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| 1.
学位論文（リポジトリ） |
学位
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Erdenebat, Baigali
概要:
Mongolian residential sector including houses and Gers, which are traditional dwellings, becomes not only the biggest energy consumer but also produces the highest share of emissions because of the significant increase of utilizing
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traditional stoves with solid fuels such as charcoal and wood in wintertime. The aim of the thesis is to seek possibilities of a grid-connected solar photovoltaic (PV) system for Mongolian houses/Gers so as to improve the access to electricity and reduce greenhouse gases simultaneously. Solar PV system is considered as ease of installation, less maintenance and the absence of rotation. Moreover, utilizing the proposed system provides the residents much more opportunities such as self-usage and trading the surplus energy to the grid. Due to the mismatch between PV array production and demand, the necessity for battery storage systems increases. Therefore, the battery storage system is included to increase self?consumption. However, depending on tariff structure, consumption, and production, the availability of the systems might be adapted. This dissertation seeks to investigate the possibilities of deploying the grid-integrated residential PY-battery system for Mongolian houses and develop a viable configuration. To investigate the possibilities of the PY-battery system for Mongolian conditions, to begin with, we investigated the current electricity tariff market, household load consumption, and PV generation potential. A simulation model including the PV array, battery storage system, and load for the private house/Ger is developed with historical data. A simple operation strategy based on FIT tariff mechanism using PSIM software is studied. Thereafter, the impacts of numerous households with the PY-battery system on the low-voltage network were investigated. This can be implemented effectively in Mongolian households. It confrrms that tons of harmful emissions can be reduced.
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| 2.
学位論文（リポジトリ） |
学位
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Sarwari, Fakhrullah
概要:
The ethnic makeup of Kabul, the capital of Afghanistan, is diverse, with Pashtun, Tajik, Hazara, and Uzbek ethnic groups
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making up the majority. These distinct culturally rooted groupings are further split based on where they are from geographically within the nation. Following the civil war (1992?1996), which fueled ethnic polarization and spawned strategic clusters within the city, these differences have grown even more prominent. The current study examines ethnic segmentation in Kabul City, particularly emphasizing how historical and modern urban planning initiatives have addressed these disparities. We began by thoroughly assessing the literature on ethnic segregation in urban areas and the existence of ethnic and sub-ethnic groupings in Afghanistan. A化er that, we looked closely at Kabul's formal planning history and considered how the government dealt with ethnic segmentation and urban development. According to our research, smaller sub-ethnic communities are created due to people migrating from rural areas and the return of immigrants. These groups of people are connected by a shared identity known as "Qawm," in which community mosques as communal buildings play a crucial role. Additionally, we discovered that ethnicity significantly influenced Kabul residents'preferences for where to live. We reviewed the five master plans created for Kabul City. Early master plans had little involvement from the community and were essentially technocratic and authoritarian. However, in the fourth master plan (2011), there was a turn toward participatory planning. The most recent urban design framework shows an uneven distribution of economic, administrative, and facility hubs across ethnic groups and looks to have declined in terms of participatory planning. In order to sustain communal cohesion, this study recommends that policymakers consider ethnic and sub-ethnic components in urban planning. The study highlights the need for more thoroughylans to address ethnic division to prevent the city from becoming further polarized.
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| 3.
