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Nakanishi, Shotaro ; Goya, Masato ; Tamaki, Mitsuyoshi ; Oshiro, Takuma ; Saito, Seiichi
出版情報: BMC Research Notes.  14  2021-06-03.  Springer Nature
URL: http://hdl.handle.net/20.500.12000/49968
概要: Objective:To date, there are no useful markers for predicting the prognosis of metastatic hormone-sensitive prostate can cer (mHSPC). We evaluated the effect of early changes in prostate-specific antigen (PSA) levels after androgen deprivation therapy (ADT) on castration-resistant prostate cancer (CRPC) progression and overall survival (OS) in mHSPC patients.\nResults:In 71 primary mHSPC patients treated with ADT, the median times to CRPC and OS were 15 months and 92 months, respectively. In multivariate analysis, a Gleason score of ≥ 8 (p = 0.004), an extent of disease value (EOD) of ≥ 2 (p = 0.004), and a 3-month PSA level > 1% of the pretreatment level (p = 0.017) were independent predictors of shorter time to CRPC. The area under the receiver operating characteristic curve was feasible at 0.822. A 3-month PSA level > 1% of the pretreatment level was an independent predictor of OS (p = 0.004). Three factors were independent predictors of shorter time to CRPC. A 3-month PSA level > 1% of the pretreatment level correlated with a poor prognosis.
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2.

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Nakanishi, Shotaro ; Nishida, Sho ; Miyazato, Minoru ; Goya, Masato ; Saito, Seiichi
出版情報: Urology Case Reports.  29  2020-03.  Elsevier
URL: http://hdl.handle.net/20.500.12000/49945
概要: We present a 78-year-old male with renal cell carcinoma who developed myasthenia gravis complicated by myositis after ni volumab administration, which was verified by the presence of antibodies against the acetylcholine receptor. The initial symptom was posterior neck pain, and biochemical examination of blood showed elevated levels of hepatic enzymes and creatine phosphokinase. The level of antibody against the acetylcholine receptor increased 4.1-fold. His condition progressed rapidly resulting in respiratory failure 15 days after conservative therapy.
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3.

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Nakanishi, Shotaro ; Nishida, Sho ; Miyazato, Minoru ; Goya, Masato ; Saito, Seiichi
出版情報: Urology Case Reports.  29  2020-03.  Elsevier
URL: http://hdl.handle.net/20.500.12000/47488
概要: We present a 78-year-old male with renal cell carcinoma who developed myasthenia gravis complicated by myositis after ni volumab administration, which was verified by the presence of antibodies against the acetylcholine receptor. The initial symptom was posterior neck pain, and biochemical examination of blood showed elevated levels of hepatic enzymes and creatine phosphokinase. The level of antibody against the acetylcholine receptor increased 4.1-fold. His condition progressed rapidly resulting in respiratory failure 15 days after conservative therapy.
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4.

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大城, 吉則 ; 安次嶺, 聡 ; 木村, 隆 ; 宮城, 亮太 ; 玉城, 由光 ; 仲西, 昌太郎 ; 松村, 英理 ; 大城, 琢磨 ; 宮里, 実 ; 呉屋, 真人 ; 斎藤, 誠一 ; Oshiro, Yoshinori ; Ashimine, Satoshi ; Kimura, Ryu ; Miyagi, Ryota ; Tamaki, Mitsuyoshi ; Nakanishi, Syotarou ; Matsumura, Eiri ; Oshiro, Takuma ; Goya, Masato ; Miyazato, Minoru ; Saito, Seiichi
出版情報: 移植.  51  pp.40-47,  2016-03-10.  一般社団法人 日本移植学会 — The Japan Society for Transplantation
URL: http://hdl.handle.net/20.500.12000/47494
概要: 【Objective】Good long-term kidney graft function and graft survival depend on multiple factors. This study aimed to asses s the impact of donor and recipient clinical factors on 20-year graft survival after kidney transplantation (KT).\n【Material and Methods】From 1987-1994, twenty-five KTs (14 living and 11 deceased donors) were performed at Ryukyu University Hospital, and 24 of these cases were followed for more than 20 years after the KTs and reviewed. Ten patients had 20 years of graft survival, and 14 experienced graft failure for some reason within 20 years after KTs. Retrospective analyses were performed to elucidate the difference in donor and recipient factors among these patients.\n【Results】The death censored graft survival rates at 5, 10, 15, and 20 years were 92.0%, 83.0%, 67.0%, and 67.0% in living-donor KTs and 73.0%, 62.0%, 62.0%, and 31.0% in deceased-donor KTs, respectively. The overall graft survival rates at 5, 10, 15, and 20 years were 85.0%, 77.0%, 62.0%, and 54.0% in living-donor KTs and 63.0%, 55.0%, 45.0%, and 27.0% in deceased-donor KTs, respectively. Comparison of clinical factors between the ≥ 20-year graft survivor group (10 cases) and <20-year graft survivor group (14 cases) revealed no differences in, for example, recipient age, duration of dialysis, donor age, donor type, number of human leukocyte antigen mismatches, and occurrence of acute rejections within 1 year of KTs. However, among 13 cases of living-donor KTs, the overall graft survivals after KTs from donors older than 50 years were worse than those after KTs from donors younger than 50 years. Also, the death-censored graft survivals after KTs from donors older than 60 years were worse than those after KTs from donors younger than 60 years. Moreover, graft survivals after KTs from maternal donors were worse than those after KTs from nonmaternal living donors, and there were no 20-year graft survivors after KTs from maternal donors.\n【Conclusion】Our results suggest that the principal risk factors associated with <20-year graft survival after living-donor KTs are the presence of donors older than 50 or 60 years and a maternal donor.
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5.

