※一部利用できない機能があります
| 1.
論文（リポジトリ） |
論文（リポジトリ）
|
前原, 健大 ; Takehiro, Maehara
概要:
本稿では依存格理論（Marantz 1991）と呼ばれる形態格付与に関する理論を用いて日本語受動文の分析を行なった。依存格理論では構造中のDP間のc統御関係により付与する格を決定するため、分析対象となる文の正確な統語構造を知ることが必要とな
…
ってくる。そこで、2節では先行研究を基に本稿における受動文の構造を仮定した。3節では前節で仮定した受動文の構造を基に依存格理論による分析を行なった。ここでは、前原（2021）における依存格付与規則を基に分析を進めた。その結果、前原にて提案されている格付与規則を用いることで、日本語受動文においても適格な格付与を行うことができることが分かった。また、格付与規則の適用はスペルアウトと同時に、TPを一単位として行われるのが適切でるということも分かった。
本論文は「九州地区国立大学教育系・文系研究論文集」Vol.8, No.2(2022/3）に査読を経て受理された。 続きを見る |
||||||
| 2.
論文（リポジトリ） |
論文（リポジトリ）
|
Matsunami, Masatoshi ; Koganebuchi, Kae ; Imamura, Minako ; Ishida, Hajime ; Kimura, Ryosuke ; Maeda, Shiro
概要:
The Ryukyu Archipelago is located in the southwest of the Japanese islands and is composed of dozens of islands, grouped
…
into the Miyako Islands, Yaeyama Islands, and Okinawa Islands. Based on the results of principal component analysis on genome-wide single-nucleotide polymorphisms, genetic differentiation was observed among the island groups of the Ryukyu Archipelago. However, a detailed population structure analysis of the Ryukyu Archipelago has not yet been completed. We obtained genomic DNA samples from 1,240 individuals living in the Miyako Islands, and we genotyped 665,326 single-nucleotide polymorphisms to infer population history within the Miyako Islands, including Miyakojima, Irabu, and Ikema islands. The haplotype-based analysis showed that populations in the Miyako Islands were divided into three subpopulations located on Miyakojima northeast, Miyakojima southwest, and Irabu/Ikema. The results of haplotype sharing and the D statistics analyses showed that the Irabu/Ikema subpopulation received gene flows different from those of the Miyakojima subpopulations, which may be related with the historically attested immigration during the Gusuku period (900 − 500 BP). A coalescent-based demographic inference suggests that the Irabu/Ikema population firstly split away from the ancestral Ryukyu population about 41 generations ago, followed by a split of the Miyako southwest population from the ancestral Ryukyu population (about 16 generations ago), and the differentiation of the ancestral Ryukyu population into two populations (Miyako northeast and Okinawajima populations) about seven generations ago. Such genetic information is useful for explaining the population history of modern Miyako people and must be taken into account when performing disease association studies.
論文 続きを見る |
||||||
| 3.
論文（リポジトリ） |
論文（リポジトリ）
|
Hara, Ryoki ; Umebayashi, Hiroaki ; Takei, Syuji ; Okamoto, Nami ; Iwata, Naomi ; Yamasaki, Yuichi ; Nakagishi, Yasuo ; Kizawa, Toshitaka ; Kobayashi, Ichiro ; Imagawa, Tomoyuki ; Kinjo, Noriko ; Amano, Norihito ; Takahashi, Yoko ; Mori, Masaaki ; Itoh, Yasuhiko ; Yokota, Shumpei
概要:
Background: To investigate efficacy and safety of intravenous abatacept in Japanese patients with active polyarticular-c
…
ourse juvenile idiopathic arthritis (pJIA). Methods: In this phase III, open-label, multicenter, single-arm study, patients with pJIA aged 4–17 years who failed ≥1 biologic or methotrexate received weight-tiered (< 75 kg: 10 mg/kg; 75–100 kg: 750 mg; > 100 kg: 1000 mg) intravenous abatacept at Weeks 0, 2, 4, and every 4 weeks thereafter. The study comprised a short-term period (16 weeks) and ongoing long-term period. Primary endpoint: Week 16 JIA-American College of Rheumatology criteria 30 (JIA-ACR30) response rate. Secondary endpoints/outcomes included Week 16 JIA-ACR50/70/90 response and inactive disease rates, Childhood Health Assessment Questionnaire-Disability Index (CHAQ-DI), pharmacokinetics, safety, and immunogenicity. Proportions of patients achieving Juvenile Arthritis Disease Activity Score in 27 joints using C-reactive protein (JADAS27-CRP) remission (score < 1) and minimal disease activity (MDA; score < 3.8), were among exploratory endpoints. Results: All 20 patients who received study medication completed the short-term period. During the long-term period, two patients discontinued due to insufficient efficacy or patient decision. Median age and disease duration at baseline were 10.5 and 0.75 years, respectively. Week 16 JIA-ACR30 response rate (primary endpoint) was 90.0% (18/20). JIA-ACR50/70/90 response and inactive disease rates at Week 16 were 75.0% (15/20), 70.0% (14/20), 35.0% (7/20), and 25.0% (5/20), respectively. At Week 52, JIA-ACR30/50/70/90 response and inactive disease rates were observed by 88.9% (16/18), 88.9% (16/18), 83.3% (15/18), 66.7% (12/18) and 44.4% (8/18), respectively. CHAQ-DI improved after Week 12. JADAS27-CRP remission and MDA were achieved by 15.0% (3/20) and 45.0% (9/20) of patients at Week 16, and by 50.0% (9/18) and 78.0% (14/18) of patients at Week 52, respectively. The mean abatacept pre-dose serum concentration was above the target therapeutic exposure (10 μg/ml) from Week 8 through Week 16. All adverse events were of mild/moderate intensity, except for one case of severe gastroenteritis. No deaths, malignancies, or autoimmune disorders were observed. No antidrug antibodies were detected through Week 16; one patient had a positive immunogenic response during the cumulative period. Conclusion: Intravenous abatacept was efficacious and well tolerated in Japanese patients with active pJIA.
