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M. M. Emam Ahmed, ; M. Ashik Iqbal Khan ; Md. Shahjahan Kabir ; Fukuta, Yoshimichi ; Obara, Mitsuhiro
概要:
Genetic variations in the root traits of rice remain unexplored in relation to varietal groups and diverse ecosystems. Therefore, we evaluated 257 Bangladeshi accessions, which included landraces and improved varieties belonging to four
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ecotypes (Aus, Aman, Boro and Jhum), to understand genetic variations in the total root length (TRL), maximum root length and root number under different concentrations of ammonium and nitrate nitrogen in hydroponic culture. There were large variations in all traits across all nitrogen levels. Active elongation of individual roots of the landrace type across all nitrogen conditions suggested a higher potential for the uptake of nutrients by extending roots distribution in any nitrogen environment, while the active development of primary root primordia in the improved type in the presence of nitrate suggested a higher potential for the uptake of nitrate from the soil surface by extending roots distribution around soil surface. Cluster analysis classified the examined accessions into two groups according to their TRL: cluster I with a longer TRL and cluster II with a shorter TRL across all nitrogen conditions. Each of these groups was further divided into two subclusters: sub-cluster Ia, in which the longer TRL resulted from active development of primary root primordia, sub-cluster Ib, in which the longer TRL resulted from active elongation of individual roots, subcluster IIa, in which the shorter TRL resulted from severe reduction of the elongation of individual roots, and sub-cluster IIb, in which the shorter TRL resulted from a moderate reduction in the elongation of individual roots. Further investigation revealed a difference in the composition of these four sub-clusters among the four ecotypes, indicating that Aman was the most diverse ecotype, followed by Aus. The root traits of these promising accessions could be exploited in the future to understand genetic and physiological mechanism(s) of adaptation to diverse ecosystems.
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| 2.
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Nakamura, Hideta ; Miyagi, Kazuya ; Otsuki, Mariko ; Higure, Yuuri ; Nishiyama, Naoya ; Kinjo, Takeshi ; Nakamatsu, Masashi ; Haranaga, Shusaku ; Tateyama, Masao ; Fujita, Jiro
概要:
Treatment with tocilizumab (TCZ) to block interleukin-6 (IL-6) signalling is predicted to mitigate cytokine release synd
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rome (CRS) caused by coronavirus disease 2019 (COVID-19). However, the adverse effects of TCZ on patients with COVID-19 remain unclear. We herein report a patient with COVID-19 treated with TCZ who developed acute hypertriglyceridaemia. Despite favipiravir treatment, acute respiratory distress syndrome developed in a 45-year-old patient with COVID-19; thus, TCZ was initiated. The triglyceride levels greatly increased after TCZ administration. Physicians should consider the negative impact of TCZ on the lipid profile in patients with COVID-19, although COVID-19-induced CRS itself may be an aggravating factor.
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Saleh, Ayat Ali ; Senjyu, Tomonobu ; Alkhalaf, Salem ; Alotaibi, Majed A. ; Hemeida, Ashraf M.
概要:
This work introduces multi-objective water cycle algorithm (MOWCA) to find the accurate location and size of distributed
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energy resource (DERs) considering different load models for two seasons (winter, and summer). The impact of uncertainties produced from load and renewable energy resource (RES) such as wind turbine (WT) and photovoltaic (PV) on the performance of the radial distribution system (RDS) are covered as this is closer to the real operation condition. The point estimate method (PEM) is applied for modeling the RES uncertainties. An optimization technique is implemented to find the multi-objective optimal allocation of RESs in RDSs considering uncertainty effect. The main objectives of the work are to maximize the technical, economic and environmental benefits by minimizing different objective functions such as the dissipated power, the voltage deviation, DG cost and total emissions. The proposed multi-objective model is solved by using multi-objective water cycle algorithm (MOWCA), considering the Pareto criterion with nonlinear sorting based on fuzzy mechanism. The proposed algorithm is carried out on different IEEE power systems with various cases.
