Stage-specific embryonic antigen-4 is a histological marker reflecting the malignant behavior of prostate cancer

資料種別:
論文(リポジトリ)
責任表示:
Nakamura, Yuichiro ; Miyata, Yasuyoshi ; Matsuo, Tomohiro ; Shida, Yohei ; Hakariya, Tomoaki ; Ohba, Kojiro ; Taima, Takenobu ; Ito, Akihiro ; Suda, Tetsuji ; Hakomori, Sen-itiroh ; Saito, Seiichi ; Sakai, Hideki
言語:
英語
出版情報:
Springer Nature, 2019-06-26
著者名:
Nakamura, Yuichiro
Miyata, Yasuyoshi
Matsuo, Tomohiro
Shida, Yohei
Hakariya, Tomoaki
Ohba, Kojiro
Taima, Takenobu
Ito, Akihiro
Suda, Tetsuji
Hakomori, Sen-itiroh
Saito, Seiichi
Sakai, Hideki
続きを見る
掲載情報:
Glycoconjugate Journal
ISSN:
1573-4986  CiNii Articles  Webcat Plus  JAIRO
0282-0080  CiNii Articles  Webcat Plus  JAIRO
巻:
36
通号:
5
開始ページ:
409
終了ページ:
418
バージョン:
publisher
概要:
Stage-specific embryonic antigen-4 (SSEA-4), a specific marker for pluripotent stem cells, plays an important role in the malignant behavior of several cancers. Here, SSEA-4 expression was evaluated by immunohistochemistry using monoclonal antibody RM1 specific to SSEA-4 in 181 and 117 prostate cancer (PC) specimens obtained by biopsy and radical prostatectomy (RP), respectively. The relationships between SSEA-4 expression in cancer cells or the presence of SSEA-4-positive tumor-infiltrating immune cells (TICs) and clinicopathological parameters were analyzed. SSEA-4 expression in cancer cells was significantly associated with Gleason score, local progression, and lymph node and distant metastasis. In RP specimens, high SSEA-4 expression in cancer cells and the presence of SSEA-4-positive TICs were significant predictors of pT3, i.e., invasion and worse biochemical recurrence (BCR) after RP, respectively, in univariate analysis. In contrast, combination of high SSEA-4 expression in cancer cells and the presence of SSEA-4-positive TICs was an independent predictor for pT3 and BCR in multivariate analysis. Biologically this combination was also independently associated with suppression of apoptosis. Thus, the co-expression of SSEA-4 in cancer cells and TICs may have crucial roles in the malignant aggressiveness and prognosis of PC. Invasive potential and suppression of apoptosis may be linked to SSEA-4 expression. 続きを見る
URL:
http://hdl.handle.net/20.500.12000/47508
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