論文 続きを見る |
||||||
| 4.
論文（リポジトリ） |
論文（リポジトリ）
|
Kawasaki, Yuri ; Miyake, Yoshihiro ; Tanaka, Keiko ; Furukawa, Shinya ; Arakawa, Masashi
概要:
Background: Epidemiological evidence on the relationship between smoking and secondhand smoke (SHS) exposure and depress
…
ive symptoms during pregnancy has been limited. The present cross-sectional study examined this issue in Japan. Methods: Between April 2007 and March 2008, 1757 pregnant women who lived in one of seven prefectures on Kyushu Island in southern Japan or in Okinawa Prefecture, an island chain in the southwest of Japan, participated in the Kyushu Okinawa Maternal and Child Health Study, a prebirth cohort study. In the present study, data on 1745 pregnant women were available for analysis. Information on smoking, SHS exposure, depressive symptoms, and potential confounding factors was obtained through a self-administered questionnaire. Depressive symptoms were defined as present when subjects had a Center for Epidemiologic Studies Depression Scale score of 16 or higher. Adjustment was made for age, gestation, region of residence, number of children, family structure, household income, education, job type, history of depression, and family history of depression. Results: The prevalence of depressive symptoms during pregnancy was 19.2%. Compared with having never smoked, both former and current smoking was independently associated with a higher prevalence of depressive symptoms during pregnancy: the adjusted odds ratios (ORs) were 1.39 (95% CI: 1.06–1.83) and 2.49 (95% CI: 1.36–4.45), respectively. Also, 3.0 to 7.9 and 8.0 or more pack-years of smoking were independently positively related to depressive symptoms during pregnancy: the adjusted ORs were 1.55 (95% CI: 1.08–2.22) and 1.97 (95% CI: 1.26–3.03), respectively (P for trend = 0.0005). Among the 1183 subjects who had never smoked, current SHS exposure at home was independently positively associated with depressive symptoms during pregnancy: the adjusted OR was 1.51 (95% CI: 1.003–2.30). Conclusions: Former and current smoking, 3.0 or more pack-years of smoking, and current SHS exposure at home may be positively associated with depressive symptoms during pregnancy.
論文 続きを見る |
||||||
| 5.
図書 |
図書
|
edited by Taro Kageyama and Wesley M. Jacobsen
|
||||||
| 6.
学位論文（リポジトリ） |
学位
|
山口, 智美 ; Yamaguchi, Satomi
概要:
学位論文
|
||||||
| 7.
論文（リポジトリ） |
論文（リポジトリ）
|
Takezawa, Yasuko ; Kato, Kazuto ; Oota, Hiroki ; Caulfield, Timothy ; Fujimoto, Akihiro ; Honda, Shunwa ; Kamatani, Naoyuki ; Kawamura, Shoji ; Kawashima, Kohei ; Kimura, Ryosuke ; Matsumae, Hiromi ; Saito, Ayako ; Savage, Patrick E. ; Seguchi, Noriko ; Shimizu, Keiko ; Terao, Satoshi ; Yamaguchi-Kabata, Yumi ; Yasukouchi, Akira ; Yoneda, Minoru ; Tokunaga, Katsushi
概要:
Background:A challenge in human genome research is how to describe the populations being studied. The use of improper an
…
d/or imprecise terms has the potential to both generate and reinforce prejudices and to diminish the clinical value of the research. The issue of population descriptors has not attracted enough academic attention outside North America and Europe. In January 2012, we held a two-day workshop, the first of its kind in Japan, to engage in interdisciplinary dialogue between scholars in the humanities, social sciences, medical sciences, and genetics to begin an ongoing discussion of the social and ethical issues associated with population descriptors.\nDiscussion:Through the interdisciplinary dialogue, we confirmed that the issue of race, ethnicity and genetic research has not been extensively discussed in certain Asian communities and other regions. We have found, for example, the continued use of the problematic term, “Mongoloid” or continental terms such as “European,” “African,” and “Asian,” as population descriptors in genetic studies. We, therefore, introduce guidelines for reporting human genetic studies aimed at scientists and researchers in these regions.\nConclusion:We need to anticipate the various potential social and ethical problems entailed in population descriptors. Scientists have a social responsibility to convey their research findings outside of their communities as accurately as possible, and to consider how the public may perceive and respond to the descriptors that appear in research papers and media articles.