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大城, 史帆 ; Oshiro, Shiho
概要:
近年メタンハイドレートなどの海底天然資源の海洋開発の進展により、深海探査が不可欠になっている。深海探査の他にも海洋養殖モニタリングやマリンレジャー等での水中ドローンも利用されており、世界中で自立型無人潜水機（AUV: Autonomous
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UnderwaterVehicle）の研究・開発が盛んになってきている。AUV の最大の利点はテザーケーブルを使用せずに完全に自立型で行動する無人潜水艦である。これらの研究・開発で必要不可欠となる水中音響通信は問題が多くあるが、その中でも以下の3 つの問題に焦点を当てた。(1) 問題1 : 有線長による探索エリアの制限現在の水中ドローンはほとんどの機種が有線接続で使用されており、探索エリアがワイヤーの長さによって制限されてしまう。有線接続での問題は探索範囲が制限されること以外にも岩場での断線の可能性などもあるため、無線化されたAUV が要求されている。(2) 問題2 : 定期的にAUV を母船へ回収する必要性問題1 でも提示した通り、現在使用されているAUV のほとんどが有線接続のため、テザーケーブルなしで使用するAUV を動作させるにはAUV 本体を定期的に回収し、中に入っているデータを回収する必要がある。(3) 問題3 : 海面や海底の反射波で発生するマルチパス水中で通信を行う際に発する送受信波は、垂直通信の場合、干渉はあまり発生せずに受信できるのだが、水平通信の場合は海面や海底に反射し、マルチパスが発生する。この問題が最も解決が困難とされており、マルチパス対策は必要不可欠となる。本研究はこれら3 つの問題に対して各自解決策を提案し、シミュレーション及び実験を行った。本論文は全6 章で構成されており、第1 章では研究背景と目的を述べる。第2 章では、本研究に使用する技術の基礎概要を述べている。第3 章では、問題1 と問題3 を解決するべくサイクリックプレフィックス（CP : CyclicPrefix）なしSTBC-MIMO OFDM による水平水中通信を提案した。従来、直交周波数分割多重（OFDM : Orthogonal Frequency Division Multiplexing）を使用する際はシンボル間干渉（ISI : Inter Symbol Interference）やキャリア間干渉（ICI : Inter CarrierInterference）を防ぐため、CP をOFDM シンボルの下部から上部に付加して使用する。しかし、CP を付加することでOFDM のデータ容量が減少してしまう。そこで、CP を付加することなく干渉を対策し、OFDM 通信を行う事が可能かどうかを検討した。ISI はLeft Null Space の直交基底を使用して削除できる。ICI は最小平均二乗誤差（MinimumMean Square Error）の重みを使用することで削除する事ができる。実際にMATLAB にて２送信３受信及び２送信４受信のシミュレーションを行い、マルチパスによる遅延を改善する事ができた。第4 章では、先行研究を基にCP なしSTBC-MIMO OFDM による水平水中通信の研究をさらに改良し、斜投影（OB : Oblique Projection）方式を採用した性能向上を提案した。この方式は、最小二乗法（LS 法 : Least Squares Method）及びハウスホルダー変換によるQR 分解ベースのOB 演算子を使用して構造化ノイズを完全に削除することができる。シiiiミュレーションでは2 送信3 受信及び2 送信4 受信で行い、2 マルチパスと多マルチパスの環境で比較を行った。両環境でもマルチパスによる遅延を抑圧する事ができた。実際に静岡県沼津市の内浦湾で行われた海洋実験では、従来通りのCP ありOFDM システム、何も対策していないCP なしOFDM システム、そして提案したCP なしSTBC OFDM システムのこれら3 つの環境で比較実験を行った。従来方式は何も問題なく通信する事が可能であり、何も対策していないCP なしOFDM システムは干渉の影響を最も受け通信が不可能だった。提案したCP なしSTBC OFDM システムでは遅延を抑圧する事ができており、従来方式同様安定した通信を可能とした。第5 章では、問題1 及び問題2 に焦点を当て、32kHz 帯域幅の水中小領域音響ネットワーク（USAAN : Underwater Small Area Acoustic Network）を使用したプロトタイプの無線水中ロボット制御システムを開発した。このテーマは沖縄高等工業専門学校、その他複数の民間企業と共同研究しており、水中ドローンチームとシステム開発チームに分かれて行った。琉球大学が担当したのはシステム開発チームである。時分割複信（TDD :Time Division Duplex）及びドップラー補正を使用したシステム構成となっており、1 つの基地局と複数のユーザー機器（UE : User Equipment）で無線サービスエリアを作成し、基地局は1.0 秒毎のダウンリンク（DL : Down Link）を送信する。そして、空きスロット中にUE の１つがDL 信号と同期し、アップリンク（UL : Up Link）信号を送信する方法である。今回はTDD-USAAN の有効性を確認すべく、CP は付加したまま行った。シミュレーション結果はドップラー補正が働いており、コンスタレーションの乱れは改善した。静岡県沼津市内浦湾のバージで行われた海洋実験では、16QAM のコンスタレーションは正常に確認された。その後、プロトタイプ無線水中ロボットに組み込み、水中ロボットを実際に制御することに成功し、水中ドローンで撮影した240x213 ピクセルの水中写真をリアルタイムでアップロードする事に成功した。第6 章では、問題1 から問題3 の全てに焦点を当て、2 つの先行研究を基にチャネル伝達関数（CTF : Channel Transfer Function）と初期同期を備えたUWA OFDM 通信システムを提案した。データを受信した際、初期伸び縮み係数β1 を検出するため、OFDM 信号の先頭へ2 つの長いチャープ信号を挿入して周波数差を検出する。その後その値を初期値に適用する事でドップラー補正を行う。CTF ではコンティニュアス・パイロットを使用して検出した値と本来の値のずれを計算し、修正したCTF を使用して等化した結果を出力する。シミュレーションでは提案する方式の方が安定して通信できており、コンスタレーションも歪みを改善する事ができた。無反響プールでの実験はCTF 補正ありとなしを比較し、CTF 補正ありの方がコンスタレーションもクリアに受信できた。最後に第7 章では本研究の成果についてまとめ、冒頭で掲げた3 つの問題点に対応した提案の有効性を明らかにする。そして、今後の展望を述べる。
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| 4.
