposure. Three murine FA models (intraperitoneal [IP], epicutaneous [EC], and intradermal [ID]) were compared to evaluate if allergies to ovalbumin (OVA) that had been previously tolerated orally could be induced. In the ID model, OT was overridden, and allergic reactions of severe anaphylaxis were developed. To analyze this effect in the ID model, we measured the migration of dendritic cells (DCs) into lymph nodes. The induction of OT promoted the migration of CD103þ dermal DCs; moreover, repeated percutaneous doses of OVA for sensitization gradually increased the migration of CD11bþ dermal DCs. The difference in the proportion of regulatory T cells between ID-sensitized groups at the first ID injection disappeared at the tenth injection. Although OT was robust in the IP model, ID sensitization was found to override OT. 続きを見る
61.

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論文(リポジトリ)
Kondo, Tamiko
出版情報: ALAR Journal.  29  pp.13-28,  2023-10.  Action Learning, Action Research Association Ltd.
概要: Having received critical comments from academic journal reviewers, the Author reflects on herself and her practices, whi ch led to her thinking back to the start of her career as an Action Researcher and exploring ways to study herself and hence what it means to write an autoethnography. The exploration included a relevant literature review, which suggested to her that its writing process may inevitably lead authors to be engaged in the negotiation of their own identity, and an interview with a former colleague who has attempted to use autoethnography in her Action Research (AR) practice. The Author claims writing an autoethnography could help us negotiate our own identities through shuttling between them and through a dialogic relationship with ourselves, which is why it may be worth incorporating autoethnography into an AR practice. Most notably, the colleague’s word, which is that research made her strong, may mean everything to the Author. 続きを見る
62.

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論文(リポジトリ)
LUDIN, Samiullah ; FUKUDA, Tomoo
出版情報: 沖縄科学防災環境学会論文集 (River Eng.) — Journal of Science, Disaster Prevention, and Environmental Research (River Eng.).  8  pp.1-6,  2023.  Okinawa Society of Science, Disaster Prevention, and Environmental Engineering
概要: This study assessed the applicability of both linear and nonlinear tank models to predict runoff based on the delay time from rainfall to runoff, applying them to severe rain events in a small river with several square kilometers in the Okinawa Island. Suitable parameters for the linear and non-linear tank models were firstly assessed by applying them to three rain event, utilizing the genetic algorithm (GA) for parameter optimization. This optimization highlighted that both the linear and non-linear tank models reproduced well time variations of the water depths. Then, run-off predictions were performed by using average optimized parameters for each rain. For the 10-min runoff prediction, the linear tank model predicted well the water levels while the non-linear tank model, sensitive to small changes in its exponential parameter, was not able to predict well the water levels using average coefficient that differed from the optimized parameters for each rainfall event. 続きを見る
63.

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Duong, Quoc-Phi ; Wimmers, Anthony ; Herndon, Derrick ; Tan, Zhe-Min ; Zhuo, Jing-Yi ; Knaff, John ; Al Abdulsalam, Ibrahim ; Horinouchi, Takeshi ; Miyata, Ryota ; Avenas, Arthur
出版情報: Tropical Cyclone Research and Review.  12  pp.259-266,  2023-12.  © 2023 The Shanghai Typhoon Institute of China Meteorological Administration. Publishing services by Elsevier B.V. on behalf of KeAi Communication Co. Ltd.
概要: Here we explore the latest four years (2019–2022) of using satellite data to objectively analyze tropical cyclones (TC) and issue recommendations for improved analysis. We first discuss new methods of direct retrieval from SAR and geostationary imagers. Next, we survey some of the most prominent new techniques in AI and discuss their major capabilities (especially accuracy in nonlinear TC behavior, characterization of model uncertainty and creation of synthetic satellite imagery) and limitations (especially lack of transparency and limited amount of training data). We also identify concerns with biases and unlabeled uncertainties in the Best Track records as being a first-order limitation for further progress in objective methods. The article concludes with recommendations to improve future objective methods, especially in the area of more accurate and reliable training data sets. 続きを見る
64.

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論文(リポジトリ)
Takeshima, Masahiro ; Yoshizawa, Kazuhisa ; Enomoto, Minori ; Ogasawara, Masaya ; Kudo, Mizuki ; Itoh, Yu ; Ayabe, Naoko ; Takaesu, Yoshikazu ; Mishima, Kazuo
出版情報: Psychiatry and Clinical Neurosciences.  77  pp.264-272,  2022-12-29.  © 2022 The Authors. Psychiatry and Clinical Neurosciences published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Psychiatry and Neurology.
URL: http://hdl.handle.net/20.500.12000/0002019938
概要: Aim: The current study aimed to examine the effect of Japanese policies for appropriate hypnotics use and novel hypnotic s (e.g. melatonin receptor agonist and orexin receptor antagonist [ORA]) on long-term prescriptions of hypnotics. Methods: This retrospective study was conducted using a large-scale health insurance claims database. Among subscribers prescribed hypnotics at least once between April 2005 and March 2021, those prescribed hypnotics for the first time after being included in the database in three periods (period 1: April 2012–March 2013; period 2: April 2016–March 2017; and period 3: April 2018–March 2019) were eligible. These were set considering the timing of the 2014 and 2018 medical fee revisions (2014 for polypharmacy of three or more hypnotics, 2018 for long-term prescription of benzodiazepine receptor agonists for >12 months). The duration of consecutive prescriptions of hypnotics over 12 months was evaluated. Factors associated with short-term prescriptions of hypnotics were also investigated. Results: In total, 186 535 participants were newly prescribed hypnotics. The mean duration of prescriptions was 2.9 months, and 9.3% of participants were prescribed hypnotics for 12 months. Prescription periods were not associated with short-term prescriptions of hypnotics. ORA use was associated with short-term prescriptions of hypnotics (adjusted hazard ratio, 1.077 [95% confidence interval, 1.035–1.120]; P < 0.001), but melatonin receptor agonist use was not. Conclusion: Japanese policies had no statistically significant effect on long-term prescriptions of hypnotics. Although this study suggests initiating ORA for insomniacs as a candidate strategy to prevent long-term prescriptions of hypnotics, further research is necessary to draw conclusions. 続きを見る
65.

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論文(リポジトリ)
Kimoto, Kazufumi
出版情報: Ryukyu Mathematical Journal.  35  pp.1-11,  2022-12-28.  琉球大学理学部数理科学教室
概要: We show certain linear relations among Bernoulli numbers by using umbral calculus. As an application, we prove some congruence relations involving binomial coefficients and harmonic sums which appear in a certain supercongruence problem.
66.

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論文(リポジトリ)
Sudo, Takahiro
出版情報: Ryukyu Mathematical Journal.  35  pp.13-57,  2022-12-28.  琉球大学理学部数理科学教室
概要: We study noncommutative geometry (NG) by Connes, as a step forward to special understanding the theory as a memory keeping exercise back to the past for a return to the future.
67.

