1.

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論文(リポジトリ)
Tsuchida, Akiko ; Senda, Motohiro ; Ito, Akihiro ; Saito, Seiichi ; Kiso, Makoto ; Ando, Takayuki ; Harduin-Lepers, Anne ; Matsuda, Akio ; Furukawa, Keiko ; Furukawa, Koichi
出版情報: Scientific Reports.  10  2020-04-09.  Springer Nature
URL: http://hdl.handle.net/20.500.12000/47492
2.

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論文(リポジトリ)
Nakanishi, Shotaro ; Nishida, Sho ; Miyazato, Minoru ; Goya, Masato ; Saito, Seiichi
出版情報: Urology Case Reports.  29  2020-03.  Elsevier
URL: http://hdl.handle.net/20.500.12000/47488
概要: We present a 78-year-old male with renal cell carcinoma who developed myasthenia gravis complicated by myositis after nivolumab administration, which was verified by the presence of antibodies against the acetylcholine receptor. The initial symptom was posterior neck pain, and biochemical examination of blood showed elevated levels of hepatic enzymes and creatine phosphokinase. The level of antibody against the acetylcholine receptor increased 4.1-fold. His condition progressed rapidly resulting in respiratory failure 15 days after conservative therapy. 続きを見る
3.

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論文(リポジトリ)
Yonamine, Tomoko ; Kaname, Tadashi ; Chinen, Yasutsugu ; Tamashiro, Kouichi ; Kosuge, Noritake ; Saito, Seiichi
出版情報: Urology Case Reports.  30  2020-05.  Elsevier
URL: http://hdl.handle.net/20.500.12000/47486
概要: Hereditary leiomyomatosis and renal cell cancer is a rare, inherited disease caused by mutations in the fumarate hydratase gene. It is characterized by cutaneous leiomyomas, uterine leiomyomas, and/or renal cell cancer. We present the case of a 42-year-old woman with a heterozygous missense mutation (p.M195T) in the fumarate hydratase gene. Although the patient did not have cutaneous leiomyoma and she had no family history of hereditary leiomyomatosis and renal cell cancer, the presence of early onset symptomatic uterine leiomyoma and type 2 papillary renal cell cancer confirmed the diagnosis of hereditary leiomyomatosis and renal cell cancer. 続きを見る
4.

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論文(リポジトリ)
Matsumura, Eri ; Kosuge, Noritake ; Nakanishi, Shotaro ; Suda, Tetsuji ; Sugawa, Ai ; Fujimura, Tsutomu ; Miyagi, Ryota ; Yoshimi, Naoki ; Saito, Seiichi
出版情報: The Tohoku Journal of Experimental Medicine.  252  pp.225-244,  2020.  Tohoku University Medical Press
URL: http://hdl.handle.net/20.500.12000/47509
概要: Urothelial carcinoma of the bladder (UCB) is potentially life-threatening; therefore, we aimed to discover a novel urine biomarker for diagnosis and prognostication of UCB. This is a retrospective case-control study. Exploration of a new biomarker using urine from 20 UCB patients in the present study revealed that urinary level of lactoferrin (LF), a multifunctional glycoprotein released from neutrophils, was higher in 11 of 15 with invasive/high-grade UCB than 5 with non-invasive one, and 2 healthy adults. We therefore focused on LF and assessed the value of urine LF normalized by urine creatinine concentration (LF/Cr) using an enzyme-linked immunosorbent assay. Diagnostic performance of urine LF/Cr was examined using urine from 92 patients with primary (newly diagnosed) untreated UCB and 166 controls without UCB, including 62 patients with pyuria, and 104 subjects without pyuria consisting of 84 patients and 20 healthy adults. However, the diagnostic accuracies were accompanied by the risk of bias. In 92 primary UCB patients, both pyuria and tumor-infiltrating neutrophils (TINs) were independent predictors for urine LF/Cr. In contrast, TINs or urine LF/Cr were independent predictors for invasive histology, whereas pyuria was not. In terms of prognostication, urine LF/Cr and nodal metastasis were independent predictors of disease-specific survival in 22 patients with muscle-invasive bladder cancer, characterized by a high mortality rate, in the Cox proportional hazards model. In conclusion, urine LF/Cr linked to TINs was a predictor of both invasive histology and prognosis in UCB. Urine LF/Cr is a potential biomarker reflecting the degree of malignancy in UCB. 続きを見る
5.