学位論文（リポジトリ） |
学位
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Viqqi, Kurnianda
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| 5.
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Nobu, Sutra
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| 6.
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Suan, Tan Ee
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| 7.
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Nuryadi, Handung
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| 8.
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Junhwan, Byun
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| 9.
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Manullang, Cristiana
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| 10.
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Dawodi, Mursal
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| 11.
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Ahmadi, Mikaeel
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| 12.
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古栫, 雅裕
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| 13.
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Nasiri, Ahmadullah
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| 14.
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Omine, Takuya ; 大嶺, 卓也
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| 15.
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Mandagi, Ixchel Feibie
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夏目, 矩行 ; Natsume, Noriyuki
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| 17.
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尾崎, 香織 ; Ozaki, Kaori
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| 18.
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Udagawa, Shingo ; 宇田川, 伸吾
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| 19.
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Kise, Hiroki ; 喜瀬, 浩輝
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| 20.
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Kushida, Yuka ; 櫛田, 優花
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| 21.
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21. Elucidation of lunar-synchronized spawning mechanism in tropical grouper fish, Epinephelus merra
Fukunaga, Kodai ; 福永, 耕大
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22. The symbiotic system created by interactions among host sea anemones, anemonefish，and other fish
Hayashi, Kina ; 林, 希奈
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| 23.
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Nakamura, Rie ; 仲村, 理恵
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| 24.
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Maruyama, Nobuyuki ; 丸山, 修幸
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| 25.
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Hirai, Jun ; 平井, 潤
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| 26.
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Ishikawa, Kazuki ; 石川, 和樹
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| 27.
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與座, 明泰
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| 28.
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Mohammad Zahid, NOORI
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| 29.
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Tonmitr, Norrawit
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| 30.
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Rahman, S.M. Moshiar
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Phauk, Sokkhey
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| 32.
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加藤, 司 ; Kato, Tsukasa
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| 33.
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平野, 修也
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| 34.
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Kataoka, Keiichi ; 片岡, 恵一
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| 35.
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Agena, Shinya ; 安慶名, 信也
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| 36.
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Nakayama, Yoshiro ; 中山, 良研
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Gender differences in risks for macrovascular complications in type 2 diabetes mellitus (T2DM) have been well established. However, the impact of gender differences on diabetic retinopathy (DR) has not been fully elucidated. We
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therefore retrospectively explored gender-specific determinants for DR in patients with T2DM in a small sized Japanese cohort in Okinawa. There were 214 patients who were diagnosed as no DR (n = 142) and non-proliferative DR (n = 72) in 2009. During the follow-up of median 7 years, 41/142 of incidence, 26/72 of progression, and 67/214 of incidence and progression were observed, respectively. DR was assessed using the modified international clinical DR severity scales. The risks for incidence, progression as well as incidence and progression of DR were comparable between men and women, respectively. Cox proportional hazard models in multivariate analyses demonstrated that the only common determinant in both men and women for DR was the duration of T2DM. Regarding gender-specific determinants, lower level of serum albumin in men as well as higher HbA1c, lower level of estimated glomerular filtration rate, and lower level of serum uric acid in women were extracted, respectively. Although precise mechanisms for such gender-specific determinants of DR still remain unsolved, the present study would highlight a couple of factors associated with gender-specific determinants for DR in a limited numbers of Japanese cohort. Prospective observational studies on gender-specific determinants of DR in a large scale cohort are warranted to further clarify underlying mechanisms.
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| 37.
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Salatkiewicz, Michal Mateusz
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| 38.
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Yoneda, Susumu ; 米田, 晋
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| 39.
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Millman, Jasmine
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| 40.
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Okitsu, Shiho ; 澳津, 志帆
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| 41.
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Li, Yilin ; 李, 益玲
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| 42.
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Adrianus, Bannepading
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| 43.
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Adewuyi, Oludamilare Bode
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| 44.
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Koswatta, Anupa
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| 45.