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論文(リポジトリ)
Takaesu, Yoshikazu ; Suzuki, Masahiro ; Margaret, Moline ; Kate, Pinner ; Inabe, Kanako ; Nishi, Yurie ; Kuriyama, Kenichi
出版情報: Clinical and Translational Science.  16  pp.581-592,  2022-12-23.  © 2022 The Authors. Clinical and Translational Science published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics.
URL: http://hdl.handle.net/20.500.12000/0002019937
概要: Discontinuing long-term pharmacotherapy for insomnia can result in rebound insomnia or withdrawal symptoms and suboptima l treatment. Post hoc analyses evaluated rebound insomnia and withdrawal symptoms among the subset of subjects from a phase III, 12-month, global, multicenter, randomized, double-blind, parallel-group study who completed 12 or 6 months of active treatment and follow-up period. Study E2006-G000- 303 (Study 303) included adults (N = 655) with subjective sleep-onset latency ≥30 min and/or subjective wake-after- sleep onset ≥60 min at least three times weekly during the 4 weeks before enrollment. Subjects were randomized 1:1:1 to lemborexant 5 mg (LEM5) or 10 mg (LEM10) or placebo for 6 months. Thereafter, for an additional 6 months, LEM5-and LEM10-treated subjects continued lemborexant and the placebo group was rerandomized 1:1 to LEM5 or LEM10. Month 12 was followed by abrupt discontinuation and a 2-week end-of- study follow-up. Using daily electronic sleep diaries, patients reported (subjective) sleep end points (sleep-onset latency, wake-after- sleep onset, sleep efficiency, and total sleep time). Withdrawal symptoms were assessed using the Tyrer Benzodiazepine Withdrawal Symptoms Questionnaire (T-BWSQ). Sleep outcome improvements with lemborexant at month 12 were generally maintained throughout the 2-week off-treatment period wherein <20% of subjects experienced significant worsening of insomnia symptoms versus screening. There was no evidence of withdrawal symptoms by T-BWSQ following lemborexant discontinuation. This analysis demonstrates rebound insomnia is unlikely to occur with lemborexant, and its effectiveness is maintained after abrupt discontinuation without placebo replacement following 6–12 months of treatment. Study Highlights WHAT IS THE CURRENT KNOWLEDGE ON THE TOPIC? Discontinuation of some hypnotic drugs can result in rebound insomnia or withdrawal. Rebound insomnia, which is usually temporary, may involve worsening of the insomnia originally being treated. WHAT QUESTION DID THIS STUDY ADDRESS? These post hoc analyses evaluated effects of treatment discontinuation in 6-to 12-month lemborexant-treated subjects (lemborexant 5 or 10 mg daily), followed by a 2-week follow-up period with no placebo replacement so clinicians could more easily interpret the safety data of lemborexant after discontinuation. These analyses also assessed the potential influence of lemborexant dose/treatment duration on the rate of sleep parameter worsening, along with what potential new adverse events might have emerged. WHAT DOES THIS STUDY ADD TO OUR KNOWLEDGE? This analysis demonstrates rebound insomnia is unlikely to occur with lemborexant, and its effectiveness is maintained after abrupt discontinuation following 6–12 months of treatment. HOW MIGHT THIS CHANGE CLINICAL PHARMACOLOGY OR TRANSLATIONAL SCIENCE? These findings suggest patients with insomnia can be treated with lemborexant long term without the fear of potential adverse effects of withdrawal and rebound insomnia reported for other insomnia pharmacotherapies. 続きを見る
68.

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論文(リポジトリ)
Takeshima, Masahiro ; Aoki, Yumi ; Ie, Kenya ; Katsumoto, Eiichi ; Tsuru, Eichi ; Tsuboi, Takashi ; Inada, Ken ; Kise, Morito ; Watanabe, Koichiro ; Mishima, Kazuo ; Takaesu, Yoshikazu
出版情報: International Journal of Environmental Research and Public Health.  19  2022-11-30.  © 2022 by the authors.Licensee MDPI, Basel, Switzerland.
URL: http://hdl.handle.net/20.500.12000/0002019912
概要: Long-term use of benzodiazepine receptor agonists (BZDs) may depend on clinicians’ BZD discontinuation strategies. We ai med to explore differences in strategies and difficulties with BZD discontinuation between psychiatrists and non-psychiatrists and to identify factors related to difficulties with BZD discontinuation. Japanese physicians affiliated with the Japan Primary Care Association, All Japan Hospital Association, and Japanese Association of Neuro-Psychiatric Clinics were surveyed on the following items: age group, specialty (psychiatric or otherwise), preferred time to start BZD reduction after improvement in symptoms, methods used to discontinue, difficulties regarding BZD discontinuation, and reasons for the difficulties. We obtained 962 responses from physicians (390 from non-psychiatrists and 572 from psychiatrists), of which 94.0% reported difficulty discontinuing BZDs. Non-psychiatrists had more difficulty with BZD discontinuation strategies, while psychiatrists had more difficulty with symptom recurrence/relapse and withdrawal symptoms. Psychiatrists used more candidate strategies in BZD reduction than non-psychiatrists but initiated BZD discontinuation after symptom improvement. Logistic regression analysis showed that psychosocial therapy was associated with less difficulty in BZD discontinuation (odds ratio, 0.438; 95% confidence interval, 0.204–0.942; p = 0.035). Educating physicians about psychosocial therapy may alleviate physicians’ difficulty in discontinuing BZDs and reduce long-term BZD prescriptions. 続きを見る
69.

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論文(リポジトリ)
Iida, Hitoshi ; Okada, Tsuyoshi ; Nemoto, Kiyotaka ; Hasegawa, Naomi ; Numata, Shusuke ; Ogasawara, Kazuyoshi ; Miura, Kenichiro ; Matsumoto, Junya ; Hori, Hikaru ; Iga, Jun-ichi ; Ichihashi, Kayo ; Hashimoto, Naoki ; Yamada, Hisashi ; Ohi, Kazutaka ; Yasui-Furukori, Norio ; Fukumoto, Kentaro ; Tsuboi, Takashi ; Usami, Masahide ; Furihata, Ryuji ; Takaesu, Yoshikazu ; Hishimoto, Akitoyo ; Muraoka, Hiroyuki ; Katsumoto, Eiichi ; Nagasawa, Tatsuya ; Ochi, Shinichiro ; Komatsu, Hiroshi ; Kikuchi, Saya ; Takeshima, Masahiro ; Onitsuka, Toshiaki ; Tamai, Shinichiro ; Kubota, Chika ; Inada, Ken ; Watanabe, Koichiro ; Kawasaki, Hiroaki ; Hashimoto, Ryota
出版情報: Neuropsychopharmacology Reports.  43  pp.23-32,  2022-11-28.  © 2022 The Authors. Neuropsychopharmacology Reports published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Society of Neuropsychopharmacology.
URL: http://hdl.handle.net/20.500.12000/0002019966
概要: To disseminate, educate, and validate psychiatric clinical practice guidelines, the Effectiveness of Guidelines for Dissemination and Education in Psychiatric Treatment (EGUIDE) project was launched in 2016. In this study, we investigated whether the web-based courses offered by this project would be as effective as the face-to- face courses. We analyzed and compared survey answers about overall participant satisfaction with the course and answers regarding clinical knowledge of schizophrenia and major depressive disorder between 170 participants who took the web-based courses in 2020 and 689 participants who took the face-to- face courses from 2016 to 2019. The web-based course participants completed the survey questions about satisfaction with the web-based courses. The web-based courses were conducted using a combination of web services to make it as similar as possible to the face-to- face courses. The degree of satisfaction assessed by the general evaluation of the web-based courses was higher than what was expected from the face-to- face courses. The degree of satisfaction was similar for the courses on schizophrenia and major depressive disorder. In addition, there were no significant differences in overall satisfaction and clinical knowledge between web-based and face-to- face courses. In conclusion, the web-based courses on clinical practice guidelines provided by the EGUIDE project were rated as more satisfying than the face-to- face course that the participants expected to take and no differences in the effectiveness of either course. The results suggest that, after the COVID-19 pandemic, it would be possible to disseminate this educational material more widely by adopting web-based courses additionally face-to- face courses. 続きを見る
70.

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論文(リポジトリ)
Aoyama, Hiroaki ; Yamagiwa, Kaishi ; Taira, Wataru ; Kon, Takeshi
出版情報: PLOS ONE.  17  2022-11-16.  © 2022 Aoyama et al.
URL: http://hdl.handle.net/20.500.12000/0002019995
概要: A unique historical architecture was created at Shuri Castle (Shuri-jo) in the Ryukyu Islands by its “Kawara” roof tiles . After the 13th and 14th centuries, Kawara tiles were introduced to the Ryukyu Islands from several regions, including China, Korea, and mainland Japan, and evolved shapes and patterns that are unique to this island region. However, the transition of some internal features, such as the chemical components and microstructure, had not been analyzed. This study used a multi-faceted approach for such internal data and non-destructive quantitative methods to propose a new perspective on the evolution of historical Ryukyuan Kawara. We analyzed two styles of Ryukyuan Kawara from the 13th to 15th centuries and found that the material processing and firing conditions of the two styles were very similar, even though it had been suggested that they had different origins. A quantitative analysis of tiles from the 16th to 19th centuries revealed a transition in color tone to red, leading to the modern traditional Ryukyuan tiles; traces of changes in firing conditions were also found along with this transition. Finally, the study revealed that the evolution of Ryukyuan Kawara consisted of changed factors, e.g. surface color, and unchanged factors, e.g. paste density. Previous archaeological studies mainly focused on changing external characteristics, such as form and pattern; however, our analysis showed that the internal features changed, while the elemental composition and paste density remained constant from the appearance of the roof tiles until the 19th century. We propose that this is related to different responses of individual factors to external stressors, such as the social context, which may be common to other archaeological artifacts as well. Our study provides a new perspective on the evolution of Ryukyuan Kawara and presents a different discussion of and methods for the chronological study of material culture. 続きを見る
71.