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Miyazato, Minoru ; Yamashiro, Satoshi ; Goya, Masato ; Inafuku, Hitoshi ; Ikehara, Akashi ; Oshiro, Yoshinori ; Saito, Seiichi ; Kuniyoshi, Yukio
出版情報: BMC Research Notes.  7  2014-10-01.  BioMed Central
URL: http://hdl.handle.net/20.500.12000/47331
概要: Background: Renal cell carcinoma with tumor thrombus extension into the inferior vena cava occurs in approximately 5% of cases. Despite such situations, an aggressive surgical approach is recommended. However, intraoperative prevention of pulmonary embolism by a fragmended tumor thrombus is necessary. To prevent pulmonary embolism, placement of a temporary suprarenal filter has been attempted, however, the precise placement of a temporary filter between the level of the hepatic vein and right atrium is not always easy because of its migration, tilting, and strut fracture. Here we report a method for early occlusion control of the intrapericardial inferior vena cava to prevent pulmonary embolism during nephrectomy in level II or III renal cell carcinoma tumor thrombus.\nCase presentation: Our first case was a 37-year-old Japanese man with left renal cell carcinoma extending into the inferior vena cava below the main hepatic vein (level II) and our second was a 75-year-old Japanese man with right renal cell carcinoma extending into the retrohepatic inferior vena cava at the main hepatic vein (level III). En block resection of the kidney and the tumor thrombus was performed with the aid of partial extracorporeal circulation; the postoperative course of both patients was uneventful.\nConclusion: Control of intrapericardial inferior vena cava is a feasible method to prevent pulmonary embolism.
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6.

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Miyazato, Minoru ; Yamashiro, Satoshi ; Goya, Masato ; Inafuku, Hitoshi ; Ikehara, Akashi ; Oshiro, Yoshinori ; Saito, Seiichi ; Kuniyoshi, Yukio
出版情報: BMC Research Notes.  7  2014-10-01.  BioMed Central
URL: http://hdl.handle.net/20.500.12000/47506
概要: Background: Renal cell carcinoma with tumor thrombus extension into the inferior vena cava occurs in approximately 5% of cases. Despite such situations, an aggressive surgical approach is recommended. However, intraoperative prevention of pulmonary embolism by a fragmended tumor thrombus is necessary. To prevent pulmonary embolism, placement of a temporary suprarenal filter has been attempted, however, the precise placement of a temporary filter between the level of the hepatic vein and right atrium is not always easy because of its migration, tilting, and strut fracture. Here we report a method for early occlusion control of the intrapericardial inferior vena cava to prevent pulmonary embolism during nephrectomy in level II or III renal cell carcinoma tumor thrombus.\nCase presentation: Our first case was a 37-year-old Japanese man with left renal cell carcinoma extending into the inferior vena cava below the main hepatic vein (level II) and our second was a 75-year-old Japanese man with right renal cell carcinoma extending into the retrohepatic inferior vena cava at the main hepatic vein (level III). En block resection of the kidney and the tumor thrombus was performed with the aid of partial extracorporeal circulation; the postoperative course of both patients was uneventful.\nConclusion: Control of intrapericardial inferior vena cava is a feasible method to prevent pulmonary embolism.
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7.

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宮里, 実 ; 有賀, 拓郎 ; 前本, 均 ; 草田, 武朗 ; 芦刈, 明日香 ; 上間, 南海子 ; 宮城, 亮太 ; 仲西, 昌太郎 ; 呉屋, 真人 ; 村山, 貞之 ; 斎藤, 誠一 ; Miyazato, Minoru ; Ariga, Takuro ; Maemoto, Hitoshi ; Kusada, Takeaki ; Ashikari, Asuka ; Uema, Namiko ; Miyagi, Ryota ; Nakanishi, Shotaro ; Goya, Masato ; Murayama, Sadayuki ; Saito, Seiichi
出版情報: 琉球医学会誌 = Ryukyu Medical Journal.  37  pp.13-17,  琉球医学会 — Ryukyu Medical Association
概要: Background: We retrospectively evaluated the outcome of brachytherapy with permanent iodine-125 seed implantation for pr ostate cancer. Methods: From 2009 to2016, 150 patients(49 in low risk, 81 intermediate, 20 high),mean age 67.1 y, which were performed brachytherapy in our hospital were enrolled in this study. Results: The average prostate volume was 27.4cc, mean International Prostate Symptom Score 9 in these patients. In postplan evaluation, mean prostate V100 93.8%, D90 in brachytherapy alone 173.9Gy, combined with external beam radiation 116.8Gy, rectum V100 in brachytherapy alone 0.27cc, combined with external beam radiation 0.13cc, urethraD90 in brachytherapy alone 89.9Gy, combined with external beam radiation 64.4Gy. The biochemical progression-free survival in 5 years was 97.0% in low risk, while 96.3% in intermediate and no patients in high risk demonstrated PSA relapse during the observation. Migration of seeds was occurred in 3.3%. Adverse event was urinary retention in 2, hematuria in 2, proctitis in 2, rectal bleeding in 2, more than grade 3 was noted in only one patient. Conclusions: The outcome of brachytherapy in our hospital was safe and feasible with low side effects.
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