1.

論文（リポジトリ）
論文（リポジトリ）
1. Whole-Genome Sequencing of a 900-Year-Old Human Skeleton Supports Two Past Migration Events from the Russian Far East to Northern Japan
Sato, Takehiro ; Adachi, Noboru ; Kimura, Ryosuke ; Hosomichi, Kazuyoshi ; Yoneda, Minoru ; Oota, Hiroki ; Tajima, Atsushi ; Toyoda, Atsushi ; Kanazawa-Kiriyama, Hideaki ; Matsumae, Hiromi ; Koganebuchi, Kae ; Shimizu, K Kentaro ; Shinoda, Ken-ichi ; Hanihara, Tsunehiko ; Weber, Andrzej ; Kato, Hirofumi ; Ishida, Hajime
出版情報: Genome Biology and Evolution.  13  2021-08-19.  Oxford University Press
URL: http://hdl.handle.net/20.500.12000/50052
概要: Recent studies on paleogenomics have reported some Paleolithic and Neolithic genomes that have provided new insights int … o the human population history in East and Northeast Asia. However, there remain some cases where more recent migration events need to be examined to elucidate the detailed formation process of local populations. Although the area around northern Japan is one of the regions archaeologically suggested to have been affected by migration waves after the Neolithic period, the genetic source of these migrations are still unclear. Thus, genomic data from such past migrant populations would be highly informative to clarify the detailed formation process of local populations in this region. Here, we report the genome sequence of a 900-year-old adult female (NAT002) belonging to the prehistoric Okhotsk people, who have been considered to be the past migrants to northern Japan after the Neolithic period. We found a close relationship between NAT002 and modern Lower Amur populations and past admixture events between the Amur, Jomon, and Kamchatka ancestries. The admixture dating suggested migration of Amur-related ancestry at approximately 1,600 BP, which is compatible with the archaeological evidence regarding the settlement of the Okhotsk people. Our results also imply migration of Kamchatka-related ancestry at approximately 2,000 BP. In addition, human leukocyte antigen (HLA) typing detected the HLA-B*40 allele, which is reported to increase the risk of arthritis, suggesting the genetic vulnerability of NAT002 to hyperostosis, which was observed around her chest clavicle.
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2.

論文（リポジトリ）
論文（リポジトリ）
2. Ancient Jomon genome sequence analysis sheds light on migration patterns of early East Asian populations
Gakuhari, Takashi ; Nakagome, Shigeki ; Rasmussen, Simon ; Allentoft, Morten E. ; Sato, Takehiro ; Korneliussen, Thorfinn ; Chuinneagain, Blanaid Ni ; Matsumae, Hiromi ; Koganebuchi, Kae ; Schmidt, Ryan ; Mizushima, Souichiro ; Kondo, Osamu ; Shigehara, Nobuo ; Yoneda, Minoru ; Kimura, Ryosuke ; Ishida, Hajime ; Masuyama, Tadayuki ; Yamada, Yasuhiro ; Tajima, Atsushi ; Shibata, Hiroki ; Toyoda, Atsushi ; Tsurumoto, Toshiyuki ; Wakebe, Tetsuaki ; Shitara, Hiromi ; Hanihara, Tsunehiko ; Willerslev, Eske ; Sikora, Martin ; Oota, Hiroki
出版情報: Communications Biology.  3  2020-08-25.  Springer Nature
URL: http://hdl.handle.net/20.500.12000/50006
概要: Anatomically modern humans reached East Asia more than 40,000 years ago. However, key questions still remain unanswered … with regard to the route(s) and the number of wave(s) in the dispersal into East Eurasia. Ancient genomes at the edge of the region may elucidate a more detailed picture of the peopling of East Eurasia. Here, we analyze the whole-genome sequence of a 2,500-year-old individual (IK002) from the main-island of Japan that is characterized with a typical Jomon culture. The phylogenetic analyses support multiple waves of migration, with IK002 forming a basal lineage to the East and Northeast Asian genomes examined, likely representing some of the earliest-wave migrants who went north from Southeast Asia to East Asia. Furthermore, IK002 shows strong genetic affinity with the indigenous Taiwan aborigines, which may support a coastal route of the Jomon-ancestry migration. This study highlights the power of ancient genomics to provide new insights into the complex history of human migration into East Eurasia.
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3.

論文（リポジトリ）
論文（リポジトリ）
3. Ancient Jomon genome sequence analysis sheds light on migration patterns of early East Asian populations
Gakuhari, Takashi ; Nakagome, Shigeki ; Rasmussen, Simon ; Allentoft, Morten E. ; Sato, Takehiro ; Korneliussen, Thorfinn ; Chuinneagain, Blanaid Ni ; Matsumae, Hiromi ; Koganebuchi, Kae ; Schmidt, Ryan ; Mizushima, Souichiro ; Kondo, Osamu ; Shigehara, Nobuo ; Yoneda, Minoru ; Kimura, Ryosuke ; Ishida, Hajime ; Masuyama, Tadayuki ; Yamada, Yasuhiro ; Tajima, Atsushi ; Shibata, Hiroki ; Toyoda, Atsushi ; Tsurumoto, Toshiyuki ; Wakebe, Tetsuaki ; Shitara, Hiromi ; Hanihara, Tsunehiko ; Willerslev, Eske ; Sikora, Martin ; Oota, Hiroki
出版情報: Communications Biology.  3  2020-08-25.  Springer Nature
URL: http://hdl.handle.net/20.500.12000/46972
概要: Anatomically modern humans reached East Asia more than 40,000 years ago. However, key questions still remain unanswered … with regard to the route(s) and the number of wave(s) in the dispersal into East Eurasia. Ancient genomes at the edge of the region may elucidate a more detailed picture of the peopling of East Eurasia. Here, we analyze the whole-genome sequence of a 2,500-year-old individual (IK002) from the main-island of Japan that is characterized with a typical Jomon culture. The phylogenetic analyses support multiple waves of migration, with IK002 forming a basal lineage to the East and Northeast Asian genomes examined, likely representing some of the earliest-wave migrants who went north from Southeast Asia to East Asia. Furthermore, IK002 shows strong genetic affinity with the indigenous Taiwan aborigines, which may support a coastal route of the Jomon-ancestry migration. This study highlights the power of ancient genomics to provide new insights into the complex history of human migration into East Eurasia.
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