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論文(リポジトリ)
Zhou, Enping ; Kiuchi, Kenta ; Shibata, Masaru ; Tsokaros, Antonios ; Uryu, Koji
出版情報: PHYSICAL REVIEW D.  106  2022-11-15.  American Physical Society Sites
概要: We have evolved mergers of equal-mass binary quark stars, the total mass of which is close to the mass shedding limit of uniformly rotating configurations, in fully general relativistic hydrodynamic simulations, aimed at investigating the postmerger outcomes. In particular, we have identified the threshold mass for prompt black hole formation after the merger, by tracing the minimum lapse function as well as the amount of ejected material during the merger simulation. A semianalytical investigation based on the angular momentum contained in the merger remnant is also performed to verify the results. For the equation of state considered in this work, the maximum mass of cold spherical configurations is 2.10 M⊙, the threshold mass is found between 3.05 and 3.10 M⊙. This result is consistent (with a quantitative error smaller than 1%) with the universal relation derived from the numerical results of symmetric binary neutron star mergers. Contrary to the neutron star case, the threshold mass is close to the mass shedding limit of uniformly rotating quark star. Consequently, we have found that binary quark stars with total mass corresponding to the long-lived supramassive remnant for neutron star case, could experience collapse to black hole within several times dynamical timescale, making quark stars as exceptions of the commonly accepted postmerger scenarios for binary neutron star mergers.We have suggested explanation for both the similarity and the difference, between quark stars and neutron stars. 続きを見る
72.

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論文(リポジトリ)
Tsujii, Noa ; Okada, Takashi ; Usami, Masahide ; Kuwabara, Hidenori ; Fujita, Junichi ; Negoro, Hideki ; Iida, Junzo ; Aoki, Yumi RN ; Takaesu, Yoshikazu ; Saito, Takuya
出版情報: Psychiatry and Clinical Neurosciences Reports.  1  pp.57-,  2022-11-14.  © 2022 The Authors. Psychiatry and Clinical Neurosciences Reports published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Psychiatry and Neurology.
URL: http://hdl.handle.net/20.500.12000/0002019922
概要: Aim: Current clinical guidelines for attention‐deficit/hyperactivity disorder (ADHD) put shared decision making (SDM) at the center of care. However, there remain challenges in SDM in ADHD management, particularly regarding the decision to continue or discontinue medication after ADHD remission in adult patients. We aimed to develop a decision aid (DA) for adult patients with ADHD regarding the continuation or discontinuation of their ongoing ADHD medications after they have attained remission. Method: We systematically developed a DA according to the International Patient Decision Aid Standard (IPDAS). First, we created a DA prototype using the results of our previous systematic review and meta‐analysis that identified the consequences of continuing and discontinuing ADHD medications. Second, we administered a mixed‐method questionnaire (alpha acceptability testing) to adult patients with ADHD and healthcare providers to improve the DA prototype and develop it into a final version that is acceptable for clinical settings. 続きを見る
73.

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論文(リポジトリ)
Takaesu, Yoshikazu ; Yuta, Kanda ; Nagahama, Yu ; Shiroma, Ayano ; Ishii, Miho ; Hashimoto, Tasuku ; Watanabe, Koichiro
出版情報: Frontiers in Psychiatry.  13  2022-11-07.  © 2022 Takaesu, Kanda, Nagahama, Shiroma, Ishii, Hashimoto and Watanabe.
URL: http://hdl.handle.net/20.500.12000/0002019928
概要: Background: The delayed sleep-wake phase is commonly observed in major depressive disorder (MDD) and thought to be assoc iated with functional impairments. This study aimed to evaluate the relationship between the delayed sleep-wake phase, cognitive dysfunction, social dysfunction, and quality of life in patients with MDD. Methods: This cross-sectional design included 33 outpatients with MDD. Objective sleep-wake rhythm was assessed by actigraphy. Functional impairments were evaluated by the Japanese version of the Brief Assessment of Cognition in Schizophrenia (BACS-J), World Health Organization Disability Assessment Schedule (WHO-DAS), and Euro QOL 5 dimensions (EQ5D). Results: Actigraphic assessment of the delayed sleep-wake phase (midpoint of sleep) was significantly correlated with the composite score of the BACS-J (r = –0.489, p = 0.010), WHO-DAS score (r = 0.466, p = 0.014), and EQ5D score (r = 0.472, p = 0.013). No significant correlation was found between the other actigraphic sleep parameters (sleep latency, total sleep time, and sleep efficiency) and functional impairments. Conclusion: Our study’s results suggested that the delayed sleep-wake phase is associated with cognitive dysfunction, social dysfunction, and deteriorated quality of life in patients with MDD. Clinicians should pay attention to the sleep-wake rhythm in patients with MDD in clinical settings. 続きを見る
74.

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論文(リポジトリ)
Clos, Ruben ; Casado, Valenzuela Alicia
出版情報: 九州地区国立大学教育系・文系研究論文集 — The Joint Journal of the National Universities in Kyushu. Education and Humanities.  9  pp.14-,  2022-10-31.  九州地区国立大学間の連携事業に係る企画委員会リポジトリ部会
概要: 本研究は、日本の言語景観において、英語の権威がその他の外国語の立ち位置に対し影響を与えているかを考察する。具体的には、英語以外の外国語が日本語に翻訳される際、起点言語の特徴がそのまま反映されずに、英語の語句が部分的、又は全面的に使用されてい るかを観察する。とりわけ本研究では、スペイン語、ドイツ語、イタリア語、ロシア語、ポルトガル語の五つの言語が、日本における映画名の言語景観において、英語化しているかどうかを確認した。その手段として、これら五つの言語を元とする 338 本の映画を対象とし、それらの映画が日本で配給された際の題名を確認した。その結果、日本語への翻訳過程における外国語の英語化は、映画のジャンルにより、その程度に差異が存在することを明らかにした。特に、アクション、サスペンス、ホラー映画名の英語化率が高かった一方、ドラマ、ドキュメンタリー、コメディ映画名の場合は比較的に低かった。この故、アクション映画が少なかったイタリア語の映画名の英語化は稀であった一方、アクション映画が多かったスペ イン語やロシア語の映画名の英語化は顕著であった。
This study is focused on the situation of foreign languages in Japan apart from English, and on whether these are affected by the prestige of the English language in the country. More precisely, this study aims to look into cases where some foreign languages are partially or completely replaced by English when translated for Japanese audiences. For this purpose, we analysed 338 film titles from five languages (Spanish, German, Italian, Russian and Portuguese) and their resulting titles distributed in Japan. The results suggest that complete and partially anglicized versions of non-English titles are often used, affecting some film genres more than others. Action, suspense, and horror titles weremore prompt to anglicization in comparison to drama, documentaries, and comedies. Therefore, Spanish and Russian which contained the largest proportion of action films were overly more anglicized than Italian which had the least amount.
本論文は「九州地区国立大学教育系・文系研究論文集」Vol.9, No.1(2022年/10月)に査読を経て受理された。
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75.

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Fukazawa, Makoto ; 深澤, 真
出版情報: 九州地区国立大学教育系・文系研究論文集 — The Joint Journal of the National Universities in Kyushu. Education and Humanities.  9  pp.16-,  2022-10-31.  九州地区国立大学間の連携事業に係る企画委員会リポジトリ部会
URL: http://hdl.handle.net/20.500.12000/0002019536
概要: This study aims to investigate junior high school teachers’ perceptions of classroom language assessment in terms of the importance of assessment criteria, the utilization of assessment methods, and the difficulties in assessment following the introduction of the new Course of Study in 2021, and to compare the surveyed junior high school teachers’ perceptions with those of the elementary school teachers investigated in Fukazawa (2022). The results show that the assessment criteria, such as speaking interaction and students’ ability to think, make judgments, and expressing themselves, emphasized in the new national guidelines, are considered important by JHS teachers. Written and performance tests were the two language assessment methods most commonly used in junior high school, while observation was the most commonly used assessment method in elementary school. Enhancement of language assessment literacy and filling of the gap between elementary and junior high schools are suggested as the implications of this study.
本論文は「九州地区国立大学教育系・文系研究論文集」Vol.9, No.1(2022年/10月)に査読を経て受理された。
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76.