論文 続きを見る |
||||||
| 8.
論文（リポジトリ） |
論文（リポジトリ）
|
儀保, ルシーラ悦子 ; Gibo, Lucila Etsuko
概要:
This paper analyses the Burajiru-Okinawa-Colonia-go (Brazilian-Okinawan community language), i.e., the language spoken i
…
n the Okinawan community of Brazil, from the Language Contact Theory point of view. In the Brazilian-Okinawan community, contact occurs between many regional dialects of Ryukyuan, the mainland Japanese dialects, the Japanese variation spoken by Okinawans, and naturally, with Brazilian- Portuguese. This linguistic contact causes (1) language change of the first-language (L1) due to lexical and grammatical borrowing, and (2) the birth of broken languages as a result of L1 influence in the process of second-language (L2) acquisition. First, in this paper, these two phenomena are examined through the analysis of the Ryukyuan, Japanese, and Portuguese spoken by the first and second generations. Second, this paper diagrams the language family tree of the Burajiru-Okinawa-Colonia-go. And finally, an attempt is made to classify it as pidgin, creole, interlanguage, or mixed language, by analyzing its linguistic and social characteristics.
紀要論文 続きを見る |
||||||
| 9.
論文（リポジトリ） |
論文（リポジトリ）
|
Miyake, Y ; Tanaka, K ; Arakawa, M
概要:
Background: Interleukin (IL) 4 plays a critical role in immune responses by acting as a growth factor for type 2 helper
…
T cells and inducing immunoglobulin (Ig) class switching to IgE. Epidemiological evidence of the relationship between single-nucleotide polymorphisms (SNPs) in IL4 and asthma is inconsistent. Objectives: We examined the association between the IL4 SNPs rs2243250, rs2070874, rs2227284, and rs2243290 and asthma in young adult Japanese women. Methods: The study population comprised 89 women who met the criteria of the European Community Respiratory Health Survey (ECRHS) for asthma. The control group comprised 1281 nonasthmatic women (ECRHS criteria) who had not been diagnosed with asthma by a physician. Adjustment was made for age, region of residence, presence of older siblings, smoking, and education. Results: Compared with the AA genotype of rs2243290, the AC genotype, but not the CC genotype, was signifi cantly associated with a reduced risk of asthma: the adjusted odds ratio for the AC genotype was 0.62 (95%CI, 0.39-0.996). No evident relationships were found between rs2243250, rs2070874, or rs2227284 and asthma. None of the haplotypes were signifi cantly associated with asthma. No signifi cant interactions were found between the 4 SNPs under study and smoking with respect to the risk of asthma. Conclusions: Ours is the fi rst study in a non-Western population to show that the IL4 SNP rs2243290 was signifi cantly associated with the risk of asthma. Smoking did not signifi cantly modify the gene-disease associations under study.
論文 続きを見る |
||||||
| 10.
論文（リポジトリ） |
論文（リポジトリ）
|
Miyake, Yoshihiro ; Tanaka, Keiko ; Arakawa, Masashi
概要:
Background: Epidemiological evidence for the association of socioeconomic status with prenatal depression has been incon
…
sistent. The current cross-sectional study examined the association between employment, job type, household income, and educational level and the prevalence of depressive symptoms during pregnancy. Methods: Subjects were 1741 Japanese women. Depressive symptoms were defined as present when subjects had a Center for Epidemiologic Studies Depression Scale score of 16 or higher. Adjustment was made for age, gestation, region of residence, family structure, personal and family history of depression, smoking, secondhand smoke exposure at home and at work, employment, household income, and education. Results: The prevalence of depressive symptoms during pregnancy was 19.3%. Compared with unemployment, employment, part-time employment, and full-time employment were significantly associated with a lower prevalence of depressive symptoms during pregnancy: the adjusted odds ratios (ORs) were 0.65 (95% confidence interval [CI]: 0.50 − 0.86), 0.66 (95% CI: 0.46 − 0.95), and 0.66 (95% CI: 0.48 − 0.90), respectively. Regarding the job type held, women with a professional or technical job and those with a clerical or related occupation had a significantly lower prevalence of depressive symptoms during pregnancy: the adjusted ORs were 0.67 (95% CI: 0.47 − 0.96) and 0.62 (95% CI: 0.43 − 0.90), respectively. Sales, service, production, and other occupations were not significantly related to the prevalence of depressive symptoms during pregnancy. There were no relationships between household income or education and the prevalence of depressive symptoms during pregnancy. Conclusions: Employment, whether full-time or part-time, and holding a professional or technical job or a clerical or related occupation may be inversely associated with the prevalence of depressive symptoms during pregnancy.
論文 続きを見る |