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Mizuyama, Masaru ; 水山, 克
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| 46.
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相澤, 正隆
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| 47.
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Biondi, Piera
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| 48.
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Angka, Mahardini
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| 49.
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太田, 格
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| 50.
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Selma, Bouchekioua
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| 51.
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Okuyama, Momoko ; 奥山, 桃子
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| 52.
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Karimata, Yosuke ; 狩俣, 洋介
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| 53.
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Taira, Yusuke ; 平良, 祐介
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| 54.
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Kosaka, Yoshinori ; 小坂, 祥範
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| 55.
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Uehara, Karina ; 上原, 佳里奈
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Kaposi’s sarcoma-associated herpesvirus (KSHV) causes both AIDS-related Kaposi’s sarcoma (KS) and classic KS, but their
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clinical presentations are different, and respective mechanisms remain to be elucidated. The KSHV K1 gene is reportedly involved in tumorigenesis through the immunoreceptor tyrosine-based activation motif (ITAM). Since we found the sequence variations in the K1 gene of KSHV isolated from AIDS-related KS and classic KS, we hypothesized that the transformation activity of the K1 gene contributes to the different clinical presentations. To evaluate our hypothesis, we compared the transformation activities of the K1 gene between AIDS-related KS and classic KS. We also analyzed ITAM activities and the downstream AKT and NF-κB. We found that the transformation activity of AIDS-related K1 was greater than that of classic K1, and that AIDS-related K1 induced higher ITAM activity than classic K1, causing more potent Akt and NF-κB activities. K1 downregulation by siRNA in AIDS-related K1 expressing cells induced a loss of transformation properties and decreased both Akt and NF-κB activities, suggesting a correlation between the transformation activity of K1 and ITAM signaling. Our study indicates that the increased transformation activity of AIDS-related K1 is associated with its clinical aggressiveness, whereas the weak transformation activity of classic type K1 is associated with a mild clinical presentation and spontaneous regression. The mechanism of spontaneous regression of classic KS may provide new therapeutic strategy to cancer.
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| 56.
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Arakaki, Kaoru ; 新垣, かおる
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| 57.
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和仁, 雅明
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| 58.
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清田, 亮二
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| 59.
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MOHAMMAD, ASADUZZAMAN
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又吉, 秀仁
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| 61.
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渡久地, 優
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62. A Study on Algorithms for Multi‐objective Optimization Focusing on Tour Guide Assignment Problem
Lina, Setiyani
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| 63.
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目差, 尚太
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| 64.
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Junditttawong, Tanapat
概要:
学位論文
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| 65.
学位論文（リポジトリ） |
学位
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Ji, Longfei
概要:
学位論文
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| 66.
学位論文（リポジトリ） |
学位
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Hirade, Hitomi ; 平出, 裕美
概要:
学位論文
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| 67.
学位論文（リポジトリ） |
学位
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Wee, Hin Boo
概要:
学位論文
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| 68.
学位論文（リポジトリ） |
学位
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Kitanobo, Seiya ; 北之坊, 誠也
概要:
学位論文
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| 69.
学位論文（リポジトリ） |
学位
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阪内, 香
概要:
学位論文
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| 70.
学位論文（リポジトリ） |
学位
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Lau, Yee Wah
概要:
学位論文
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| 71.
学位論文（リポジトリ） |
学位
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Masucci, Giovanni Diego
概要:
学位論文
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| 72.
学位論文（リポジトリ） |
学位
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大河原, 陽子
概要:
学位論文
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| 73.
学位論文（リポジトリ） |
学位
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Singh, Tanya
概要:
学位論文
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| 74.
学位論文（リポジトリ） |
学位
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Hamamoto, Kouta ; 浜元, 宏太
概要:
学位論文
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| 75.
学位論文（リポジトリ） |
学位
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Kuniyoshi, Shimpei ; 國吉, 真平
概要:
学位論文
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| 76.
学位論文（リポジトリ） |
学位
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Yogi, Satotko ; 與儀, 聡子
概要:
学位論文
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| 77.
学位論文（リポジトリ） |
学位
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Toguchi, Masafumi ; 渡口, 真史
概要:
学位論文
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| 78.
学位論文（リポジトリ） |
学位
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Nakayama, Izumi ; 中山, 泉
概要:
学位論文
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| 79.