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Fukuyama, Michelle
出版情報: 九州地区国立大学教育系・文系研究論文集 — The Joint Journal of the National Universities in Kyushu. Education and Humanities.  9  pp.17-,  2022-10-31.  九州地区国立大学間の連携事業に係る企画委員会リポジトリ部会
URL: http://hdl.handle.net/20.500.12000/0002019539
概要: 本論文は「九州地区国立大学教育系・文系研究論文集」Vol.9, No.1(2022年/10月)に査読を経て受理された。
77.

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Maruki, Taku ; Utsumi, Tomohiro ; Takeshima, Masahiro ; Fujiwara, Yu ; Matsui, Marie ; Aoki, Yumi ; Toda, Hiroyuki ; Watanabe, Norio ; Watanabe, Koichiro ; Takaesu, Yoshikazu
出版情報: International Journal of Bipolar Disorders.  24  2022-10-21.  © The Author(s) 2022.
URL: http://hdl.handle.net/20.500.12000/0002019940
概要: Background: The efficacy and safety of adjunctive therapy are unclear in bipolar depression. In this systematic review a nd meta-analysis, we aimed to evaluate the efficacy and safety of second-generation antipsychotic, lamotrigine, lithium, or valproate therapy used in adjunction with lamotrigine, lithium, or valproate monotherapy in bipolar depression. A literature search of major electronic databases was conducted in February 2021, and all articles published until then were eligible. Two researchers independently screened relevant publications, extracted data, and evaluated methodological quality according to the Cochrane criteria. Results: Five studies met the inclusion criteria. The meta-analysis revealed significant differences in the following outcomes: (i) remission rates from depressive episodes (risk ratio [RR]: 1.23, 95% confidence interval [CI] 1.01–1.50, p = 0.04), (ii) improvement in depressive symptoms (standardized mean difference [SMD]: 0.21, 95% CI 0.09–0.34, p = 0.001), (iii) improvement in quality of life (SMD: 0.22, 95% CI 0.06–0.37, p = 0.005), and (iv) rate of adverse events during the study period (RR: 1.12, 95% CI 1.03–1.22, p = 0.008). There was no significant difference between adjunctive therapy and monotherapy in the emergence of suicide-related behaviors, dropout rate during the study period, or rate of manic switching. Conclusions: Our results suggest that adjunctive second-generation antipsychotics, lamotrigine, lithium, or valproate increase both the benefits and risks in patients with bipolar depression, although there is no significant difference in severe adverse events. Adjunctive therapy should be provided through shared decision-making while considering the patients’ condition in clinical settings. 続きを見る
78.

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Inada, Ken ; Fukumoto, Kentaro ; Hasegawa, Naomi ; Yasuda, Yuka ; Yamada, Hisashi ; Hori, Hikaru ; Ichihashi, Kayo ; Iida, Hitoshi ; Ohi, Kazutaka ; Muraoka, Hiroyuki ; Kodaka, Fumitoshi ; Ide, Kenta ; Hashimoto, Naoki ; Iga, Jun-ichi ; Ogasawara, Kazuyoshi ; Atake, Kiyokazu ; Takaesu, Yoshikazu ; Nagasawa, Tatsuya ; Komatsu, Hiroshi ; Okada, Tsuyoshi ; Furihata, Ryuji ; Kido, Mikio ; Kikuchi, Saya ; Kubota, Chika ; Makinodan, Manabu ; Ochi, Shinichiro ; Takeshima, Masahiro ; Yamagata, Hirotaka ; Matsumoto, Junya ; Miura, Kenichiro ; Usami, Masahide ; Kishimoto, Taishiro ; Onitsuka, Toshiaki ; Katsumoto, Eiichi ; Hishimoto, Akitoyo ; Numata, Shusuke ; Yasui-Furukori, Norio ; Watanabe, Koichiro ; Hashimoto, Ryota
出版情報: Neuropsychopharmacology Reports.  42  pp.502-509,  2022-10-18.  © 2022 The Authors. Neuropsychopharmacology Reports published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Society of Neuropsychopharmacology.
URL: http://hdl.handle.net/20.500.12000/0002019934
概要: Aims: The Guidelines for the Pharmacotherapy of Schizophrenia were established to improve the quality of medical care, and the EGUIDE project was conducted to train clinicians on guideline usage. A quality indicator (QI) was established to measure the prevalence of the guidelines, and a survey was conducted, which revealed a gap between the guidelines and actual clinical practice (evidence-practice- gap). The purpose of this study was to develop an individual fitness score (IFS) formula that expresses the degree to which prescribers adhere to the Guidelines for Pharmacological Therapy of Schizophrenia in a simple manner, and to determine the validity of this formula from a survey of the prescriptions of the EGUIDE project participants'. Methods: To establish appropriate scores, members discussed the proposed formula and then voted on them. The IFS formula developed was set up so that antipsychotic monotherapy would be given 100 points, with points deducted if concomitant or adjunctive antipsychotic medications were used, and a minimum score of 0. To validate this formula, prescriptions of hospitalized schizophrenic patients at admission and at discharge were scored and compared. Result: IFS points vary and ranged from 0 to100. The average pre-admission score for all subjects was 45.6, and the average score at discharge was 54, those were significantly higher during discharge. Conclusions: We developed an IFS formula, a tool to easily visualize the degree to which current prescriptions conform to the guidelines for the pharmacological treatment of schizophrenia. 続きを見る
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Takemura, Tomoyoshi ; Higa, Tatsuo ; Tanaka, Junichi
出版情報: 琉球大学理学部紀要.  pp.19-22,  2022-09-30.  琉球大学理学部
概要: An acetylenic alcohol 1 was isolated from a lipophilic extract of the stony coral Alveopora verrilliana collected at Komesu, Okinawa. The structure of compound 1 was elucidated to be a new member of polyacetylenes by analyzing spectroscopic data and by comparing the data with those of metabolites having similar structural moieties. 続きを見る
80.

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Koyama, Tomoyuki ; Higa, Tatsuo ; Tanaka, Junichi
出版情報: 琉球大学理学部紀要.  pp.23-29,  2022-09-30.  琉球大学理学部
概要: In our investigation on the secondary metabolites of Okinawan coral reef invertebrates, a series of bisabolene-class sesquiterpenoids were isolated from a sponge Halichondria sp. collected at Kerama Islands. After spectroscopic analyses of the isolates, new theonellin analogs 5-7 were elucidated in addition to the identification of known theonellins 1-4 and 8-9. The experimental evidence is provided in this note. 続きを見る
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Tanaka, Junichi ; Higa, Tatsuo
出版情報: 琉球大学理学部紀要.  pp.31-37,  2022-09-30.  琉球大学理学部
概要: A series of hennoxazoles (1, 4-6, 9-11) and miyakolide (8) were isolated from two specimens of the sponge Polyfibrospongia sp. Structures of hennoxazole E (5), hennoxazole A 4-acetate (6), hennoxazole E 4-acetate (10), and 3-dehydrohennoxazole D (11) will be discussed. In addition, the spectral data for hennoxazole F (6) and a diacetate of hennoxazole G (7) are reported in this note. 続きを見る
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Osada, Yohei ; 長田, 庸平
出版情報: Fauna Ryukyuana.  65  pp.1-2,  2022-09-16.  琉球大学資料館 (風樹館)
URL: http://hdl.handle.net/20.500.12000/0002019449
概要: Notocelia yakushimensis Kawabe isnewly recorded from the Yaeyama Islands. The specimen and male genitalia are shown. Eve n though emergence season of this species has been known as June, this individual was collected in October.
ミナミモッコクヒメハマキ ( 旧和名 : ヤクシマヒメハマキ ) は日本の固有種で , これまで本州 ( 和歌山県 ), 屋久島 , 奄美大島 , 沖縄島から知られていた . 寄主植物は , モッコク科のモッコクである . 大阪公立大学での標本調査において , 西表島産の本種の標本が確認されたので , ここに記録する . 八重山諸島では初記録と思われる . なお , 本種成虫は国内では 6 月に発生するとされているが , 本記録の個体は 10 月に採集されている . 八重山諸島では発生消長が異なる可能性がある .
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83.