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Miyagi, Yoshihiro ; Kinjo, Tatsuya ; Yoshizumi, Tomoharu ; Harada, Noboru ; Arakaki, Shingo ; Kinjo, Tetsu ; Hokama, Akira ; Takatsuki, Mitsuhisa
概要:
Background: Primary sclerosing cholangitis (PSC) is a well-known complication of ulcerative colitis (UC), but it is rare
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to encounter patients requiring both living donor liver transplantation (LDLT) and proctocolectomy. We report a case of elective two-stage surgery involving proctocolectomy performed after LDLT for a patient with early colon cancer concurrent with PSC-related UC. To our knowledge, this is the first report of concurrent cancer successfully treated with both LDLT and proctocolectomy. Case presentation: A 32-year-old Japanese man with colon cancer associated with UC underwent restorative proctocolectomy at 3 months after living donor liver transplantation (LDLT) for PSC. He was diagnosed with PSC and UC when he was a teenager. Conservative therapy was initiated to treat both PSC and UC. He had experienced recurrent cholangitis for years; therefore, a biliary stent was placed endoscopically. However, his liver function progressively deteriorated. Colonoscopic surveillance revealed early colon cancer; hence, surgical treatment was considered. PSC progressed to cirrhosis and portal hypertension; hence, LDLT was performed before restorative proctocolectomy. Three months after LDLT, we performed restorative proctocolectomy with ileal pouch–anal anastomosis. The postoperative course was uneventful. The patient was well, with good liver and bowel functions and without tumor recurrence, more than 1 year after proctocolectomy. Conclusions: With strict patient selection and careful patient management and follow-up, elective proctocolectomy may be performed safely and effectively after LDLT for concurrent early colon cancer with PSC-related UC. There are no previous reports of the use of both LDLT and proctocolectomy for the successful treatment of PSC-related UC and concurrent cancer.
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Ihara, Kensuke ; Sasano, Tetsuo ; Hiraoka, Yuichi ; Togo-Ohno, Marina ; Soejima, Yurie ; Sawabe, Motoji ; Tsuchiya, Megumi ; Ogawa, Hidesato ; Furukawa, Tetsushi ; Kuroyanagi, Hidehito
概要:
Dilated cardiomyopathy (DCM) is a fatal heart disease characterized by left ventricular dilatation and cardiac dysfuncti
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on. Recent genetic studies on DCM have identified causative mutations in over 60 genes, including RBM20, which encodes a regulator of heart-specific splicing. DCM patients with RBM20 mutations have been reported to present with more severe cardiac phenotypes, including impaired cardiac function, atrial fibrillation (AF), and ventricular arrhythmias leading to sudden cardiac death, compared to those with mutations in the other genes. An RSRSP stretch of RBM20, a hotspot of missense mutations found in patients with idiopathic DCM, functions as a crucial part of its nuclear localization signals. However, the relationship between mutations in the RSRSP stretch and cardiac phenotypes has never been assessed in an animal model. Here, we show that Rbm20 mutant mice harboring a missense mutation S637A in the RSRSP stretch, mimicking that in a DCM patient, demonstrated severe cardiac dysfunction and spontaneous AF and ventricular arrhythmias mimicking the clinical state in patients. In contrast, Rbm20 mutant mice with frame-shifting deletion demonstrated less severe phenotypes, although loss of RBM20-dependent alternative splicing was indistinguishable. RBM20^
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Nakamura, Hideta ; Tateyama, Masao ; Tasato, Daisuke ; Haranaga, Shusaku ; Higa, Futoshi ; Matsuzaki, Akiko ; Yoshimi, Naoki ; Fujita, Jiro
概要:
Asymptomatic pulmonary sarcoidosis can develop after starting antiretroviral therapy. The decision on whether to treat sarcoidosis with corticosteroids should be based on the disease severity.