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Nakamura, Yuichiro ; Miyata, Yasuyoshi ; Matsuo, Tomohiro ; Shida, Yohei ; Hakariya, Tomoaki ; Ohba, Kojiro ; Taima, Takenobu ; Ito, Akihiro ; Suda, Tetsuji ; Hakomori, Sen-itiroh ; Saito, Seiichi ; Sakai, Hideki
出版情報: Glycoconjugate Journal.  36  pp.409-418,  2019-06-26.  Springer Nature
URL: http://hdl.handle.net/20.500.12000/47508
概要: Stage-specific embryonic antigen-4 (SSEA-4), a specific marker for pluripotent stem cells, plays an important role in the malignant behavior of several cancers. Here, SSEA-4 expression was evaluated by immunohistochemistry using monoclonal antibody RM1 specific to SSEA-4 in 181 and 117 prostate cancer (PC) specimens obtained by biopsy and radical prostatectomy (RP), respectively. The relationships between SSEA-4 expression in cancer cells or the presence of SSEA-4-positive tumor-infiltrating immune cells (TICs) and clinicopathological parameters were analyzed. SSEA-4 expression in cancer cells was significantly associated with Gleason score, local progression, and lymph node and distant metastasis. In RP specimens, high SSEA-4 expression in cancer cells and the presence of SSEA-4-positive TICs were significant predictors of pT3, i.e., invasion and worse biochemical recurrence (BCR) after RP, respectively, in univariate analysis. In contrast, combination of high SSEA-4 expression in cancer cells and the presence of SSEA-4-positive TICs was an independent predictor for pT3 and BCR in multivariate analysis. Biologically this combination was also independently associated with suppression of apoptosis. Thus, the co-expression of SSEA-4 in cancer cells and TICs may have crucial roles in the malignant aggressiveness and prognosis of PC. Invasive potential and suppression of apoptosis may be linked to SSEA-4 expression. 続きを見る
6.

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論文(リポジトリ)
Tsuchida, Akio ; Senda, Motohiro ; Ito, Akihiro ; Saito, Seiichi ; Kiso, Makoto ; Ando, Takayuki ; Harduin-Lepers, Anne ; Matsuda, Akio ; Furukawa, Keiko ; Furukawa, Koichi
出版情報: Scientific Reports.  8  2018-05-04.  Springer Nature
URL: http://hdl.handle.net/20.500.12000/47490
概要: GalNAc-disialyl Lc4 (GalNAc-DSLc4) was reported as a novel antigen that associated with malignant features of renal cell cancers (RCCs). To clarify roles of GalNAc-DSLc4 in malignant properties of RCCs, we identified B4GalNAc-T2 as a responsible gene for the synthesis of GalNAc-DSLc4, and prepared stable transfectants of GalNAc-T2 cDNA using VMRC-RCW cells, resulting in the establishment of high expressants of GalNAc-DSLc4. They showed increased proliferation and invasion, and specific adhesion to laminin. In the transfectants, PI3K/Akt signals were highly activated by serum stimulation or adhesion to laminin. GalNAc-DSLc4 was co-localized in lipid rafts with integrin β1 and caveolin-1 in both immunoblotting of fractionated detergent extracts and immunocytostaining, particularly when stimulated with serum. Masking of GalNAc-DSLc4 with antibodies as well as PI3K inhibitor suppressed malignant properties of the transfectants. These results suggested that GalNAc-DSLc4 is involved in malignant properties of RCCs by forming a molecular complex with integrins in lipid rafts. 続きを見る
7.

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Maruyama, Nobuyuki ; Nakasone, Toshiyuki ; Arakaki, Osao ; Matsumoto, Hirofumi ; Maruyama, Tessho ; Matayoshi, Akira ; Goto, Takahiro ; Saito, Seiichi ; Yoshimi, Naoki ; Arasaki, Akira ; Nishihara, Kazuhide
出版情報: Oncology Letters.  16  pp.5249-5256,  2018-10.  Spandidos Publications
URL: http://hdl.handle.net/20.500.12000/45978
概要: Second primary cancer (SPC) is an important prognostic factor for patients with head and neck cancer (HNC); therefore, t he association between the prognosis and development of SPC has been well‑reported. The use of 2‑[18F]‑fluoro‑2‑deoxy‑D‑glucose‑positron emission tomography (FDG‑PET) is valuable to examine cancer stage, evaluate treatment responses and investigate suspected relapses or metastases. In the present study, the case of a male patient who was diagnosed with three primary cancer types, including well to moderately differentiated squamous cell carcinoma (SCC) of the mandible, axillary cutaneous poorly differentiated SCC and prostate adenocarcinoma, was described. Among these, mandible cancer was the first diagnosed when the patient was 70 years of age. Synchronous skin and prostate cancer (PRC) types then developed 3 years later. To the best of our knowledge, this is the first report of the aforementioned combination of cancer types. Postoperative FDG‑PET was not performed as no lesions of recurrence or metastases of mandible cancer were found. Three years later, the PRC was asymptomatic and was incidentally detected by FDG‑PET performed for a preoperative evaluation of skin cancer. It was indicated that FDG‑PET could be utilized in patients with HNC due to there being no accurate FDG‑PET protocol to detect SPC over a long‑term follow‑up. 続きを見る
8.