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大澤, 正幸 ; Osawa, Masayuki ; 藤田, 喜久 ; Fujita, Yoshihisa
出版情報: Fauna Ryukyuana.  65  pp.41-51,  2022-09-16.  琉球大学資料館 (風樹館)
URL: http://hdl.handle.net/20.500.12000/0002019452
概要: Polyonyx haigae McNeil, 1968, a poorly known species of the porcellanid genus Polyonyx Stimpson, 1858, is recorded for t he first time from Japanese waters based on material collected from Oura Bay in Okinawa Island of the Ryukyu Islands, southwestern Japan. This represents the third record of the species and extends the distribution range more northward and eastward than the previous record from the Nansha Islands in the South China Sea. The present two specimens occurred as a heterosexual pair in a tube of an unidentified species of the polychaete genus Chaetopterus Cuvier, 1830. This symbiotic habit has been also known for many of the other species of the P. sinensis group to which P. haigae belongs.
沖縄島の大浦湾から採集された標本に基づき , ヤワゲヤドリカニダマシ ( 新称 ) Polyonyx haigae McNeil, 1968 を報告し , 詳細に記載した . 沖縄島の標本は , 本種の日本沿岸からの初記録 , そして西太平洋域からの 3 番目の記録となる . 本種は , ツバサゴカイ属 Chaetopterus の未同定種の棲管中から雌雄 1 対で得られた . ツバサゴカイ属の種との共生は , 本種が属する P. sinensis 種群の他の多くの種においても知られている .
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Yamazaki, Daishi ; 山崎, 大志
出版情報: Fauna Ryukyuana.  65  pp.75-81,  2022-09-16.  琉球大学資料館 (風樹館)
URL: http://hdl.handle.net/20.500.12000/0002019456
概要: The present study reports the first record of the genus Japonia Gould, 1859 from Kikaijima Island, the Amami Gunto Islan ds, Japan. The Japonia species found in Kikaijima Island is identified as J. tokunoshimana Pilsbry & Y. Hirase, 1904 based on the presence of two rows of petal-like and spreading periostracal hairs on the shell. Although many of the hairs of the present specimen of J. tokunoshimana have unfortunately fallen out, their relatively short length suggests that the Kikaijima specimen is J. t. tokunoshimana, not J. t. okinoerabuensis Minato, 1974.
奄美群島喜界島に産するヤマトガイ属 Japonia の初記録を報告する . 琉球列島における本属の既知種はそれぞれ殻皮毛に関する特徴で区別されている . 喜界島産の本報告個体は,2 列かつ広い花弁状の殻皮毛をもつことから種トクノシマヤマトガイ J. tokunoshimana Pilsbry & Y. Hirase, 1904 と同定された . さらにトクノシマヤマトガイは殻皮毛の長さから基亜種 J. tokunoshimana tokunoshimana もしくはオキノエラブヤマトガイ J. tokunoshimana okinoerabuensis Minato, 1974 に分かたれている . 本報告個体の殻皮毛の多くは脱落しているが残存するものは比較的短いことから , オキノエラブヤマトガイではなくトクノシマヤマトガイと同定した . 本属の多くは希産種であり , 絶滅が心配されている一方 , 十分な分類学的検討を欠く . 琉球列島における分布記録の集積に加え , 今後の詳細な形態的・遺伝的解析が求められる .
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85.

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Tanaka, Yuetsu ; Tanaka, Reiko ; Imaizumi, Naoki ; Mizuguchi, Mariko ; Takahashi, Yoshiaki ; Hayashi, Masaki ; Miyagi, Takashi ; Uchihara, Junnosuke ; Ohshiro, Kazuiku ; Masuzaki, Hiroaki ; Fukushima, Takuya
出版情報: Frontiers in Immunology.  13  2022-09-13.  © 2022 Tanaka, Tanaka, Imaizumi, Mizuguchi, Takahashi, Hayashi, Miyagi, Uchihara, Ohshiro, Masuzaki and Fukushima.
URL: http://hdl.handle.net/20.500.12000/0002019903
概要: Human T-cell leukemia virus type-1 (HTLV-1) establishes a long-term persistent infection in humans and causes malignant T-cell leukemia, adult T-cell leukemia (ATL). HTLV-1-specific cytotoxic T lymphocytes have been suggested to play a major role in the immunosurveillance of HTLV-1-infected T cells. However, it remains unclear whether HTLV-1-specific functional antibodies are also involved in the host defense. To explore the role of antibodies in the course of HTLV-1 infection, we quantitated HTLV-1-specific neutralizing and antibody-dependent cellular cytotoxicity (ADCC)-inducing antibody levels in plasma from asymptomatic carriers (ACs) and ATL patients. The levels of neutralizing antibodies, as determined by a syncytium inhibition assay, were significantly lower in acute and chronic ATL patients than in ACs. The levels of ADCC-inducing activity were tested using an autologous pair of HTLV-1-producing cells and cultured natural killer (NK) cells, which showed that the ADCC-inducing activity of IgG at a concentration of 100 μg/ml was comparable between ACs and acute ATL patients. The anti-gp46 antibody IgG levels, determined by ELISA, correlated with those of the neutralizing and ADCC-inducing antibodies. In contrast, the proviral loads did not correlate with any of these antibody levels. NK cells and a monoclonal anti-gp46 antibody reduced the number of HTLV-1 Tax-expressing cells in cultured peripheral blood mononuclear cells from patients with aggressive ATL. These results suggest a protective role for HTLV-1 neutralizing and ADCC-inducing antibodies during the course of HTLV-1 infection. 続きを見る
86.

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Saito, Hiroki ; Tomita, Asami ; Yoshida, Tomofumi ; Nakamura, Mitsuru ; Suzuki, Taro ; Ikeda, Akihiro ; Kato, Takahiro ; Nakajima, Yasunori ; Tanimoto, Ryo ; Tani, Toshio ; Hayashi, Nagao ; Hirabayashi, Hideyuki ; Ando, Ikuo ; Fukuta, Yoshimichi
出版情報: PhytoFrontiers™.  2  pp.230-241,  2022-09-08.  © 2022 The Author(s).
URL: http://hdl.handle.net/20.500.12000/0002019917
概要: Seven near isogenic lines (NILs) for six partial blast-resistance genes—Pi35,pi21, Pi37(t)(Pi37-KRIL17), Pb1, and Pi34 ( two: Pi34-Chubu32 and Pi34-Chugoku40, originating from different Japonica Group rice lines, ‘Chubu 32’ and ‘Chugoku 40’, respectively)—and one quantitative trait locus (QTL), PiPHL9, derived from Japonica Group line ‘Hokkai PL9’,were developed in rice (Oryza sativa L.).These NILs have the genetic background of an Indica Group susceptible line ‘US-2’, which does not harbor complete resistance genes and can clarify the effects of partial resistance genes and the QTL. These NILs and US-2 were used to determine the effects of the partial resistance genes and the QTL based on the results of an inoculation test for leaf blast using international standard differential blast isolates in the young seedling stage and a natural infection test in the mature stage after heading at a blast field.The NILs produced mainly moderate reactions in the inoculation test and rarely exhibited “resistant” and “susceptible” reactions. Each of the partial resistance genes and the QTL had different effects in panicle blast. Two genes, Pi35 and Pb1, were the most effective with respect to resistance, followed by Pi37-KRIL17. Pi34-Chugoku40 was the weakest. The effects of pi21, Pi34-Chubu32, and PiPHL9 varied among cultivation seasons and could be easily affected by environmental conditions. This is the first report clarifying the effects of partial resistance genes without the major complete genes, which will be helpful for advanced genetic and pathological studies and as a source of genes for rice breeding. 続きを見る
87.

