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1.
論文(リポジトリ) |
Trautmann, Agnes ; Vivarelli, Marina ; Samuel, Susan ; Gipson, Debbie ; Sinha, Aditi ; Schaefer, Franz ; Hui, Ng Kar ; Boyer, Olivia ; Saleem, Moin A ; Feltran, Luciana ; Müller-Deile, Janina ; Becker, Jan Ulrich ; Cano, Francisco ; Xu, Hong ; Lim, Yam Ngo ; Smoyer, William ; Anochie, Ifeoma ; Nakanishi, Koichi ; Hodson, Elisabeth ; Haffner, Dieter ; International Pediatric Nephrology Association
概要:
Idiopathic nephrotic syndrome newly affects 1–3 per 100,000 children per year. Approximately 85% of cases show complete
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remission of proteinuria following glucocorticoid treatment. Patients who do not achieve complete remission within 4–6 weeks of glucocorticoid treatment have steroid-resistant nephrotic syndrome (SRNS). In 10–30% of steroid-resistant patients, mutations in podocyte-associated genes can be detected, whereas an undefined circulating factor of immune origin is assumed in the remaining ones. Diagnosis and management of SRNS is a great challenge due to its heterogeneous etiology, frequent lack of remission by further immunosuppressive treatment, and severe complications including the development of end-stage kidney disease and recurrence after renal transplantation. A team of experts including pediatric nephrologists and renal geneticists from the International Pediatric Nephrology Association (IPNA), a renal pathologist, and an adult nephrologist have now developed comprehensive clinical practice recommendations on the diagnosis and management of SRNS in children. The team performed a systematic literature review on 9 clinically relevant PICO (Patient or Population covered, Intervention, Comparator, Outcome) questions, formulated recommendations and formally graded them at a consensus meeting, with input from patient representatives and a dietician acting as external advisors and a voting panel of pediatric nephrologists. Research recommendations are also given.
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2.
図書 |
[edited by] Karen J. Marcdante, Robert M. Kliegman
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3.
図書 |
[edited by] Robert M. Kliegman ... [et al.] ; editor emeritus Richard E. Behrman
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4.
図書 |
[edited by] Robert M. Kliegman ... [et al.]
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5.
図書 |
Robert M. Kliegman ... [et al.]
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6.
図書 |
[edited by] Richard E. Behrman, Robert M. Kliegman, Hal B. Jenson
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7.
図書 |
[edited by] Richard E. Behrman, Robert M. Kliegman, Hal B. Jenson
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8.
図書 |
edited by Richard E. Behrman, Robert M. Kliegman, Ann M. Arvin ; senior editor, Waldo E. Nelson
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9.
図書 |
飯島, 宗一(1922-)
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10.
図書 |
飯島宗一 [ほか] 責任編集
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