論文(リポジトリ)

論文(リポジトリ)
Nakanishi, Shotaro ; Miyazato, Minoru ; Miyagi, Ryota ; Saito, Seiichi
出版情報: Journal of Pediatric Surgery Case Reports.  31  pp.69-70,  2018-04.  Elsevier
URL: http://hdl.handle.net/20.500.12000/47493
概要: A male newborn was referred to our institute for postrenal acute renal failure with bilateral hydroureteronephrosis, electrolyte imbalance, and anuria. Voiding cystourethrography revealed no vesicoureteral reflux or posterior urethral valves. We performed bilateral percutaneous nephrostomy on the 9th post-natal day. The serum creatinine level improved to the normal range. Antegrade pyelography revealed bilateral uretero-vesical junction stenosis. Subsequently, we inserted bilateral double J urethral stents at 1 month. Bilateral ureteroneocystostomy without ureteral folding was performed at 6 months. The postoperative course was uneventful. This is the second case of postrenal acute renal failure with bilateral primary obstructive megaureters in a neonate. 続きを見る
9.

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論文(リポジトリ)
大城, 吉則 ; 安次嶺, 聡 ; 木村, 隆 ; 宮城, 亮太 ; 玉城, 由光 ; 仲西, 昌太郎 ; 松村, 英理 ; 大城, 琢磨 ; 宮里, 実 ; 呉屋, 真人 ; 斎藤, 誠一 ; Oshiro, Yoshinori ; Ashimine, Satoshi ; Kimura, Ryu ; Miyagi, Ryota ; Tamaki, Mitsuyoshi ; Nakanishi, Syotarou ; Matsumura, Eiri ; Oshiro, Takuma ; Goya, Masato ; Miyazato, Minoru ; Saito, Seiichi
出版情報: 移植.  51  pp.40-47,  2016-03-10.  一般社団法人 日本移植学会 — The Japan Society for Transplantation
URL: http://hdl.handle.net/20.500.12000/47494
概要: 【Objective】Good long-term kidney graft function and graft survival depend on multiple factors. This study aimed to asses s the impact of donor and recipient clinical factors on 20-year graft survival after kidney transplantation (KT). 【Material and Methods】From 1987-1994, twenty-five KTs (14 living and 11 deceased donors) were performed at Ryukyu University Hospital, and 24 of these cases were followed for more than 20 years after the KTs and reviewed. Ten patients had 20 years of graft survival, and 14 experienced graft failure for some reason within 20 years after KTs. Retrospective analyses were performed to elucidate the difference in donor and recipient factors among these patients. 【Results】The death censored graft survival rates at 5, 10, 15, and 20 years were 92.0%, 83.0%, 67.0%, and 67.0% in living-donor KTs and 73.0%, 62.0%, 62.0%, and 31.0% in deceased-donor KTs, respectively. The overall graft survival rates at 5, 10, 15, and 20 years were 85.0%, 77.0%, 62.0%, and 54.0% in living-donor KTs and 63.0%, 55.0%, 45.0%, and 27.0% in deceased-donor KTs, respectively. Comparison of clinical factors between the ≥ 20-year graft survivor group (10 cases) and <20-year graft survivor group (14 cases) revealed no differences in, for example, recipient age, duration of dialysis, donor age, donor type, number of human leukocyte antigen mismatches, and occurrence of acute rejections within 1 year of KTs. However, among 13 cases of living-donor KTs, the overall graft survivals after KTs from donors older than 50 years were worse than those after KTs from donors younger than 50 years. Also, the death-censored graft survivals after KTs from donors older than 60 years were worse than those after KTs from donors younger than 60 years. Moreover, graft survivals after KTs from maternal donors were worse than those after KTs from nonmaternal living donors, and there were no 20-year graft survivors after KTs from maternal donors. 【Conclusion】Our results suggest that the principal risk factors associated with <20-year graft survival after living-donor KTs are the presence of donors older than 50 or 60 years and a maternal donor. 続きを見る
10.

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Miyazato, Minoru ; Yamashiro, Satoshi ; Goya, Masato ; Inafuku, Hitoshi ; Ikehara, Akashi ; Oshiro, Yoshinori ; Saito, Seiichi ; Kuniyoshi, Yukio
出版情報: BMC Research Notes.  7  2014-10-01.  BioMed Central
URL: http://hdl.handle.net/20.500.12000/47331
概要: Background: Renal cell carcinoma with tumor thrombus extension into the inferior vena cava occurs in approximately 5% of cases. Despite such situations, an aggressive surgical approach is recommended. However, intraoperative prevention of pulmonary embolism by a fragmended tumor thrombus is necessary. To prevent pulmonary embolism, placement of a temporary suprarenal filter has been attempted, however, the precise placement of a temporary filter between the level of the hepatic vein and right atrium is not always easy because of its migration, tilting, and strut fracture. Here we report a method for early occlusion control of the intrapericardial inferior vena cava to prevent pulmonary embolism during nephrectomy in level II or III renal cell carcinoma tumor thrombus. Case presentation: Our first case was a 37-year-old Japanese man with left renal cell carcinoma extending into the inferior vena cava below the main hepatic vein (level II) and our second was a 75-year-old Japanese man with right renal cell carcinoma extending into the retrohepatic inferior vena cava at the main hepatic vein (level III). En block resection of the kidney and the tumor thrombus was performed with the aid of partial extracorporeal circulation; the postoperative course of both patients was uneventful. Conclusion: Control of intrapericardial inferior vena cava is a feasible method to prevent pulmonary embolism. 続きを見る