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Takaesu, Yoshikazu ; Aoki, Yumi ; Tomo, Yui ; Tsuboi, Takashi ; Ishii, Miho ; Imamura, Yayoi ; Tachimori, Hisateru ; Watanabe, Koichiro
出版情報: Frontiers in Psychiatry.  13  2022-08-12.  © 2022 Takaesu, Aoki, Tomo, Tsuboi, Ishii, Imamura, Tachimori and Watanabe.
URL: http://hdl.handle.net/20.500.12000/0002019948
概要: Background: Although shared treatment decision-making with patients requires attention, it is not widely implemented, pa rticularly in the field of psychiatry. The aim of this study was to assess whether a shared decision-making (SDM) training program for clinicians based on the major depressive disorder (MDD) guidelines improved the perceived involvement of the decision process for patients with MDD. Methods: A multi-center cluster-randomized controlled intervention of a clinician training program based on the Japanese MDD guidelines using related decision aids compared to usual care was conducted among 56 clinicians from 23 institutions. A total of 124 patients with MDD were enrolled in this study. The primary outcomes were the scores of the Shared Decision Making-Questionnaire-9 (SDM-Q-9) and Decision Conflict Scale (DCS) after the first visit to the outpatient clinics. The secondary outcomes were patients’ satisfaction, quality of life, trust in clinicians, and depressive symptoms. Additionally, we evaluated all the observed outcomes at the first and third months of follow-up. Results: The scores of the SDM-Q-9 in the SDM training program group were significantly higher than those in the control group at the first visit. However, no significant difference in the DCS scores was found between the two groups. There was no intervention effect for secondary outcomes and the outcomes at the first- and third-month follow-up visits. Conclusion: The clinician training program based on the Japanese MDD guidelines can be useful for implementation of SDM. Additional research is needed to confirm the efficacy of this SDM training program. 続きを見る
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Miyagi, Riko ; Nakachi, Sawako ; Tamaki, Yasutaro ; Doi, Mototsugu ; Nakajima, Tomo ; Tomori, Shohei ; Hanashiro, Taeko ; Tamaki, Keita ; Morichika, Kazuho ; Nishi, Yukiko ; Morishima, Satoko ; Fukushima, Takuya ; Masuzaki, Hiroaki
出版情報: Modern Rheumatology Case Reports.  7  pp.102-107,  2022-08-11.  Oxford University Press
概要: Clinically amyopathic dermatomyositis (CADM) lacks muscle symptoms, associated with rapidly progressive interstitial lun g disease. Anti-melanoma differentiation-associated gene 5 (MDA-5) antibody has been identified as a disease-labelling autoantibody. We report two cases of CADM manifested after the allogeneic haematopoietic stem cell transplantation (allo-HSCT)—Case 1: a 56-year-old man with acute leukaemia received the allo-HSCT and Case 2: a 45-year-old female patient with lymphoma received the allo-HSCT. She received donor lymphocyte infusion because of a post-transplant relapse. After allo-HSCT or donor lymphocyte infusion, Gottron papules emerged, and both patients were diagnosed as CADM based on dermatological findings coupled with the positivity of anti-MDA-5 antibody, accompanied by interstitial shadows consistent with ILD on chest computed tomography. Case 2 was initially diagnosed as a kind of chronic graft versus host disease. Their symptoms were improved by the combination of immunosuppressive agents with a concomitant decrease in anti-MDA-5 antibody levels. For Case 2, rituximab was subsequently started for relapse of lymphoma, resulting in a substantial decrease in the level of anti-MDA-5 antibody and improvement in rash and ILD. Our cases raise a possibility that CADM emerges after the HSCT, highlighting the importance of early diagnosis to avoid fated progression into ILD. 続きを見る
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Ogasawara, Masaya ; Takeshima, Masahiro ; Esaki, Yuichi ; Kaneko, Yoshiyuki ; Utsumi, Tomohiro ; Aoki, Yumi ; Watanabe, Norio ; Suzuki, Masahiro ; Takaesu, Yoshikazu
出版情報: Neuropsychopharmacology Reports.  42  pp.410-420,  2022-07-20.  © 2022 The Authors. Neuropsychopharmacology Reports published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Society of Neuropsychopharmacology.
URL: http://hdl.handle.net/20.500.12000/0002019920
概要: Aim: Pharmacological treatments recommended for bipolar depression are inconsistent across guidelines. We compared the e fficacy and safety of antipsychotics and mood stabilizers for bipolar depression. Methods: A systemic review and meta-analysis of randomized controlled trials comparing antipsychotics and mood stabilizers for bipolar depression was conducted based on a literature search of major electronic databases. Results: Three studies comparing quetiapine with lithium were identified and analyzed; no other antipsychotic-mood stabilizer combinations were found. The meta-analysis revealed no significant differences between quetiapine and lithium for the following outcomes: (1) remission from depressive episodes (risk ratio [RR]: 1.80, 95% CI: 0.51-6.40, P = 0.36), (2) changes in depressive symptom (standardized mean difference: −0.22, 95% CI: −0.52-0.08, P = 0.15), (3) changes in social function (standardized mean difference: −0.00, 95% CI: −0.19-0.18, P = 0.98), (4) suicide-related events (odds ratio [OR]: 2.35, 95% CI: 0.40-13.65, P = 0.34), (5) severe adverse events (OR: 1.63, 95% CI: 0.51-5.20, P = 0.41), (6) dropouts due to adverse events (RR: 1.19, 95% CI: 0.76-1.87, P = 0.45, 7) dropout for any reasons (RR: 0.95, 95% CI: 0.74-1.22, P = 0.70). Conclusion: Although this study found no differences in the efficacy and safety of quetiapine and lithium for bipolar depression, a comprehensive comparison of antipsychotics and mood stabilizers was not performed. Further studies are needed to clarify which of these, not just quetiapine and lithium, is more useful for bipolar depression. 続きを見る
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Saeki, Hidehisa ; Kanai, Yasumasa ; Murotani, Kenta ; Ito, Kei ; Miyagi, Takuya ; Takahashi, Hidetoshi ; Tada, Yayoi ; Higashiyama, Mari ; Hashimoto, Yuki ; Kitabayashi, Hiroki ; Imafuku, Shinichi
出版情報: The Journal of Dermatology.  49  pp.970-978,  2022-07-20.  © 2022 The Authors. The Journal of Dermatology published by John Wiley & Sons Australia, Ltd on behalf of Japanese Dermatological Association.
URL: http://hdl.handle.net/20.500.12000/0002019976
概要: Psoriasis poses a substantial economic burden by reducing the work productivity of affected patients. We aimed to evalua te the negative impact of plaque psoriasis on work productivity and effectiveness of brodalumab in improving work productivity impairment in real-life employed patients. This analysis was conducted in employed patients from ProLOGUE, an open-label, multicenter, prospective cohort study (Japan Registry of Clinical Trials identifier: jRCTs031180037). Outcomes included association of Work Productivity and Activity Impairment-Psoriasis (WPAI-PSO) domain scores with scores from various patient-reported outcome measures or Psoriasis Area and Severity Index (PASI) scores at baseline. Change from baseline in WPAI-PSO domain scores following brodalumab treatment was also evaluated. Of the 73 patients enrolled, 51, 48, and 40 patients were considered employed at baseline, Week 12, and Week 48 of brodalumab treatment, respectively. In the model adjusted by age and sex, the work productivity loss score correlated with the Dermatology Life Quality Index (DLQI), itch Numeric Rating Scale (NRS), Patient Health Questionnaire-8 (PHQ-8), and skin pain NRS scores (partial Spearman correlation coefficient [ρ] = 0.608, 0.510, 0.461, and 0.424, respectively); presenteeism score correlated with the DLQI, itch NRS, and skin pain NRS scores (ρ = 0.568, 0.500, and 0.403, respectively); and activity impairment score correlated with the DLQI and PHQ-8 scores (ρ = 0.530 and 0.414, respectively). None of the WPAI-PSO domain scores correlated with the PASI score. All WPAI-PSO domain scores (except absenteeism) significantly reduced from baseline to Weeks 12 (p < 0.0001) and 48 (p < 0.001) with brodalumab treatment. In conclusion, work productivity impairment in psoriasis was associated with various subjective symptoms that can be captured using patient-reported outcome measures. Brodalumab treatment improved work productivity in real-life employed patients with plaque psoriasis. 続きを見る
91.

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論文(リポジトリ)
Shimajiri, Tomoyuki ; Otaki M. Joji
出版情報: Insects.  13  2022-07-19.  MDPI
URL: http://hdl.handle.net/20.500.12000/0002019617
概要: Butterfly wing color patterns are sensitive to environmental stress, such as temperature shock, and this phenotypic plasticity plays an important role in color pattern evolution. However, the potential contributions of phenotypic plasticity to mimicry evolution have not been evaluated. Here, we focused on the swallowtail butterfly Papilio polytes, which has nonmimetic and mimetic forms in females, to examine its plastic phenotypes. In the nonmimetic form, medial white spots and submarginal reddish spots in the ventral hindwings were enlarged by cold shock but were mostly reduced in size by heat shock. These temperature-shock-induced color pattern modifications were partly similar to mimetic color patterns, and nonmimetic females were more sensitive than males and mimetic females. Unexpectedly, injection of tungstate, a known modification inducer in nymphalid and lycaenid butterflies, did not induce any modification, but fluorescent brightener 28, another inducer discovered recently, induced unique modifications. These results suggest that phenotypic plasticity in nonmimetic females might have provided a basis of natural selection for mimetic color patterns during evolution. 続きを見る
92.