学位論文（リポジトリ） |
学位
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Guerrero, Carmina Louise Hugo
概要:
AdultT-cell leukemia/lymphoma (ATL) is ahuman T-cell leukemia virus type 1 (HTLV-1)–associated T-cell malignancy with ge
…
nerally poor prognosis. Although only ;5% of HTLV-1 carriers progress to ATL, early diagnosis is challenging because of the lack of ATL biomarkers. In this study, we analyzed blood plasma profiles of asymptomatic HTLV-1 carriers (ACs); untreated ATL patients, including acute, lymphoma, smoldering, and chronic types; and ATL patients in remission. Through SOMAscan, expression levels of 1305 plasma proteins were analyzed in 85 samples (AC, n 5 40; ATL, n 5 40; remission, n 5 5). Using gene set enrichment analysis and gene ontology, overrepresented pathways in ATL vs AC included angiogenesis, inflammation by cytokines and chemokines, interleukin-6 (IL-6)/JAK/STAT3, and notch signaling. In selecting candidate biomarkers, we focused on soluble tumor necrosis factor receptor 2 (sTNFR2) because of its active role in enriched pathways, extreme significance (Welch’s t test P , .00001), high discrimination capacity (area under the curve .0.90), and novelty in ATL research. Quantification of sTNFR2 in 102 plasma samples (AC, n530; ATL, n568; remission, n54) using enzyme-linked immunosorbent assay showed remarkable elevations in acute ATL, at least 10 times those of AC samples, and return of sTNFR2 to AC state levels after achieving remission. Flow cytometry and immunostaining validated the expression of TNFR2 in ATL cells. No correlation between sIL-2 and sTNFR2 levels in acute ATL was found, suggesting the possibility of sTNFR2 as an independent biomarker. Our findings represent the first extensive blood-based proteomic analysis of ATL, suggesting the potential clinical utility of sTNFR2 in diagnosing acute ATL.
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| 80.
学位論文（リポジトリ） |
学位
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Takayama, Tomomi ; 髙山, 智美
概要:
学位論文
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| 81.
学位論文（リポジトリ） |
学位
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Utsumi, Daisuke ; 内海, 大介
概要:
Background: Trichorrhexis invaginata, the main diagnostic feature of Netherton syndrome, is often difficult to detect, e
…
specially in adult patients.
Objective: We sought to describe a characteristic feature of hairs in Netherton syndrome using a polarized light microscope and the underlying histopathologic changes. Methods: Hairs obtained from 8 patients with Netherton syndrome were observed under polarized light, and we evaluated the correlation between number of band-like patterns and disease severity. Results: Under polarized microscopy, the hair shafts of 8 patients showed a characteristic band-like pattern under polarized light that was not observed in healthy control individuals or patients with atopic dermatitis. This discontinuity of polarized light shows a band-like pattern in which the bands mostly ranged from 0.1 to 1.0 mm in width. The observed ratio of this finding was significantly higher than that of trichorrhexis invaginata observed under light microscopy, and patients with severe dermatitis tended to have a higher ratio than those with less severe dermatitis. Limitations: Comparative examination among other congenital ichthyoses was not performed. Conclusions: A band-like pattern in hairs with polarized light microscopy can be seen in Netherton syndrome and may have potential utility as a diagnostic marker. 学位論文 続きを見る |
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| 82.
学位論文（リポジトリ） |
学位
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Rosantia, Sarassari
概要:
Enterobacteriaceae isolates producing CTX-M-type extended-spectrum b-lactamase (ESBL) has been found in hospitalized pat
…
ients and healthy individuals in communities of the Southeast Asian countries. Medical students might have more risk of ESBL-producing Enterobacteriaceae contagion, because medical students who belong to communities have direct and indirect contacts with workers and patients in healthcare facilities. The aim of this study was to collect information for evaluation of the potential risk of ESBL-producing Enterobacteriaceae contagion in Indonesian undergraduate medical students by characterizing genotypic properties of Escherichia coli isolates-producing CTX-M-type ESBL. A total 141 fecal samples collected from 207 medical students of a university in Surabaya, Indonesia were subjected to PCR, XbaI and S1 nuclease-pulsed-field gel electrophoresis (PFGE), Southern blotting, and sequencing analysis. Eighty-two ESBL-producing Enterobacteriaceae, including 75 E. coli and 7 Klebsiella pneumoniae were isolated from 79 (56.0%) students. Among 75 ESBL-producing E. coli, blaCTX-M-15 was the most prevalent type (44.0%). Although XbaI-PFGE results showed genetic background of the E. coli isolates producing CTX-M-type ESBL were diverse, five clonal spread cases of certain E. coli producing CTX-Mtype ESBL isolates were observed among the medical students. Our results suggested that ESBLproducing Enterobacteriaceae might be circulating among the medical students through contaminated environment such as in a university or communities they belonged.
