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1.
図書 |
Jane Bottomley
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2.
図書 |
Michael Dine
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3.
論文(リポジトリ) |
Takeshima, Masahiro ; Otsubo, Tempei ; Funada, Daisuke ; Murakami, Maki ; Usami, Takashi ; Maeda, Yoshihiro ; Yamamoto, Taisuke ; Matsumoto, Toshihiko ; Shimane, Takuya ; Aoki, Yumi ; Otowa, Takeshi ; Tani, Masayuki ; Yamanaka, Gaku ; Sakai, Yojiro ; Murao, Tomohiko ; Inada, Ken ; Yamada, Hiroki ; Kikuchi, Toshiaki ; Sasaki, Tsukasa ; Watanabe, Norio ; Mishima, Kazuo ; Takaesu, Yoshikazu
概要:
Long-term use of benzodiazepines (BZD) is not recommended for the treatment of anxiety disorders. Cognitive behavioral therapy (CBT) is an effective treatment option for discontinuation of BZD in patients with anxiety disorders. This
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systematic review and meta-analysis sought to clarify whether CBT is effective for discontinuing BZD anxiolytics in patients with anxiety disorders. This study was preregistered with PROSPERO (registration number: CRD42019125263). A literature search of major electronic databases was conducted in December 2018. Three randomized controlled trials were included in this review, and meta-analyses were performed. The proportion of discontinuing BZD anxiolytics was significantly higher in the CBT plus gradual tapering group than in the gradual tapering alone group, both in the short term (3 months after allocation; number needed to treat: 3.2, 95% confidence interval [CI]: 2.1 to 7.1; risk ratio: 1.96, 95%CI: 1.29 to 2.98, P = 0.002, three studies) and long term (6 to 12 months after allocation; number needed to treat: 2.8, 95%CI: 1.9 to 5.3; risk ratio: 2.16, 95%CI: 1.41 to 3.32, P = 0.0004, three studies). CBT may be effective for discontinuing BZD anxiolytics, both in the short term and in the long term after the allocation. Further studies with larger sample sizes are necessary to draw definitive conclusions regarding the efficacy and safety of CBT for discontinuing BZD anxiolytics in patients with anxiety disorders.
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4.
論文(リポジトリ) |
Noguchi, Yuko ; Nonaka, Daisuke ; Kounnavong, Sengchanh ; Kobayashi, Jun
概要:
Diarrhea is a leading cause of death among children under five (U5) in Lao People’s Democratic Republic (PDR). This stud
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y assessed the association between the presence of household hand-washing facilities with water and soap and diarrhea episodes among children U5 in Lao PDR. Data from the Lao Social Indicator Survey II were used. The outcome variable was diarrhea episodes in the two weeks preceding the survey. The main predictor variable was the presence of household hand-washing facilities with or without water and/or soap. Mixed-effect logistic regression analysis was used to assess the association, controlling for clustering, and other predictor variables. Of the 8640 households surveyed with 11,404 children, 49.1% possessed hand-washing facilities with both water and soap and 34.7% possessed hand-washing facilities with water alone. Children whose households possessed hand-washing facilities with water alone were significantly more likely to have a diarrhea episode compared to children whose households possessed hand-washing facilities with both water and soap (8.1% vs. 5.9%; odds ratio, 1.49; 95% confidence interval, 1.22–1.81). The association remained significant even after adjusting for other predictors. The absence of soap in hand-washing facilities was associated with higher odds of having a diarrhea episode among children U5 in Lao PDR.
論文 続きを見る |
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5.
論文(リポジトリ) |
Nakamura, Hideta ; Ouchi, Gen ; Miyagi, Kazuya ; Higure, Yuuri ; Otsuki, Mariko ; Nishiyama, Naoya ; Kinjo, Takeshi ; Nakamatsu, Masashi ; Tateyama, Masao ; Kukita, Ichiro ; Fujita, Jiro
概要:
Anticoagulation plays a major role in reducing the risk of systematic thrombosis in patients with severe COVID-19. Serious hemorrhagic complications, such as intracranial hemorrhage, have also been recognized. However, intra-abdominal
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hemorrhage is under-recognized because of its rare occurrence, despite high mortality. Here, we discuss two cases of spontaneous iliopsoas hematoma (IPH) likely caused by anticoagulants during the clinical course of COVID-19. We also explored published case reports to identify clinical characteristics of IPH in COVID-19 patients. The use of anticoagulants may increase the risk of lethal IPH among COVID-19 patients becsuse of scarce data on optimal dosage and adequate monitoring of anticoagulant effects. Rapid diagnosis and timely intervention are crucial to ensure good patient outcomes.
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6.
図書 |
edited by Gino Cattani ... [et al.]
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7.
図書 |
Matt Carter
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8.
図書 |
Frederick M. Azar, James H. Beaty
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9.
図書 |
Frederick M. Azar, James H. Beaty
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10.
図書 |
Frederick M. Azar, James H. Beaty
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