1.

論文(リポジトリ)

論文(リポジトリ)
Yonamine, Tomoko ; Kaname, Tadashi ; Chinen, Yasutsugu ; Tamashiro, Kouichi ; Kosuge, Noritake ; Saito, Seiichi
出版情報: Urology Case Reports.  30  2020-05.  Elsevier
URL: http://hdl.handle.net/20.500.12000/47486
概要: Hereditary leiomyomatosis and renal cell cancer is a rare, inherited disease caused by mutations in the fumarate hydrata se gene. It is characterized by cutaneous leiomyomas, uterine leiomyomas, and/or renal cell cancer. We present the case of a 42-year-old woman with a heterozygous missense mutation (p.M195T) in the fumarate hydratase gene. Although the patient did not have cutaneous leiomyoma and she had no family history of hereditary leiomyomatosis and renal cell cancer, the presence of early onset symptomatic uterine leiomyoma and type 2 papillary renal cell cancer confirmed the diagnosis of hereditary leiomyomatosis and renal cell cancer.
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2.

論文(リポジトリ)

論文(リポジトリ)
Matsumura, Eri ; Kosuge, Noritake ; Nakanishi, Shotaro ; Suda, Tetsuji ; Sugawa, Ai ; Fujimura, Tsutomu ; Miyagi, Ryota ; Yoshimi, Naoki ; Saito, Seiichi
出版情報: The Tohoku Journal of Experimental Medicine.  252  pp.225-244,  2020.  Tohoku University Medical Press
URL: http://hdl.handle.net/20.500.12000/47509
概要: Urothelial carcinoma of the bladder (UCB) is potentially life-threatening; therefore, we aimed to discover a novel urine biomarker for diagnosis and prognostication of UCB. This is a retrospective case-control study. Exploration of a new biomarker using urine from 20 UCB patients in the present study revealed that urinary level of lactoferrin (LF), a multifunctional glycoprotein released from neutrophils, was higher in 11 of 15 with invasive/high-grade UCB than 5 with non-invasive one, and 2 healthy adults. We therefore focused on LF and assessed the value of urine LF normalized by urine creatinine concentration (LF/Cr) using an enzyme-linked immunosorbent assay. Diagnostic performance of urine LF/Cr was examined using urine from 92 patients with primary (newly diagnosed) untreated UCB and 166 controls without UCB, including 62 patients with pyuria, and 104 subjects without pyuria consisting of 84 patients and 20 healthy adults. However, the diagnostic accuracies were accompanied by the risk of bias. In 92 primary UCB patients, both pyuria and tumor-infiltrating neutrophils (TINs) were independent predictors for urine LF/Cr. In contrast, TINs or urine LF/Cr were independent predictors for invasive histology, whereas pyuria was not. In terms of prognostication, urine LF/Cr and nodal metastasis were independent predictors of disease-specific survival in 22 patients with muscle-invasive bladder cancer, characterized by a high mortality rate, in the Cox proportional hazards model. In conclusion, urine LF/Cr linked to TINs was a predictor of both invasive histology and prognosis in UCB. Urine LF/Cr is a potential biomarker reflecting the degree of malignancy in UCB.
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3.

学位論文(リポジトリ)

学位
Kosuge, Noritake ; 小菅, 則豪
出版情報: Oncology Letters.  14  pp.2715-2722,  2017-06-23.  University of the Ryukyus — 琉球大学
URL: http://hdl.handle.net/20.500.12000/39245
概要: 学位論文
4.

論文(リポジトリ)

論文(リポジトリ)
Matsuzaki, Akiko ; Saio, Masanao ; Kosuge, Noritake ; Aoyama, Hajime ; Tamaki, Tomoko ; Matsumoto, Hirofumi ; Yoshimi, Naoki
出版情報: Case Reports in Obstetrics and Gynecology.  2017  2017-04-19.  Hindawi
URL: http://hdl.handle.net/20.500.12000/49788
概要: Primary villoglandular mucinous adenocarcinoma of the vulva is rare tumor. We report a case of 68-year-old woman who dev eloped this very uncommon malignant tumor. Immunohistochemical examination of this tumor revealed positive staining for Cytokeratin 20, Mucin 2, and CDX2, although Cytokeratin 7 and Mucin 6 were negative. This positive staining indicated the tumor enteric type characters. In order to exclude the possibility of the metastasis from another site, we thoroughly evaluated clinical data and extensively investigated the whole body. However, we could not detect any other tumors. The patient was treated by tumor resection. The patient remains free of disease 5 years after surgery.
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