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| 83.
学位論文（リポジトリ） |
学位
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Abe, Norie ; 阿部, 典恵
概要:
As visual quantification of the density of tumor-infiltrating lymphocytes (TILs) lacks in precision, digital image analy
…
sis (DIA) approach has been applied in order to improve. In several studies, TIL density has been examined on hematoxylin and eosin (HE)-stained sections using DIA. The aim of the present study was to quantify TIL density on HE sections of core needle biopsies using DIA and investigate its association with clinicopathological parameters and pathological response to neoadjuvant chemotherapy in human epidermal growth factor receptor 2 (HER2)-positive breast cancer. The study cohort comprised of patients with HER2-positive breast cancer, all treated with neoadjuvant anti-HER2 therapy. DIA software applying machine learning-based classification of epithelial and stromal elements was used to count TILs. TIL density was determined as the number of TILs per square millimeter of stromal tissue. Median TIL density was 1287/mm^2 (range, 123–8101/mm^2). A high TIL density was associated with higher histological grade (P = 0.02), estrogen receptor negativity (P = 0.036), and pathological complete response (pCR) (P < 0.0001). In analyses using receiver operating characteristic curves, a threshold TIL density of 2420/mm^2 best discriminated pCR from non-pCR. In multivariate analysis, high TIL density (> 2420/mm^2) was significantly associated with pCR (P < 0.0001). Our results indicate that DIA can assess TIL density quantitatively, machine learning-based classification algorithm allowing determination of TIL density as the number of TILs per unit area, and TIL density established by this method appears to be an independent predictor of pCR in HER2-positive breast cancer.
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| 84.
学位論文（リポジトリ） |
学位
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Nagata, Masashi ; 永田, 仁
概要:
Background: Our previous report described how postoperative progression of sarcopenia predicted longterm prognosis after
…
complete resection of non-small cell lung cancer (NSCLC) in heavy smokers. However, there are currently no effective means to treat progressive sarcopenia. In this study, we aimed to confirm our previous findings in a larger population and to identify factors associated with postoperative progression of sarcopenia to propose possible preventative measures.Methods: This retrospective study analyzed the data of 1,095 patients who underwent curative lobar resection for NSCLC at Kanagawa Cancer Center. We divided patients into four groups according to sex and Brinkman index (BI) above or below 600. Six-month postoperative changes in the skeletal muscle index (SMI) were calculated and associations between clinicopathological factors including changes in SMI and mortality from postoperative 6 months were examined. Only in groups in which postoperative depletion of SMI was shown to be associated with the prognosis, we identified clinicopathological factors associated with depletive SMI.Results: The overall survival rates of 1,095 patients were 89.8% and 82.5% at 3 and 5 years, respectively. The median 6-month change in SMI was –3.4% (range, −22.3% to +17.9%). Multivariate analysis revealed that poor prognosis was independently predicted by a large reduction in the SMI (cut-off value: −10%) in males with a BI ≥600. In 391 heavy-smoking males, factors associated with a postoperative change in SMI ≤−10% were history of other cancers (including gastric cancer) low forced expiratory volume in one second (FEV 1.0, cut-off value: 1,870 mL), and prolonged operation time (cut-off value: 200 minutes).Conclusions: Perioperative measures to prevent postoperative sarcopenia are appropriate for heavy smokers. We obtained some clues regarding countermeasures, one of which may be avoiding long-time operation. Further studies including clinical trials to assess perioperative anti-sarcopenia treatments, are needed.
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| 85.
学位論文（リポジトリ） |
学位
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Xu, Yanyan ; 徐, 妍妍
概要:
Purpose: To evaluate the advantages of ultra-high-resolution computed tomography (U-HRCT) scans for the quantitative mea
…
surement of emphysematous lesions over conventional HRCTscans. Materials and methods: This study included 32 smokers under routine clinical care who underwent chest CT performed by a U-HRCT scanner. Chronic obstructive pulmonary disease (COPD) was diagnosed in 13 of the 32 participants. Scan data were reconstructed by 2 different protocols: i) U-HRCT mode with a 1024×1024 matrix and 0.25-mm slice thickness and ii) conventional HRCT mode with a 512×512 matrix and 0.5-mm slice thickness. On both types of scans, lesions of emphysema were quantitatively assessed as percentage of low attenuation volume (LAV%, <−950 Hounsfield units). LAV% values determined for scan data from the U-HRCT and conventional HRCT modes were compared by the Wilcoxon matched-pairs signed rank test. The association between LAV% and forced expiratory volume in 1 s per forced vital capacity (FEV_1/FVC) was assessed by the Spearman rank correlation test. Results: Mean values for LAV% determined for the U-HRCT and conventional HRCT modes were 8.9 ± 8.8% and 7.3 ± 8.4%, respectively (P<0.0001). The correlation coefficients for LAV% and FEV_1/FVC on the U-HRCT and conventional HRCT modes were 0.50 and 0.49, respectively (both P<0.01). Conclusion: Compared with conventional HRCT scans, U-HRCT scans reveal emphysematous lesions in greater detail, and provide slightly increased correlation with airflow limitation.
