※一部利用できない機能があります
| 1.
論文（リポジトリ） |
論文（リポジトリ）
|
Yamauchi, Momoko ; Kinjo, Takeshi ; Parrott, Gretchen ; Miyagi, Kazuya ; Haranaga, Shusaku ; Nakayama, Yuko ; Chibana, Kenji ; Fujita, Kaori ; Nakamoto, Atsushi ; Higa, Futoshi ; Owan, Isoko ; Yonemoto, Koji ; Fujita, Jiro
概要:
Serum markers that differentiate between tuberculous and non-tuberculous pneumonia would be clinically useful. However,
…
few serum markers have been investigated for their association with either disease. In this study, serum levels of interferon gamma (IFN-γ), matrix metalloproteinases 1 and 9 (MMP-1 and MMP-9, respectively), and periostin were compared between 40 pulmonary tuberculosis (PTB) and 28 non-tuberculous pneumonia (non-PTB) patients. Diagnostic performance was assessed by analysis of receiver-operating characteristic (ROC) curves and classification trees. Serum IFN-γ and MMP-1 levels were significantly higher and serum MMP-9 levels significantly lower in PTB than in non- PTB patients (p < 0.001, p = 0.002, p < 0.001, respectively). No significant difference was observed in serum periostin levels between groups. ROC curve analysis could not determine the appropriate cut-off value with high sensitivity and specificity; therefore, a classification tree method was applied. This method identified patients with limited infiltration into three groups with statistical significance (p = 0.01), and those with MMP-1 levels < 0.01 ng/ mL and periostin levels ≥ 118.8 ng/mL included only non-PTB patients (95% confidence interval 0.0–41.0). Patients with extensive infiltration were also divided into three groups with statistical significance (p < 0.001), and those with MMP-9 levels < 3.009 ng/mL included only PTB patients (95% confidence interval 76.8–100.0). In conclusion, the novel classification tree developed using MMP-1, MMP-9, and periostin data distinguished PTB from non- PTB patients. Further studies are needed to validate our cut-off values and the overall clinical usefulness of these markers.
論文 続きを見る |
||||
| 2.
論文（リポジトリ） |
論文（リポジトリ）
|
兼島, 洋、 ; 下地, 勉 ; 大城, 元 ; 宮国, 孝彦 ; 大湾, 勤子 ; 嘉数, 朝一 ; 斎藤, 厚 ; Kaneshima, Hiroshi ; Shimoji, Tsutomu ; Oshiro, Hajime ; Miyaguni, Takahiko ; Owan, Isoko ; Kakazu, Tomokazu ; Saito, Atsushi
概要:
Sarcoidosis is a granulomatous disease with unknown etiology. It has already been reported that clinical findings of sar
…
coidosis differ among locations in the world. In Okinawa prefecture, we could not look for reports of collected sarcoidosis patients. We investigated 23 sarcoidosis cases from 1982 to 1993 in our faculty, who consisted of 8 males and 15 females with a mean age of 47 years. Fourteen (60.9%) of the total cases investigated were symptomatic with the percentage increasing with age. Recently symptomatic cases are on the increase. Lymphnodes biopsy was the most prefered diagnostic tool 13/14 (92.9%). In cases of sarcoidosis who there was liver involvement, alkaline phosphatase (ALP) levels were higher. These clinical findings were similar to other reports in the mainland. It is necessary that we study regional differences of morbidity and clinical findings in sarcoidosis.
論文 続きを見る |
