※一部利用できない機能があります
1.
論文(リポジトリ) |
Uehara, Tadashi ; Yohena, Tomofumi ; Kanematsu, Takanori ; Teruya, Takao ; Ikeda, Jiro ; Okamoto, Junichi ; Asoh, Hiroshi ; Ichinose, Yukito
概要:
Purpose: The optimal treatment modality for delayed emesis occurring later than 24 hours after the administration of cis
…
platin-based chemotherapy has not yet been established. Patients and Methods: Twenty patients received 5-hydroxytryptamine 3 receptor antagonist intravenously for the treatment of acute emesis just before cisplatm infusion in the first cycle of treatment, and the thereafter they received oral administration of betamethason ($\2mgtimes3/day$) plus oral lorazepam ($\0.5mgtimes3/day$) for 5 days in trial I. In trial II, 14 patients who received the other anti-emetic regimen (methylprednisolone plus metoclopramide) for delayed emesis in the first cycle of chemotherapy were treated by this regimen for the second cycle of treatment. A complete response (CR) was defined as no emetic episodes and a partial response (PR) as no vomiting episodes but some nausea. The effects of anti-emetic treatments were evaluated for 5 days from the next day after cisplatin administration. Results: The mean control rate (percentage of CR+PR) and CR rate for delayed emesis for the 5-day period were 97% and 84%, respectively in trial I. The mean control rate in patients undergoing the other anti-emetic regimen in the first cycle of chemotherapy was 60% compared to 96% in the same patients undergoing this regimen in the second cycle of the same chemotherapy in trial II. Conclusions: Oral betamethason plus lorazepam demonstrated a high control rate for delayed nausea and vomiting induced by cisplatin-based chemotherapy.
論文 続きを見る |
|||||
2.
図書 |
D.G. Grahame-Smith and J.K. Aronson
|
|||||
3.
図書 |
editors, Joel G. Hardman, Lee E. Limbird ; consulting editor, Alfred Goodman Gilman
|
|||||
4.
図書 |
editors-in-chief, Joel G. Hardman, Lee E. Limbird ; editors, Perry B. Molinoff, Raymond W. Ruddon ; consulting editor, Alfred Goodman Gilman
|
|||||
5.
図書 |
editors, Alfred Goodman Gilman ... [et al.]
|
|||||
6.
図書 |
prepared by the American Medical Association Department of Drugs, Division of Drugs and Technology ; in cooperation with the American Society for Clinical Pharmacology and Therapeutics
|
|||||
7.
図書 |
Sachin N. Pradhan, editor ; Roger P. Maickel, Samar N. Dutta, associate editor
|
|||||
8.
図書 |
Goodman, Louis Sanford, 1906- ; Gilman, Alfred Goodman, 1941- ; Rall, Theodore W., 1928- ; Murad, Ferid
|
|||||
9.
図書 |
edited by Graeme S. Avery
|
|||||
10.
図書 |
Goodman, Louis Sanford, 1906- ; Gilman, Alfred, 1908- ; Gilman, Alfred Goodman, 1941-
|