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| 86.
学位論文（リポジトリ） |
学位
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平良, 勝保 ; Taira, Katsuyasu
概要:
学位論文
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| 87.
学位論文（リポジトリ） |
学位
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Pedro Munoz, Ramirez ; ペドロ ムニョス, ラミレス
概要:
学位論文
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| 88.
学位論文（リポジトリ） |
学位
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Vilay, Phoutnalong
概要:
学位論文
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| 89.
学位論文（リポジトリ） |
学位
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Crystal, Amiel M.Estrada
概要:
学位論文
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| 90.
学位論文（リポジトリ） |
学位
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Park, Kyung Bae ; パク, キョンベ
概要:
学位論文
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| 91.
学位論文（リポジトリ） |
学位
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Arezoo, Mottaghi ; アレズー, モッタギ
概要:
学位論文
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| 92.
学位論文（リポジトリ） |
学位
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長坂, 康史 ; Nagasaka, Yasushi
概要:
学位論文
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| 93.
学位論文（リポジトリ） |
学位
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Hokama, Noboru ; 外間, 登
概要:
Xanthine oxidase (XO) is a rate limiting enzyme for production of uric acid. The activity of XO in plasma is reported to
…
elevate in patients with familial hypercholesterolaemia and cardiovascular diseases. Such an increase in plasma XO activity was also demonstrated in patients with a variety of cancers. However, there have been few reports evaluating the plasma XO activity in patients with hematological malignancies during course of allogeneic hematopoietic stem cell transplantation (allo-HSCT) and chemotherapies. We explored the relationship between plasma XO activity and clinical symptoms/biochemical parameters in 10 patients with hematological malignancies. The XO activity was measured by a highsensitivity fluorescence technique. Plasma XO activity in hematological malignancies before chemotherapy was not elevated compared to healthy subjects. In patients receiving allo-HSCT, no apparent increase in plasma XO activity was observed at the appearance of graft-versus-host disease (GVHD). Noticeably, however, the value of plasma XO activity was closely associated with that of serum level of liver transaminases in the course of allo-HSCT and chemotherapies. To our knowledge, the present study is the first to investigate consecutively the value in plasma XO activity in patients with hematological malignancies. Despite small numbers analyzed, value of plasma XO activity was tightly associated with that of serum level of liver transaminases in the course of allo-HSCT and chemotherapies, suggesting that the value may reflect liver damage related with a variety of therapeutic interventions.
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| 94.
学位論文（リポジトリ） |
学位
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Shinzato, Hotaka ; 新里, 輔鷹
概要:
Background: Conventional categorical criteria have limitations in assessing the prevalence and severity of depressive mi
…
xed state (DMX). Thus, we have developed a new scale for screening and quantification of DMX and examined the symptomatological structure and severity of DMX in individuals with major depressive episode (MDE). Methods: Subjects were 154 patients with MDE (57 males and 97 females; age 13–83 years). Our original Japanese version of the self-administered 12-item questionnaire to assess DMX (DMX-12), together with the Quick Inventory of Depressive Symptomatology Self- Report Japanese version (QIDS-SR-J) and global assessment of functioning, were administered to each participant. The symptomatological structure of the DMX-12 was examined by exploratory factor analysis. Multiple regression analyses were used to analyze factors contributing to the DMX-12 scale. The relationships of this scale with categorical diagnoses (mixed depression by Benazzi and mixed features by DSM-5) were also investigated. Results: A three-factor model of the DMX-12 was extracted from exploratory factor analysis, namely, “spontaneous instability”, “vulnerable responsiveness”, and “disruptive emotion/behavior”. Multiple regression analyses revealed that age was negatively correlated with total DMX-12 score, while bipolarity and the QIDS-SR-J score were positively correlated. A higher score on the disruptive emotion/behavior subscale was observed in patients with mixed depression and mixed features. Conclusion: The DMX-12 seems to be useful for screening DMX in conjunction with conventional categorical diagnoses. Severely depressed younger subjects with potential bipolarity are more likely to develop DMX. The disruptive emotion/behavior subscale of the DMX-12 may be the most helpful in distinguishing patients with DMX from non-mixed patients.