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論文(リポジトリ)
Aoki, Yumi ; Takaesu, Yoshikazu ; Baba, Hajime ; Iga, Jun-ichi ; Hori, Hikaru ; Inoue, Takeshi ; Mishima, Kazuo ; Tajika, Aran ; Kato, Masaki
出版情報: Neuropsychopharmacology Reports.  42  pp.306-314,  2022-07-01.  © 2022 The Authors. Neuropsychopharmacology Reports published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Society of Neuropsychopharmacology.
URL: http://hdl.handle.net/20.500.12000/0002019932
概要: Aim: While evidence-based antidepressant treatment is available for major depressive disorder, standard approaches for discontinuation of antidepressants after remission have not yet been established. Decision aids are structured clinical tools that facilitate shared decision-making between patients and healthcare providers. This study aimed to describe the development process and acceptability of decision aids for major depressive disorder following discontinuation of antidepressant treatment after remission. Methods: We systematically developed a decision aids according to the International Patient Decision Aid Standards. First, a decision aids prototype was created using the results of a systematic review and meta-analysis previously conducted to identify the consequences of continuing and discontinuing antidepressant treatment. Second, a mixed-methods questionnaire (alpha acceptability testing) was administered to patients and healthcare providers to improve the decision aids prototype and develop it into a final version acceptable for clinical settings. Results: Our decision aids consisted of a description of major depressive disorder, the option to continue or discontinue antidepressant treatment, the advantages and disadvantages of each option, the consequences of each option, and value clarification exercises for each option. The patients (n = 22) reported that the decision aids had acceptable language (91%), adequate information (91%), and a well-balanced presentation (95%). Healthcare providers (n = 20) provided favorable feedback. The final decision aids fulfilled all six International Patient Decision Aid Standards qualifying criteria. Conclusion: We successfully developed a decision aids for discontinuation of antidepressant treatment after remission, which could be used during the shared decision-making process. Further studies are needed to verify 続きを見る
93.

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論文(リポジトリ)
Takeshima, Masahiro ; Enomoto, Minori ; Ogasawara, Masaya ; Kudo, Mizuki ; Itoh, Yu ; Yoshizawa, Kazuhisa ; Fujiwara, Dai ; Takaesu, Yoshikazu ; Mishima, Kazuo
出版情報: Psychiatry and Clinical Neurosciences.  76  pp.475-477,  2022-06-02.  © 2022 The Authors.Psychiatry and Clinical Neurosciences published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Psychiatry and Neurology.
URL: http://hdl.handle.net/20.500.12000/0002019914
94.

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論文(リポジトリ)
Futenma, Kunihiro ; Takaesu, Yoshikazu ; Nakamura, Masaki ; Hayashida, Kenichi ; Takeuchi, Noboru ; Inoue, Yuichi
出版情報: International Journal of Environmental Research and Public Health.  19  2022-05-22.  MDPI
URL: http://hdl.handle.net/20.500.12000/0002019345
概要: Narcolepsy types 1 (NT1) and 2 (NT2) and idiopathic hypersomnia (IH) are thought to be a disease continuum known as narc olepsy spectrum disorders (NSDs). This study aimed to assess the prevalence of and factors associated with metabolic-syndrome-related disorders (MRDs) among patients with NSD. Japanese patients with NSD (NT1, n = 94; NT2, n = 83; and IH, n = 57) aged ≥35 years were enrolled in this cross-sectional study. MRD was defined as having at least one of the following conditions: hypertension, diabetes, or dyslipidemia. Demographic variables and MRD incidence were compared among patients in the respective NSD categories. Multivariate logistic regression analysis was used to investigate the factors associated with MRDs. Patients with NT1 had a higher body mass index (BMI) and incidence of MRD than that had by those with NT2 or IH. Age, BMI, and the presence of OSA were significantly associated with the incidence of MRD in NSDs. Age and BMI in NT1, BMI and human leukocyte antigen (HLA)-DQB1*06:02 positivity in NT2, and only age in IH were factors associated with the incidence of MRD. Obesity should be carefully monitored in narcolepsy; however, NT2 with HLA-DQB1*06:02 positive should be followed up for the development of MRD even without obesity. 続きを見る
95.

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論文(リポジトリ)
Hori, Hikaru ; Yasui-Furukori, Norio ; Hasegawa, Naomi ; Iga, Jun-ichi ; Ochi, Shinichiro ; Ichihashi, Kayo ; Furihata, Ryuji ; Kyo, Yoshitaka ; Takaesu, Yoshikazu ; Tsuboi, Takashi ; Kodaka, Fumitoshi ; Onitsuka, Toshiaki ; Okada, Tsuyoshi ; Murata, Atsunobu ; Kashiwagi, Hiroko ; Iida, Hitoshi ; Hashimoto, Naoki ; Ohi, Kazutaka ; Yamada, Hisashi ; Ogasawara, Kazuyoshi ; Yasuda, Yuka ; Muraoka, Hiroyuki ; Usami, Masahide ; Numata, Shusuke ; Takeshima, Masahiro ; Yamagata, Hirotaka ; Nagasawa, Tatsuya ; Tagata, Hiromi ; Makinodan, Manabu ; Kido, Mikio ; Katsumoto, Eiichi ; Komatsu, Hiroshi ; Matsumoto, Junya ; Kubota, Chika ; Miura, Kenichiro ; Hishimoto, Akitoyo ; Watanabe, Koichiro ; Inada, Ken ; Kawasaki, Hiroaki ; Hashimoto, Ryota
出版情報: Frontiers in Psychiatry.  13  2022-05-17.  © 2022 Hori, Yasui-Furukori, Hasegawa, Iga, Ochi, Ichihashi, Furihata, Kyo, Takaesu, Tsuboi, Kodaka, Onitsuka, Okada, Murata, Kashiwagi, Iida, Hashimoto, Ohi, Yamada, Ogasawara, Yasuda, Muraoka, Usami, Numata, Takeshima, Yamagata, Nagasawa, Tagata, Makinodan, Kido, Katsumoto, Komatsu, Matsumoto, Kubota, Miura, Hishimoto, Watanabe, Inada, Kawasaki and Hashimoto.
URL: http://hdl.handle.net/20.500.12000/0002019962
概要: In several clinical guidelines for schizophrenia, long-term use of anticholinergic drugs is not recommended. We investig ated the characteristics of the use of anticholinergics in patients with schizophrenia by considering psychotropic prescription patterns and differences among hospitals. A cross-sectional, retrospective prescription survey at the time of discharge was conducted on 2027 patients with schizophrenia from 69 Japanese hospitals. We examined the relations among psychotropic drug prescriptions regarding anticholinergic prescription. We divided the hospitals into three groups— low rate group (LG), medium rate group (MG), and high rate group (HG)—according to their anticholinergic prescription rates, and analyzed the relationship between anticholinergic prescription rates and antipsychotic prescription. Anticholinergic drugs were prescribed to 618 patients (30.5%), and the prescription rates were significantly higher for high antipsychotic doses, antipsychotic polypharmacy, and first-generation antipsychotics (FGAs) use. The anticholinergic prescription rate varied considerably among hospitals, ranging from 0 to 66.7%, and it was significantly higher in patients with antipsychotic monotherapy, antipsychotic polypharmacy, and normal and high doses of antipsychotics in HG than in those LG and MG. The anticholinergics prescription rate in patients with second-generation antipsychotic monotherapy in HG was also significantly higher than in those LG and MG; however, the difference was no longer significant in patients with FGA monotherapy. Conclusively, in addition to high antipsychotic doses, antipsychotic polypharmacy, and FGA use, hospital characteristics influence the prescribing of anticholinergic drugs. 続きを見る
96.

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論文(リポジトリ)
Kinjo, Takeshi ; Toma, Hiromu ; Fujita, Jiro
出版情報: The American Journal of Tropical Medicine and Hygiene.  106  pp.1583-1584,  2022-05-16.  © 2022 by The American Society of Tropical Medicine and Hygiene
URL: http://hdl.handle.net/20.500.12000/0002019907
97.