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Akamine, Kozue ; Mekaru, Keiko ; Gibo, Keiya ; Nagata, Chinatsu ; Nakamura, Rie ; Oishi, Sugiko ; Miyagi, Maho ; Heshiki, Chiaki ; Aoki, Yoichi
概要:
Purpose: To investigate impact of the one‐carbon metabolism (OCM) on oocyte maturity and embryo development.\nMethods: T
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his prospective study analyzed 18 women who agreed to participate. We measured the OCM biomarkers’ concentrations including Vitamin B12 (VB12), folic acid (FA), and homocysteine (Hcy) in serum and follicular fluid (FF), and assessed their correlation. We also evaluated the influence of such OCM biomarker concentrations in mono‐FF on oocyte maturation, fertilization, embryo quality, and consequent pregnancy after embryo transfers.\nResults: All biomarkers showed a high concentration variability in different follicles of each woman, but their mean levels correlated with the serum levels. Among the 106 collected oocytes, 92 were mature, 59 were fertilized, and 16 yielded good‐quality embryos. We performed 26 single embryo transfers, and 7 patients achieved clinical pregnancies. VB12 concentration (FF) was significantly lower in fertilized than unfertilized oocytes by univariate analysis. In multivariate logistic analysis, a significant correlation was found between FA concentration (FF) <14.25 ng/mL and good‐quality embryos and between Hcy concentration (FF) <4.9 nmol/mL and clinical pregnancy.\nConclusion: OCM in FF may affect fertilization, embryo quality, and clinical pregnancy.
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Nakagawa, Tessui ; Uesato, Hiroki ; Burrell, Anthony K. ; Ichikawa, Takayuki ; Miyaoka, Hiroki ; Davis, Benjamin L. ; Kojima, Yoshitsugu
概要:
“One-pot regeneration”, which is simple regneneration method of ammonia borane (AB) using hydrazine and liquid ammonia,
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enables conversion of AB from hexagonal boron nitride (h-BN) after milling hydrogenation. Solution ^<11>B-NMR revealed the presence of AB after NH_3/N_2H_4 treatment of milled h-BN (BNH_x) although the yield of AB was less than 5%. The conversion mechanism was clarified as B-H bonds on the h-BN surface created by ball-milling under hydrogen pressure have an ability to form AB, which was confirmed by Thermogravimetry-Residual Gas Analysis (TG-RGA) and Infrared (IR) analysis. The reaction routes are also the same as regeneration route of polyborazylene because intermediates of AB such as (B(NH_2)_3 and hydrazine borane were found by solution ^<11>B-NMR after soaking BNH_x in liquid NH_3 and hydrazine, respectively. Because of the fact that all reactions proceed on the h-BN surface and no reaction proceeds when neat h-BN is treated, breaking of B_3N_3 ring structure and then creation of B-H bond is the key issue to increase conversion yield of AB.
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| 9.
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大島, 千幸 ; 林, 幸希 ; 寺井, 純汰 ; 工藤, 翔里 ; Oshima, Kazuyuki ; Hayashi, Koki ; Terai, Junta ; Kudo, Shori
概要:
This study records six Mantodea species from several islands in the Miyako Islands, including first records from some is
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lands. Of the six Mantodea species, four species, i.e. Statilia nemoralis (Saussure, 1870), Tenodera fasciata (Olivier, 1792), T. angustipennis Saussure, 1869 and Hierodula patellifera (Audinet-Serville, 1839), are newly recorded from some adjacent islands of Miyako-jima Island, and two species, i.e. Mantis religiosa (Linnaeus, 1758) and Amantis nawai (Shiraki, 1908), were collected from previously recorded islands in the Miyako Is. Mantis religiosa and T. fasciata were primarily observed in open grasslands, and in contrast, T. angustipennis was mainly found around forest edges on Tarama-jima I. Few nymphs and an ootheca of S. nemoralis were found in grasslands on Ikema-jima I. and Kurima-jima I. Hierodula patellifera was the most abundant among mantis species during these surveys; a number of adults and a few nymphs of this species were observed in our expedition. For Amantis nawai, specimens of only the adult stage were observed, on the dried leaf litter of the forest floor on Miyako-jima I. In addition, three Mantodea species, M. religiosa, T. angustipennis and H. patellifera, were collected from UV-LED light trap set as a counterplan against Anomala albopilosa (Hope, 1839) (Coleoptera: Scarabaeidae) on Tarama-jima I.
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Yamasako, Junsuke ; Kuroda, Keita ; 山迫, 淳介 ; 黒田, 圭太
概要:
Cophinopoda chinensis (Fabricius, 1794) is newly recorded from the Miyako Islands, the Ryukyus, Japan, with DNA barcode
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data.
東南アジアに広く分布するアオメアブCophinopoda chinensisを池間島,伊良部島,宮古島,来間島にて採集された標本に基づいて宮古諸島より初めて記録し,来間島の１個体より得たDNAバーコード配列の登録情報を記した. 論文 続きを見る |
