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Stage-specific embryonic antigen-4 is a histological marker reflecting the malignant behavior of prostate cancer
- 資料種別:
- 論文(リポジトリ)
- 責任表示:
- Nakamura, Yuichiro ; Miyata, Yasuyoshi ; Matsuo, Tomohiro ; Shida, Yohei ; Hakariya, Tomoaki ; Ohba, Kojiro ; Taima, Takenobu ; Ito, Akihiro ; Suda, Tetsuji ; Hakomori, Sen-itiroh ; Saito, Seiichi ; Sakai, Hideki
- 言語:
- 英語
- 出版情報:
- Springer Nature, 2019-06-26
- 著者名:
Nakamura, Yuichiro Miyata, Yasuyoshi Matsuo, Tomohiro Shida, Yohei Hakariya, Tomoaki Ohba, Kojiro Taima, Takenobu Ito, Akihiro Suda, Tetsuji Hakomori, Sen-itiroh Saito, Seiichi Sakai, Hideki - 掲載情報:
- Glycoconjugate Journal
- ISSN:
- 1573-4986
0282-0080 - 巻:
- 36
- 通号:
- 5
- 開始ページ:
- 409
- 終了ページ:
- 418
- バージョン:
- VoR
- 概要:
- Stage-specific embryonic antigen-4 (SSEA-4), a specific marker for pluripotent stem cells, plays an important role in the malignant behavior of several cancers. Here, SSEA-4 expression was evaluated by immunohistochemistry using monoclonal
…
antibody RM1 specific to SSEA-4 in 181 and 117 prostate cancer (PC) specimens obtained by biopsy and radical prostatectomy (RP), respectively. The relationships between SSEA-4 expression in cancer cells or the presence of SSEA-4-positive tumor-infiltrating immune cells (TICs) and clinicopathological parameters were analyzed. SSEA-4 expression in cancer cells was significantly associated with Gleason score, local progression, and lymph node and distant metastasis. In RP specimens, high SSEA-4 expression in cancer cells and the presence of SSEA-4-positive TICs were significant predictors of pT3, i.e., invasion and worse biochemical recurrence (BCR) after RP, respectively, in univariate analysis. In contrast, combination of high SSEA-4 expression in cancer cells and the presence of SSEA-4-positive TICs was an independent predictor for pT3 and BCR in multivariate analysis. Biologically this combination was also independently associated with suppression of apoptosis. Thus, the co-expression of SSEA-4 in cancer cells and TICs may have crucial roles in the malignant aggressiveness and prognosis of PC. Invasive potential and suppression of apoptosis may be linked to SSEA-4 expression.
論文 続きを見る - URL:
- http://hdl.handle.net/20.500.12000/47508