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論文(リポジトリ)
Sekiguchi, Hiroshi ; Takeuchi, Rie ; Sato, Yoko ; Matsumoto, Tsuyoshi ; Kobayashi, Jun ; Umemura, Takehiro
出版情報: International Journal of Environmental Research and Public Health.  19  2022-05-06.  MDPI
URL: http://hdl.handle.net/20.500.12000/0002019664
概要: An earthquake with a magnitude of 8 or 9 is predicted to occur near the Ryukyu Islands in Japan, for which the Okinawa Prefecture is preparing countermeasures. Evacuating people to a safe shelter within the tsunami arrival time is a crucial countermeasure. This study aims to understand the vulnerabilities of patients with chronic respiratory diseases in southern parts of Okinawa during a tsunami evacuation, thereby calculating evacuation distance of vulnerable patients and creating individual evacuation plans. Data for chronic respiratory patients obtained in July 2021 from the hospitals in Okinawa Prefecture include age, gender, diagnosis, residence, nearest tsunami shelter, oxygen flow at rest and walking, and maximum walking distance for 6 min based on a 6-min walk test. A quantum geographic information system was used for mapping the data. The survival potential of patients with chronic respiratory disease was evaluated by using a tsunami inundation depth of one meter and the distance within which an evacuation can be performed until the first tsunami wave reaches the nearest evacuation shelter. Results revealed a low survival potential for respiratory disease patients under the current tsunami evacuation plan. The study suggests creating an individual evacuation plan for vulnerable patients involving families and medical staff and then conducting a drill for improving the plan. 続きを見る
98.

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論文(リポジトリ)
Uesato, Yasunori ; Kawamata, Futoshi ; Ishino, Shinichiro ; Ono, Shinichiro ; Tamashiro, Koichi ; Koyama, Hirofumi ; Takatsuki, Mitsuhisa
出版情報: J Gastrointest Oncol.  13  pp.1384-1394,  2022-05-06.  © Journal of Gastrointestinal Oncology.
概要: Background: The human chorionic gonadotropin free beta-subunit (hCGβ) is ectopically produced in various epithelial canc ers and is associated with poor prognoses. However, its molecular mechanism remains unclear. In this study, we examined the biological role of hCGβ in pancreatic cancer progression. Methods: Tissue specimens of 30 patients with pancreatic cancer were examined immunohistochemically to investigate the relationship between hCGβ expression and clinicopathological features. We also evaluated the molecular effects of hCGβ-downregulated pancreatic cell lines. Results: Total of 21 cases were positive for immunostaining, and 17 of 25 metastatic lymph nodes were positive. hCGβ expression levels were correlated with pancreatic cancer T and N factors. hCGβ expression was significantly associated with poor overall and recurrence-free survival (P<0.001). In a multivariate analysis, hCGβ expression was independently associated with overall survival (HR 14.0; 95% CI: 1.5–130; P=0.019). The proliferative, invasive, and migratory abilities of hCGβ-downregulated cell lines were reduced compared with the control cell lines. Moreover, downregulation of hCGβ reduced vimentin, slug, and α-smooth muscle actin expression and increased E-cadherin expression. Conclusions: hCGβ expression is related to cancer progression and poor prognoses via epithelial mesenchymal transition. hCGβ is a potential prognostic marker and molecular target in pancreatic cancer. Keywords: Human chorionic gonadotropin free beta; pancreatic cancer; epithelial mesenchymal transition; transforming growth factor; pancreatic cell lines 続きを見る
99.

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論文(リポジトリ)
Deng, Yange ; Fujinari, Hiroaki ; Yai, Hikari ; Shimada, Kojiro ; Miyazaki, Yuzo ; Tachibana, Eri ; Deshmukh, K. Dhananjay ; Kawamura, Kimitaka ; Nakayama, Tomoki ; Tatsuta, Shiori ; Cai, Mingfu ; Xu, Hanbing ; Li, Fei ; Tan, Haobo ; Ohata, Sho ; Kondo, Yutaka ; Takami, Akinori ; Hatakeyama, Shiro ; Mochida, Michihiro
出版情報: Atmospheric Chemistry and Physics.  22  pp.5515-5533,  2022-05-02.  European Geosciences Union — Copernicus Publications
URL: http://hdl.handle.net/20.500.12000/0002017926
概要: Filter-based offline analysis of atmospheric aerosol hygroscopicity coupled to composition analysis provides information complementary to that obtained from online analysis. However, its application itself and comparison to online analysis have remained limited to date. In this study, daily submicrometer aerosol particles (PM0.95, 50 % cutoff diameter 0.95 µm) were collected onto quartz fiber filters on Okinawa Island, a receptor of East Asian outflow, in the autumn of 2015. The chemical composition of water-soluble matter (WSM) in PM0.95, PM0.95 itself, and their respective hygroscopicities were characterized through the offline use of an aerosol mass spectrometer and a hygroscopicity tandem differential mobility analyzer. Thereafter, results were compared with those obtained from online analyses. Sulfate dominated the WSM mass (59 %), followed by water-soluble organic matter (WSOM, 20 %) and ammonium (13 %). WSOM accounted for most (91 %) of the mass of extracted organic matter (EOM) and the atomic O-to-C ratios (O : C) of WSOM and EOM were high (mean ± standard deviation were 0.84 ± 0.08 and 0.78 ± 0.08, respectively), both of which indicate highly aged characteristics of the observed aerosol. The hygroscopic growth curves showed clear hysteresis for most samples. At 85 % relative humidity (RH), the calculated hygroscopicity parameter κ values of the WSM (κWSM), WSOM, EOM, andPM0.95 (κPM0.95 ) were 0.50 ± 0.03, 0.22 ± 0.12, 0.20 ± 0.11, and 0.47 ± 0.03, respectively. An analysis using the thermodynamic Extended Aerosol Inorganics Model (E-AIM) shows, on average, that inorganic salts and WSOM contributed 88 % and 12 %, respectively, of the κWSM (or κPM0.95 ). High similarities were found between offline and online analysis for chemical compositions that are related to particle hygroscopicity (the mass fractions and O : C of organics and the degree of neutralization) and also for aerosol hygroscopicity. As possible factors governing the variation in κWSM, the influences of WSOM abundance and the neutralization of inorganic salts were assessed. At high RH (70 %–90 %), the hygroscopicity of WSM and PM0.95 was affected considerably by the presence of organic components; at low RH (20 %–50 %), the degree of neutralization could be important.This study not only characterized aerosol hygroscopicity at the receptor site of East Asian outflow but also shows that offline hygroscopicity analysis is an appropriate method, at least for aerosols of the studied type. The results encourage further applications to other environments and to more in-depth hygroscopicity analysis, in particular for organic fractions. 続きを見る
100.

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論文(リポジトリ)
Morita, Akari ; Sakauchi, Ko ; Taira, Wataru ; Otaki, M. Joji
出版情報: Life.  12  2022-04-20.  MDPI
URL: http://hdl.handle.net/20.500.12000/0002019615
概要: Biological effects of the Fukushima nuclear accident have been reported in various organisms, including the pale grass blue butterfly Zizeeria maha and its host plant Oxalis corniculata. This plant upregulates various secondary metabolites in response to low-dose radiation exposure, which may contribute to the high mortality and abnormality rates of the butterfly in Fukushima. However, this field effect hypothesis has not been experimentally tested. Here, using an artificial diet for larvae, we examined the ingestional toxicity of three radiation-dependent plant metabolites annotated in a previous metabolomic study: lauric acid (a saturated fatty acid), alfuzosin (an adrenergic receptor antagonist), and ikarugamycin (an antibiotic likely from endophytic bacteria). Ingestion of lauric acid or alfuzosin caused a significant decrease in the pupation, eclosion (survival), and normality rates, indicating toxicity of these compounds. Lauric acid made the egg-larval days significantly longer, indicating larval growth retardation. In contrast, ikarugamycin caused a significant increase in the pupation and eclosion rates, probably due to the protection of the diet from fungi and bacteria. These results suggest that at least some of the radiation-dependent plant metabolites, such as lauric acid, contribute to the deleterious effects of radioactive pollution on the butterfly in Fukushima, providing experimental evidence for the field effect hypothesis. 続きを見る