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| 95.
学位論文（リポジトリ） |
学位
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Yamaguchi, Satoshi ; 山口, 怜
概要:
Background Left ventricular (LV) wall thickening relative to the LV radius, known as a concentric LV structure, is a mec
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hanism that compensates for pressure overload and is related to the risk of cardiovascular events and heart failure. The prognostic value of a concentric LV structure, however, has not been examined in acute decompensated heart failure (ADHF). Methods This single-center, observational, retrospective, cohort study analyzed 385 consecutive patients hospitalized due to ADHF. On hospital admission, relative wall thickness (RWT) and the ratio of LV mass to LV end-diastolic volume (LVM/LVEDV) were measured by transthoracic echocardiography as markers of a concentric LV structure. The association of either RWT or LVM/LVEDV with all-cause death as the primary outcome was analyzed. Results During the follow-up period (median, 235 days), 95 (25%) patients died. The high-RWT group had a poorer prognosis than the low-RWT group (log-rank test, P = 0.009). High RWT was a significant risk (HR: 1.95, 95% CI: 1.28–2.97, P = 0.002) in the Cox proportional hazard model analysis adjusted by the Get With The Guideline score, which is an established risk score. In contrast, there was no significant difference in survival between the low and high-LVM/LVEDV groups (P = 0.42). In the non-severe valvular disease subgroup, patients with high RWT consistently showed worse survival than the low- RWT group (P = 0.028 by log-rank test, HR: 1.96, 95% CI: 1.24–3.11, P = 0.004). There was no significant difference in survival between the low and high-LVM/LVEDV groups (P = 0.42). Conclusions A concentric LV structure represented by a high RWT was associated with a poor prognosis in ADHF. The lack of association between LVM/LVEDV and mortality may result from methodological issues.
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| 96.
学位論文（リポジトリ） |
学位
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Morichika, Kazuho ; 森近, 一穂
概要:
Adult T‐cell leukemia/lymphoma (ATLL) is a mature T‐cell neoplasm, and is divided into 2 indolent (smoldering and chroni
…
c) and 2 aggressive (acute and lymphoma) clinical subtypes. Based on previous integrated molecular analyses suggesting the importance of the JAK‐STAT pathway in ATLL, we attempted to clarify the clinicopathological significance of this pathway. Clinical and morphological findings were reviewed in 116 cases with ATLL. The nuclear localizations of phosphorylated STAT3 (pSTAT3), pSTAT5, and pSTAT6 were analyzed by immunohistochemistry. Targeted sequencing was undertaken on the portion of STAT3 encoding the Src homology 2 domain. Expression of pSTAT3 was observed in 43% (50/116) of ATLL cases, whereas pSTAT5 and pSTAT6 were largely undetected. Cases with the lymphoma type showed significantly less frequent pSTAT3 expression (8/45, 18%) than those with the other subtypes (41/66, 62%; P < .001). STAT3 mutations were detected in 36% (10/28) and 19% (12/64) of cases with the smoldering and aggressive types of ATLL, respectively. The correlation between STAT3 mutation and pSTAT3 expression was not significant (P = .07). Both univariate and multivariate analysis revealed that pSTAT3 expression was significantly associated with better overall survival and progression‐free survival in the smoldering type of ATLL, whereas STAT3 mutation was not related to a line of clinical outcome. Collectively, our data show that only the lymphoma type showed a low prevalence of tumor cells positive for pSTAT3 expression, and raises the possibility that pSTAT3 expression is a novel biomarker to predict better prognosis in the smoldering type of ATLL.
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| 97.
学位論文（リポジトリ） |
学位
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Toyama, Yuko
概要:
学位論文
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| 98.
学位論文（リポジトリ） |
学位
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Kaneshiro, Yukako ; 兼城, 縁子
概要:
学位論文
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| 99.
学位論文（リポジトリ） |
学位
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Koyama, Satoshi ; 小山, 智士
概要:
学位論文
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| 100.
学位論文（リポジトリ） |
学位
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Oshiro, Hiromichi ; 大城, 裕理
概要:
学位論文
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